# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA940322 | B | Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy | 39 | cell-based format | Scientific Literature | |||
2. | ALA940323 | B | Inhibition of CRM1-mediated nucleocytoplasmic transport of HIV1 RevM5 mutant in human HeLa cells assessed as HIV1 RevM5-GFP nuclear localization at 25 nM after 2 hrs by fluorescence microscopy | 1 | cell-based format | Scientific Literature | |||
3. | ALA940324 | B | Inhibition of CRM1-mediated nucleocytoplasmic transport of HIV1 RevM5 mutant in human HeLa cells assessed as HIV1 RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy | 2 | cell-based format | Scientific Literature | |||
4. | ALA940330 | B | Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy | 39 | cell-based format | Scientific Literature | |||
5. | ALA941189 | B | Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy | 41 | cell-based format | Scientific Literature | |||
6. | ALA941190 | B | Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy | 46 | cell-based format | Scientific Literature | |||
7. | ALA1121233 | B | Inhibition of CRM1-mediated nuclear export of Rio2 in human HeLa cells at 2 uM | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
8. | ALA1110148 | B | Inhibition of CRM1-mediated nuclear export of Rio2 in human HeLa cells at 1 uM | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
9. | ALA1120676 | B | Inhibition of CRM1-mediated hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nuclear localization at 5 uM after 12 hrs by indirect fluorescent antibody technique | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA1120677 | B | Inhibition of CRM1-mediated hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization after 12 hrs by indirect fluorescent antibody technique | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
11. | ALA1120678 | B | Inhibition of CRM1-mediated hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization at 25 uM after 12 hrs by indirect fluorescent antibody technique | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
12. | ALA3880038 | B | Inhibition of Crm1 in human U2OS cells expressing GFP-fused HIV1 Rev assessed as decrease in nuclear export of GFP-fused HIV1 Rev after 1 hr by Hoechst 33258 staining-based assay | Homo sapiens | 84 | cell-based format | Patent Bioactivity Data | ||
13. | ALA3880074 | B | Inhibition of Crm1 in human H929 cells assessed as decrease in nuclear export of topoisomerase-2 by measuring caspase-3 levels at 0.1 to 10 uM preincubated for 16 hrs followed by addition of topoisomerase-2 inhibitor doxorubicin measured after 4 hrs by anti-caspase-3 assay | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
14. | ALA3880075 | B | Inhibition of Crm1 in human MM1S cells assessed as potentiation of bortezomib-induced antiproliferative activity by measuring cell survival at 30 to 300 nM after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
15. | ALA3880076 | B | Inhibition of Crm1 in human MM1R cells assessed as potentiation of bortezomib-induced antiproliferative activity by measuring cell survival at 30 to 300 nM after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
16. | ALA3880077 | B | Inhibition of Crm1 in human HS-Sultan cells assessed as potentiation of bortezomib-induced antiproliferative activity by measuring cell survival at 30 to 300 nM after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
17. | ALA3880078 | B | Inhibition of Crm1 in human Jurkat cells assessed as potentiation of bortezomib-induced antiproliferative activity by measuring cell survival at 30 to 300 nM after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
18. | ALA4024845 | B | Inhibition of CRM1-mediated nucleocytoplasmic transport in human HeLa cells after 90 mins by immunofluorescence assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
19. | ALA4057069 | B | Inhibition of CRM1-mediated nucleocytoplasmic transport of Riok2 in human HeLa cells at 1 uM after 90 mins by DAPI staining based microscopy relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
20. | ALA4057070 | B | Inhibition of CRM1-mediated nucleocytoplasmic transport of Riok2 in human HeLa cells at 5 uM after 90 mins by DAPI staining based microscopy relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature |