# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1015294 | Functional | Agonist activity at human MrgX2 receptor | Homo sapiens | 7 | ALA1153297 | assay format | Scientific Literature | |
2. | ALA1015295 | Functional | Agonist activity at human MrgX2 receptor at 10 uM relative to cortistatin-14 | Homo sapiens | 12 | ALA1153297 | assay format | Scientific Literature | |
3. | ALA3721005 | Binding | Activation of human MrgX2 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assay | Homo sapiens | 10 | ALA3714739 | cell-based format | Patent Bioactivity Data | |
4. | ALA3721006 | Binding | Activation of human MrgX2 receptor expressed in NIH/3T3 cells incubated for 5 days by beta-galactosidase reporter gene assay relative to STIA | Homo sapiens | 10 | ALA3714739 | cell-based format | Patent Bioactivity Data | |
5. | ALA4613001 | Binding | Agonist activity at MRGPX2 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | ALA4610123 | single protein format | Scientific Literature | |
6. | ALA4613002 | Binding | Agonist activity at MRGPX2 (unknown origin) | Homo sapiens | 1 | ALA4610123 | single protein format | Scientific Literature | |
7. | ALA4883536 | Binding | PRESTO-Tango GPCRome screening (MRGPRX2) | 1 | ALA4507309 | single protein format | Donated Chemical Probes - SGC Frankfurt | ||
8. | ALA4884583 | Binding | PRESTO-Tango concentration response assay | Homo sapiens | 2 | ALA4507322 | single protein format | Donated Chemical Probes - SGC Frankfurt | |
9. | ALA4884584 | Binding | FLIPR assay | Homo sapiens | 2 | ALA4507322 | single protein format | Donated Chemical Probes - SGC Frankfurt | |
10. | ALA5042033 | Binding | Positive allosteric modulator activity at human MRGPRX2 transfected in HEK293 cells at 5 uM in presence of C48/80 by Fluo-4 AM-based FLIPR assay | Homo sapiens | 1 | ALA5038664 | cell-based format | Scientific Literature | |
11. | ALA5126027 | Functional | Antagonist activity at human MRGPRX2 expressed in HEK293 cells co-expressing mouse Galpha15 assessed as inhibition of Cortistatin-14 induced Ca2+ mobilization preincubated for 30 mins followed by Cortistatin-14 addition by FLIPRtetra-calcium mobilization assay | Homo sapiens | 6 | ALA5120954 | cell-based format | Scientific Literature | |
12. | ALA5133297 | Binding | Agonistic activity at MRGPRX2 (unknown origin) | Homo sapiens | 1 | ALA5131412 | single protein format | Scientific Literature | |
13. | ALA5133299 | Functional | Agonist activity at MRGPRX2 (unknown origin) expressed in HEK293 cells assessed as induction of G(o) dissociation by measuring luminescent decay at 10 uM by NanoBiT-G-protein dissociation assay | Homo sapiens | 1 | ALA5131412 | cell-based format | Scientific Literature | |
14. | ALA5133300 | Functional | Agonist activity at MRGPRX2 (unknown origin) expressed in HEK293 cells assessed as induction of G(o) dissociation by measuring luminescent decay at 32 uM by NanoBiT-G-protein dissociation assay | Homo sapiens | 2 | ALA5131412 | cell-based format | Scientific Literature | |
15. | ALA5141527 | Functional | Antagonist activity at MRGPRX2 (unknown origin) expressed in HEK293 cells assessed as inhibition of calcium mobilization at upto 10 uM | Homo sapiens | 3 | ALA5137071 | cell-based format | Scientific Literature | |
16. | ALA5145526 | Functional | Antagonist activity at MRGPRX2 (unknown origin) expressed in HEK293 cells assessed as inhibition of C48/80-induced Ca2+- mobilization | Homo sapiens | 2 | ALA5143572 | cell-based format | Scientific Literature | |
17. | ALA5210269 | Binding | Affinity On-target Cellular interaction (PRESTO-Tango concentration response assay (by the NIMH-PDSP)) EUB0000345a MRGPRX2 | Homo sapiens | 1 | ALA5210121 | single protein format | Literature data from EUbOPEN Chemogenomic Library | |
18. | ALA5210275 | Binding | Affinity On-target Cellular interaction (PRESTO-Tango concentration response assay (by the NIMH-PDSP)) EUB0000353a MRGPRX2 | Homo sapiens | 1 | ALA5210121 | single protein format | Literature data from EUbOPEN Chemogenomic Library | |
19. | ALA5214386 | Binding | Selectivity interaction (FLIPR assay) EUB0000345a MRGPRX2 | Homo sapiens | 1 | ALA5212743 | single protein format | Literature data from EUbOPEN Chemogenomic Library | |
20. | ALA5214421 | Binding | Selectivity interaction (FLIPR assay) EUB0000353a MRGPRX2 | Homo sapiens | 1 | ALA5212743 | single protein format | Literature data from EUbOPEN Chemogenomic Library |