# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3580088 | Binding | Agonist activity at TLR7 in mouse BMDM assessed as increase in IL-12 production at 2 uM after 24 hrs by ELISA in presence of BSA | Mus musculus | 1 | ALA3576817 | single protein format | Scientific Literature | |
2. | ALA3580089 | Binding | Agonist activity at TLR7 in mouse BMDM assessed as increase in IL-12 production at 2 uM after 24 hrs by ELISA in presence of OVA | Mus musculus | 1 | ALA3576817 | single protein format | Scientific Literature | |
3. | ALA3580090 | Binding | Agonist activity at TLR7 in mouse BMDM assessed as increase in IL-12 production at 2 uM after 24 hrs by ELISA in presence of MSA | Mus musculus | 1 | ALA3576817 | single protein format | Scientific Literature | |
4. | ALA3580091 | Binding | Agonist activity at TLR7 in mouse BMDM assessed as increase in IL-12 production at 2 uM after 24 hrs by ELISA in presence of MG7 | Mus musculus | 1 | ALA3576817 | single protein format | Scientific Literature | |
5. | ALA3580092 | Binding | Agonist activity at TLR7 in mouse BMDM assessed as increase in IL-12 production at 2 uM after 24 hrs by ELISA in presence of thymosin | Mus musculus | 1 | ALA3576817 | single protein format | Scientific Literature | |
6. | ALA3829203 | Binding | Agonist activity at TLR7 in Balb/c mouse splenocytes assessed as induction of IL-6 secretion in supernatant after 18 hrs | Mus musculus | 13 | ALA3826928 | cell-based format | Scientific Literature | |
7. | ALA3829204 | Binding | Agonist activity at TLR7 in Balb/c mouse splenocytes assessed as induction of IL-6 secretion in supernatant after 18 hrs relative to resiquimod | Mus musculus | 13 | ALA3826928 | cell-based format | Scientific Literature | |
8. | ALA3829207 | Binding | Agonist activity at TLR7 in Balb/c mouse splenocytes assessed as IL-6 level in supernatant after 18 hrs | Mus musculus | 1 | ALA3826928 | cell-based format | Scientific Literature | |
9. | ALA1226063 | Binding | Inhibition TLR7-mediated NO production in mouse RAW264.7 cells at 300 uM | Mus musculus | 1 | ALA1221358 | cell-based format | Scientific Literature | |
10. | ALA998615 | Binding | Induction of TLR7 receptor-mediated C57BL/6 mouse BMD cells activation assessed as upregulation of CD86 at 1 uM after 48 hrs by flow cytometry | Mus musculus | 10 | ALA1153992 | cell-based format | Scientific Literature | |
11. | ALA998616 | Binding | Induction of TLR7 receptor-mediated C57BL/6 mouse BMD cells activation assessed as upregulation of MHC class-2 at 1 uM after 48 hrs by flow cytometry | Mus musculus | 10 | ALA1153992 | cell-based format | Scientific Literature | |
12. | ALA998617 | Binding | Induction of TLR7 receptor-mediated C57BL/6 mouse BMD cells activation assessed as upregulation of CD40 at 1 uM after 48 hrs by flow cytometry | Mus musculus | 10 | ALA1153992 | cell-based format | Scientific Literature | |
13. | ALA998618 | Binding | Induction of TLR7 receptor-mediated C57BL/6 mouse BMD cells activation assessed as IL12 production at 5 uM after 24 hrs by ELISA | Mus musculus | 9 | ALA1153992 | cell-based format | Scientific Literature | |
14. | ALA998619 | Binding | Induction of TLR7 receptor-mediated C57BL/6 mouse BMD cells activation assessed as IL12 production at 0.1 uM after 24 hrs by ELISA | Mus musculus | 2 | ALA1153992 | cell-based format | Scientific Literature | |
15. | ALA998620 | Binding | Induction of TLR7 receptor-mediated C57BL/6 mouse BMD cells activation assessed as IL12 production at 10 nM after 24 hrs by ELISA | Mus musculus | 1 | ALA1153992 | cell-based format | Scientific Literature | |
16. | ALA2150095 | Binding | Activation of TLR7 in C57BL/6 mouse bone marrow dendritic cells assessed as increase of IL6 production after 24 hrs by ELISA | Mus musculus | 1 | ALA2146475 | cell-based format | Scientific Literature | |
17. | ALA2321101 | Binding | Agonist activity at mouse TLR7 | Mus musculus | 2 | ALA2311334 | single protein format | Scientific Literature | |
18. | ALA3881378 | Binding | Antagonist activity at TLR7 in mouse RAW264.7 cells assessed as inhibition of R848-induced receptor activation by measuring NO production at 3 uM after 24 hrs | Mus musculus | 1 | ALA3880440 | cell-based format | Patent Bioactivity Data | |
19. | ALA3881382 | Binding | Antagonist activity at TLR7 in mouse RAW264.7 cells assessed as inhibition of R848-induced receptor activation by measuring NO production at 0.5 uM after 24 hrs | Mus musculus | 1 | ALA3880440 | cell-based format | Patent Bioactivity Data | |
20. | ALA4030718 | Binding | Agonist activity at mouse TLR7 expressed in HEK293 cells after 6 hrs by NFkappaB-luciferase reporter gene assay | Mus musculus | 1 | ALA4028850 | cell-based format | Scientific Literature |