# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1121233 | Binding | Inhibition of CRM1-mediated nuclear export of Rio2 in human HeLa cells at 2 uM | Homo sapiens | 4 | ALA1158550 | cell-based format | Scientific Literature | |
2. | ALA1110148 | Binding | Inhibition of CRM1-mediated nuclear export of Rio2 in human HeLa cells at 1 uM | Homo sapiens | 1 | ALA1158550 | cell-based format | Scientific Literature | |
3. | ALA1120676 | Binding | Inhibition of CRM1-mediated hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nuclear localization at 5 uM after 12 hrs by indirect fluorescent antibody technique | Homo sapiens | 1 | ALA1158624 | cell-based format | Scientific Literature | |
4. | ALA1120677 | Binding | Inhibition of CRM1-mediated hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization after 12 hrs by indirect fluorescent antibody technique | Homo sapiens | 5 | ALA1158624 | cell-based format | Scientific Literature | |
5. | ALA1120678 | Binding | Inhibition of CRM1-mediated hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization at 25 uM after 12 hrs by indirect fluorescent antibody technique | Homo sapiens | 1 | ALA1158624 | cell-based format | Scientific Literature | |
6. | ALA4361830 | Binding | Inhibition of CRM1 in human HepG2 cells assessed as accumulation of RIOK2 in nucleus at 1 and 10 uM measured after 24 hrs by DAPI staining based confocal microscopy analysis | Homo sapiens | 1 | ALA4359853 | cell-based format | Scientific Literature | |
7. | ALA4361832 | Binding | Inhibition of CRM1 in human HepG2 cells assessed as accumulation of RIOK2 in nucleus at 0.1 to 10 uM measured after 6 hrs by DAPI staining based confocal microscopy analysis | Homo sapiens | 1 | ALA4359853 | cell-based format | Scientific Literature | |
8. | ALA4361833 | Binding | Inhibition of CRM1 in human HuH7 cells assessed as accumulation of RIOK2 in nucleus at 1 and 10 uM measured after 24 hrs by DAPI staining based confocal microscopy analysis | Homo sapiens | 2 | ALA4359853 | cell-based format | Scientific Literature | |
9. | ALA4361834 | Binding | Inhibition of CRM1 in human HuH7 cells assessed as accumulation of RIOK2 in nucleus at 0.1 to 10 uM measured after 6 hrs by DAPI staining based confocal microscopy analysis | Homo sapiens | 2 | ALA4359853 | cell-based format | Scientific Literature | |
10. | ALA4361836 | Binding | Inhibition of CRM1 in human HepG2 cells assessed as upregulation of p53 by measuring accumulation in nucleus at 0.1 to 10 uM measured after 6 to 24 hrs by DAPI staining based immunofluorescence microscopy analysis | Homo sapiens | 1 | ALA4359853 | cell-based format | Scientific Literature | |
11. | ALA4361837 | Binding | Inhibition of CRM1 in human HuH7 cells assessed as upregulation of p53 by measuring accumulation in nucleus at 0.1 to 10 uM measured after 24 to 48 hrs by DAPI staining based immunofluorescence microscopy analysis | Homo sapiens | 1 | ALA4359853 | cell-based format | Scientific Literature | |
12. | ALA940322 | Binding | Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy | 39 | ALA1152253 | cell-based format | Scientific Literature | ||
13. | ALA940323 | Binding | Inhibition of CRM1-mediated nucleocytoplasmic transport of HIV1 RevM5 mutant in human HeLa cells assessed as HIV1 RevM5-GFP nuclear localization at 25 nM after 2 hrs by fluorescence microscopy | 1 | ALA1152253 | cell-based format | Scientific Literature | ||
14. | ALA940324 | Binding | Inhibition of CRM1-mediated nucleocytoplasmic transport of HIV1 RevM5 mutant in human HeLa cells assessed as HIV1 RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy | 2 | ALA1152253 | cell-based format | Scientific Literature | ||
15. | ALA940330 | Binding | Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy | 39 | ALA1152253 | cell-based format | Scientific Literature | ||
16. | ALA941189 | Binding | Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy | 41 | ALA1152253 | cell-based format | Scientific Literature | ||
17. | ALA941190 | Binding | Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy | 46 | ALA1152253 | cell-based format | Scientific Literature | ||
18. | ALA3880038 | Binding | Inhibition of Crm1 in human U2OS cells expressing GFP-fused HIV1 Rev assessed as decrease in nuclear export of GFP-fused HIV1 Rev after 1 hr by Hoechst 33258 staining-based assay | Homo sapiens | 84 | ALA3879893 | cell-based format | Patent Bioactivity Data | |
19. | ALA3880074 | Binding | Inhibition of Crm1 in human H929 cells assessed as decrease in nuclear export of topoisomerase-2 by measuring caspase-3 levels at 0.1 to 10 uM preincubated for 16 hrs followed by addition of topoisomerase-2 inhibitor doxorubicin measured after 4 hrs by anti-caspase-3 assay | Homo sapiens | 1 | ALA3879893 | cell-based format | Patent Bioactivity Data | |
20. | ALA3880075 | Binding | Inhibition of Crm1 in human MM1S cells assessed as potentiation of bortezomib-induced antiproliferative activity by measuring cell survival at 30 to 300 nM after 72 hrs by MTT assay | Homo sapiens | 1 | ALA3879893 | cell-based format | Patent Bioactivity Data |