# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA986818 | B | Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as outward-inward rectifying current at <10 uM by whole cell patch clamp assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
2. | ALA986819 | F | Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration at 500 uM in presence of TRP antagonist ruthenium red | Mus musculus | 1 | cell-based format | Scientific Literature | ||
3. | ALA986820 | B | Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration | Mus musculus | 10 | cell-based format | Scientific Literature | ||
4. | ALA988582 | B | Activation of mouse TRPV4 Y556A mutant expressed in HEK293 cells assessed as increase in intracellular calcium concentration | Mus musculus | 3 | cell-based format | Scientific Literature | ||
5. | ALA988583 | B | Activation of mouse TRPV4 S557A mutant expressed in HEK293 cells assessed as increase in intracellular calcium concentration | Mus musculus | 3 | cell-based format | Scientific Literature | ||
6. | ALA988584 | B | Activation of mouse TRPV4 W586A mutant expressed in HEK293 cells assessed as increase in intracellular calcium concentration | Mus musculus | 3 | cell-based format | Scientific Literature | ||
7. | ALA988587 | F | Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration at 1 uM in presence of TRP antagonist ruthenium red | Mus musculus | 1 | cell-based format | Scientific Literature | ||
8. | ALA988588 | B | Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration at 0.1 uM | Mus musculus | 1 | cell-based format | Scientific Literature | ||
9. | ALA988593 | B | Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration at 500 uM | Mus musculus | 1 | cell-based format | Scientific Literature | ||
10. | ALA988594 | B | Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as outward-inward rectifying current density at 500 nM at a holding potential of 100 mV by whole cell patch-clamp assay in presence of calcium | Mus musculus | 2 | cell-based format | Scientific Literature | ||
11. | ALA988595 | B | Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as outward-inward rectifying current density at 500 nM at a holding potential of 100 mV by whole cell patch-clamp assay in absence of calcium | Mus musculus | 2 | cell-based format | Scientific Literature | ||
12. | ALA988596 | F | Agonist activity at mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium measured by fura-2 fluorescence ratio | Mus musculus | 1 | cell-based format | Scientific Literature | ||
13. | ALA988597 | F | Agonist activity at mouse TRPV4 Y556A mutant expressed in HEK293 cells assessed as increase in intracellular calcium measured by fura-2 fluorescence ratio | Mus musculus | 1 | cell-based format | Scientific Literature | ||
14. | ALA988598 | F | Agonist activity at mouse TRPV4 S557A mutant expressed in HEK293 cells assessed as increase in intracellular calcium measured by fura-2 fluorescence ratio | Mus musculus | 1 | cell-based format | Scientific Literature | ||
15. | ALA993745 | F | Agonist activity at mouse TRPV4 W586A mutant expressed in HEK293 cells assessed as increase in intracellular calcium measured by fura-2 fluorescence ratio | Mus musculus | 1 | cell-based format | Scientific Literature | ||
16. | ALA3615626 | B | Antagonist activity at mouse TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 mins | Mus musculus | 1 | cell-based format | Scientific Literature | ||
17. | ALA3615627 | B | Antagonist activity at mouse TRPV4 receptor expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-stimulated calcium flux after 10 mins | Mus musculus | 1 | cell-based format | Scientific Literature | ||
18. | ALA3997756 | B | Antagonist activity at mouse TRPV4 expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-induced current at holding potential of -40 mV by Whole cell patch-clamp method | Mus musculus | 1 | cell-based format | Scientific Literature | ||
19. | ALA3997759 | B | Antagonist activity at mouse TRPV4 expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-induced intracellular calcium after 10 mins in presence of 45Ca2+ by microbeta liquid scintillation counting method | Mus musculus | 1 | cell-based format | Scientific Literature | ||
20. | ALA4377087 | B | Inhibition of YFP-tagged mouse TRPV4 expressed in HEK293 cells assessed as reduction in calcium level by fluo-4 dye based fluorescence assay | Mus musculus | 1 | cell-based format | Scientific Literature |