# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1032269 | B | Inhibition of CDKL2 at 3 uM | 1 | ALA1142492 | single protein format | Scientific Literature | ||
2. | ALA1052890 | B | Inhibition of CDKL2 assessed as enzyme activity at 1 uM relative to untreated control | 1 | ALA1155237 | single protein format | Scientific Literature | ||
3. | ALA1168826 | B | Inhibition of CDKL2 at 1 uM | 6 | ALA1165965 | single protein format | Scientific Literature | ||
4. | ALA1174171 | B | Inhibition of CDKL2 at 10 uM | 2 | ALA1177794 | single protein format | Scientific Literature | ||
5. | ALA1244764 | B | Binding affinity to CDKL2 | 7 | ALA1240346 | single protein format | Scientific Literature | ||
6. | ALA1775873 | B | Inhibition of CDKL2 at 1 uM | 1 | ALA1773016 | single protein format | Scientific Literature | ||
7. | ALA1826189 | B | Activity of CDKL2 kinase at 1 uM | 1 | ALA1821651 | single protein format | Scientific Literature | ||
8. | ALA1908625 | B | Binding constant for CDKL2 kinase domain | 72 | ALA1908390 | single protein format | Scientific Literature | ||
9. | ALA2209327 | B | Inhibition of CDKL2 assessed as residual activity at 10 uM relative to control | 1 | ALA2203081 | single protein format | Scientific Literature | ||
10. | ALA2439140 | B | Inhibition of human wild type CDKL2 at 1 uM by qPCR analysis relative to control | Homo sapiens | 1 | ALA2434948 | single protein format | Scientific Literature | |
11. | ALA3624239 | B | Inhibition of CDKL2 (unknown origin) at 10 uM | Homo sapiens | 1 | ALA3621108 | single protein format | Scientific Literature | |
12. | ALA3887934 | B | Competitive Binding Assay (KINOMEscan): For the competitive binding assay, test compounds were screened at 10 uM against 70 diverse kinase targets for competitive binding using the KINOMEscan technology (Ambit Biosciences) (Karaman, et al. (2008) Nature biotechnology 26:127-132). 11-point Kd curves were determined for hits identified during the initial screen. | 1 | ALA3886510 | single protein format | BindingDB Database | ||
13. | ALA4025061 | B | Inhibition of wild-type human partial length CDKL2 (M1 to D327 residues) expressed in bacterial expression system assessed as residual activity at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4024706 | assay format | Scientific Literature | |
14. | ALA4031394 | B | Inhibition of human CDKL2 (M1 to D327 residues) expressed in bacterial expression system assessed as residual activity at 1 uM by Kinomescan assay relative to control | Homo sapiens | 1 | ALA4028866 | assay format | Scientific Literature | |
15. | ALA4043872 | B | Inhibition of wild-type human partial length CDKL2 (M1 to D327 residues) expressed in Escherichia coli BL21 assessed as residual activity at 1000 nM after 30 mins by Kinomescan method relative to control | Homo sapiens | 1 | ALA4043093 | assay format | Scientific Literature | |
16. | ALA4055047 | B | Inhibition of wild-type human partial length CDKL2 (M1 to D327 residues) expressed in bacterial expression system assessed as residual activity at 50 nM by Kinomescan method relative to control | Homo sapiens | 2 | ALA4052645 | assay format | Scientific Literature | |
17. | ALA4118522 | B | Inhibition of human CDKL2 (1 to 327 residues) expressed in bacterial expression system assessed as enzyme activity at 1 uM by KINOMEScan assay relative to control | Homo sapiens | 1 | ALA4118021 | assay format | Scientific Literature | |
18. | ALA4119090 | B | Inhibition of human CDKL2 (1 to 327 residues) expressed in bacterial expression system assessed as enzyme activity at 10 uM by KINOMEScan assay relative to control | Homo sapiens | 1 | ALA4118021 | assay format | Scientific Literature | |
19. | ALA4156951 | B | Binding affinity to wild-type human partial length CDKL2 (M1 to D327 residues) expressed in bacterial expression system assessed as residual binding at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4152344 | assay format | Scientific Literature | |
20. | ALA4185730 | B | Binding affinity to wild-type human partial length CDKL2 (M1 to D327 residues) expressed in Escherichia coli BL21 at 1 uM by Kinomescan method relative to control | Homo sapiens | 2 | ALA4184148 | assay format | Scientific Literature |