# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA968033 | Functional | Agonist activity at GPR119 expressed in HEK293 cells assessed as cAMP level by flash plate assay | 9 | ALA1139413 | cell-based format | Scientific Literature | ||
2. | ALA968034 | Functional | Inverse agonist activity at GPR119 expressed in HEK293 cells assessed as cAMP level by flash plate assay | 5 | ALA1139413 | cell-based format | Scientific Literature | ||
3. | ALA968035 | Functional | Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation | 18 | ALA1139413 | assay format | Scientific Literature | ||
4. | ALA1686739 | Functional | Agonist activity against human GPR119 receptor expressed in HEK293 cells assessed as beta-lactamase production by cAMP response element assay | Homo sapiens | 16 | ALA1681688 | cell-based format | Scientific Literature | |
5. | ALA1686740 | Functional | Intrinsic activity against human GPR119 receptor expressed in HEK293 cells assessed as beta-lactamase production by cAMP response element assay | Homo sapiens | 16 | ALA1681688 | cell-based format | Scientific Literature | |
6. | ALA1107065 | Functional | Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-transfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay | Homo sapiens | 28 | ALA1156968 | cell-based format | Scientific Literature | |
7. | ALA1107066 | Functional | Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-transfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay relative to N-(4-(1H-1,2,4-triazol-1-yl)phenyl)-5-nitro-6-(4-(pyridin-2-ylthio)piperidin-1-yl)pyrimidin-4-amine maximal response | Homo sapiens | 28 | ALA1156968 | cell-based format | Scientific Literature | |
8. | ALA1107067 | Functional | Agonist activity at human GPR119 receptor by cAMP mobilization assay | Homo sapiens | 1 | ALA1156968 | assay format | Scientific Literature | |
9. | ALA1769445 | Functional | Agonist activity at GPR119 in human HEK293 cells assessed as increase in cAMP level after 16 hrs by beta-lactamase reporter gene assay | Homo sapiens | 5 | ALA1764954 | cell-based format | Scientific Literature | |
10. | ALA1769546 | Functional | Intrinsic activity at GPR119 in human HEK293 cells assessed as increase in cAMP level after 16 hrs by beta-lactamase reporter gene assay relative to WO2005121121 | Homo sapiens | 5 | ALA1764954 | cell-based format | Scientific Literature | |
11. | ALA1769548 | Functional | Antagonist activity at GPR119 in human HEK293 cells assessed as cAMP level after 16 hrs by beta-lactamase reporter gene assay | Homo sapiens | 1 | ALA1764954 | cell-based format | Scientific Literature | |
12. | ALA1769549 | Binding | Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate from GPR119 in human HEK293 cells by liquid scintillation counting | Homo sapiens | 5 | ALA1764954 | cell-based format | Scientific Literature | |
13. | ALA1772424 | Functional | Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assay | Homo sapiens | 40 | ALA1770133 | cell-based format | Scientific Literature | |
14. | ALA1772426 | Functional | Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation at 10 uM after 60 mins by HTRF assay | Homo sapiens | 3 | ALA1770133 | cell-based format | Scientific Literature | |
15. | ALA1775788 | Functional | Agonist activity at human GPR119 by melanophore assay | Homo sapiens | 32 | ALA1773020 | assay format | Scientific Literature | |
16. | ALA1775789 | Functional | Agonist activity at human GPR119 by melanophore assay relative to AR231453 | Homo sapiens | 26 | ALA1773020 | assay format | Scientific Literature | |
17. | ALA1775792 | Functional | Agonist activity at human GPR119 expressed in human HEK293 cells assessed as increase in adenylate cyclase activation | Homo sapiens | 1 | ALA1773020 | cell-based format | Scientific Literature | |
18. | ALA1781103 | Functional | Agonist activity at human GPR119 expressed in HEK293 cells assessed as stimulation of cMAP level by cell-based cAMP assay | Homo sapiens | 41 | ALA1777763 | cell-based format | Scientific Literature | |
19. | ALA1781104 | Functional | Agonist activity at human GPR119 expressed in HEK293 cells assessed as maximal stimulation of cMAP level by cell-based cAMP assay relative to 21 | Homo sapiens | 33 | ALA1777763 | cell-based format | Scientific Literature | |
20. | ALA3387010 | Functional | Agonist activity at human GPR119 overexpressed in CHO cells assessed as increase in cellular cAMP production by HTRF method | Homo sapiens | 33 | ALA3351405 | cell-based format | Scientific Literature |