# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1050553 | Binding | Displacement of [3H]PGH2 from human recombinant PGES1 expressed in CHOK1 cells | Homo sapiens | 37 | ALA1156058 | cell-based format | Scientific Literature | |
2. | ALA1050554 | Binding | Inhibition of mPGES1 in IL-1-beta-stimulated human A549 cells assessed as blockade of PGH2 to PGE2 conversion in presence of 50% fetal bovine serum | Homo sapiens | 27 | ALA1156058 | cell-based format | Scientific Literature | |
3. | ALA1036472 | Binding | Inhibition of mPGES1 in IL1-beta treated human A549 cell microsomal membrane assessed as blockade of PGH2 to PGE2 conversion after 1 min | Homo sapiens | 1 | ALA1158497 | microsome format | Scientific Literature | |
4. | ALA1036473 | Binding | Selectivity of inhibition of mPGES1 in IL1-beta treated human A549 cell microsomal membrane to inhibition of mPGES1 in IL1-beta treated human A549 cells | Homo sapiens | 1 | ALA1158497 | cell-based format | Scientific Literature | |
5. | ALA1036474 | Binding | Inhibition of mPGES1 in IL1-beta treated human A549 cell microsomal membrane assessed as residual enzyme activity at 10 uM after 1 min by measuring PGE2 level using RP-HPLC method relative to control | Homo sapiens | 15 | ALA1158497 | microsome format | Scientific Literature | |
6. | ALA1036475 | Binding | Inhibition of mPGES1 in IL1-beta treated human A549 cell microsomal membrane assessed as residual enzyme activity at 100 nM after 1 min by measuring PGE2 level using RP-HPLC method relative to control | Homo sapiens | 1 | ALA1158497 | microsome format | Scientific Literature | |
7. | ALA1036476 | Binding | Inhibition of mPGES1 in IL1-beta treated human A549 cell microsomal membrane assessed as residual enzyme activity after 1 min by measuring PGE2 level using RP-HPLC method | Homo sapiens | 16 | ALA1158497 | microsome format | Scientific Literature | |
8. | ALA1036480 | Binding | Ratio of IC50 for drug to IC50 for licofelone against human mPGES1 | Homo sapiens | 1 | ALA1158497 | single protein format | Scientific Literature | |
9. | ALA1012767 | Binding | Inhibition of mPGES1 in human A549 cells assessed as inhibition of IL-1-beta-induced PGE2 formation at 10 uM by cell-intact assay | Homo sapiens | 1 | ALA1151733 | cell-based format | Scientific Literature | |
10. | ALA1012768 | Binding | Inhibition of mPGES1 in human A549 cells assessed as inhibition of IL-1-beta-induced PGE2 formation at 5 uM by cell-intact assay | Homo sapiens | 1 | ALA1151733 | cell-based format | Scientific Literature | |
11. | ALA1012769 | Binding | Inhibition of mPGES1 in human A549 cells assessed as inhibition of IL-1-beta-induced PGE2 formation by cell-intact assay | Homo sapiens | 3 | ALA1151733 | cell-based format | Scientific Literature | |
12. | ALA1012772 | Binding | Inhibition of mPGES1 in human A549 cells assessed as inhibition of IL-1-beta-induced PGE2 formation at 33 uM by cell-intact assay | Homo sapiens | 1 | ALA1151733 | cell-based format | Scientific Literature | |
13. | ALA1012773 | Binding | Inhibition of mPGES1 | 1 | ALA1151733 | single protein format | Scientific Literature | ||
14. | ALA1014417 | Binding | Inhibition of PGES1 in human A549 cell microsome assessed as PGE2 formation at 10 uM by cell-free assay relative to control | Homo sapiens | 29 | ALA1151733 | cell-based format | Scientific Literature | |
15. | ALA1014420 | Binding | Inhibition of PGES1 in human A549 cell microsome assessed as PGE2 formation by cell-free assay | Homo sapiens | 11 | ALA1151733 | cell-based format | Scientific Literature | |
16. | ALA1686709 | Binding | Inhibition of mPGES-1 expressed in LPS-stimulated human A549 cells mitochondrial fraction assessed as conversion of PGH2 to PGE2 | 15 | ALA1681685 | cell-based format | Scientific Literature | ||
17. | ALA1686710 | Binding | Inhibition of mPGES-1 expressed in LPS-stimulated human A549 cells mitochondrial fraction assessed as remaining activity at 10 uM | 10 | ALA1681685 | cell-based format | Scientific Literature | ||
18. | ALA1686169 | Binding | Inhibition of human mPGES1 at 10 uM | Homo sapiens | 1 | ALA1681669 | single protein format | Scientific Literature | |
19. | ALA1686170 | Binding | Inhibition of mPGES1 | 40 | ALA1681669 | single protein format | Scientific Literature | ||
20. | ALA1686171 | Binding | Inhibition of mPGES1 in IL1-beta treated human A549 cell microsome assessed as inhibition of PGE2 production after 1 min in presence of 50% FBS | Homo sapiens | 36 | ALA1681669 | cell-based format | Scientific Literature |