# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3615626 | Binding | Antagonist activity at mouse TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 mins | Mus musculus | 1 | ALA3612012 | cell-based format | Scientific Literature | |
2. | ALA3615627 | Binding | Antagonist activity at mouse TRPV4 receptor expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-stimulated calcium flux after 10 mins | Mus musculus | 1 | ALA3612012 | cell-based format | Scientific Literature | |
3. | ALA986818 | Binding | Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as outward-inward rectifying current at <10 uM by whole cell patch clamp assay | Mus musculus | 1 | ALA1138474 | cell-based format | Scientific Literature | |
4. | ALA986819 | Functional | Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration at 500 uM in presence of TRP antagonist ruthenium red | Mus musculus | 1 | ALA1138474 | cell-based format | Scientific Literature | |
5. | ALA986820 | Binding | Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration | Mus musculus | 10 | ALA1138474 | cell-based format | Scientific Literature | |
6. | ALA988582 | Binding | Activation of mouse TRPV4 Y556A mutant expressed in HEK293 cells assessed as increase in intracellular calcium concentration | Mus musculus | 3 | ALA1138474 | cell-based format | Scientific Literature | |
7. | ALA988583 | Binding | Activation of mouse TRPV4 S557A mutant expressed in HEK293 cells assessed as increase in intracellular calcium concentration | Mus musculus | 3 | ALA1138474 | cell-based format | Scientific Literature | |
8. | ALA988584 | Binding | Activation of mouse TRPV4 W586A mutant expressed in HEK293 cells assessed as increase in intracellular calcium concentration | Mus musculus | 3 | ALA1138474 | cell-based format | Scientific Literature | |
9. | ALA988587 | Functional | Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration at 1 uM in presence of TRP antagonist ruthenium red | Mus musculus | 1 | ALA1138474 | cell-based format | Scientific Literature | |
10. | ALA988588 | Binding | Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration at 0.1 uM | Mus musculus | 1 | ALA1138474 | cell-based format | Scientific Literature | |
11. | ALA988593 | Binding | Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration at 500 uM | Mus musculus | 1 | ALA1138474 | cell-based format | Scientific Literature | |
12. | ALA988594 | Binding | Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as outward-inward rectifying current density at 500 nM at a holding potential of 100 mV by whole cell patch-clamp assay in presence of calcium | Mus musculus | 2 | ALA1138474 | cell-based format | Scientific Literature | |
13. | ALA988595 | Binding | Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as outward-inward rectifying current density at 500 nM at a holding potential of 100 mV by whole cell patch-clamp assay in absence of calcium | Mus musculus | 2 | ALA1138474 | cell-based format | Scientific Literature | |
14. | ALA988596 | Functional | Agonist activity at mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium measured by fura-2 fluorescence ratio | Mus musculus | 1 | ALA1138474 | cell-based format | Scientific Literature | |
15. | ALA988597 | Functional | Agonist activity at mouse TRPV4 Y556A mutant expressed in HEK293 cells assessed as increase in intracellular calcium measured by fura-2 fluorescence ratio | Mus musculus | 1 | ALA1138474 | cell-based format | Scientific Literature | |
16. | ALA988598 | Functional | Agonist activity at mouse TRPV4 S557A mutant expressed in HEK293 cells assessed as increase in intracellular calcium measured by fura-2 fluorescence ratio | Mus musculus | 1 | ALA1138474 | cell-based format | Scientific Literature | |
17. | ALA993745 | Functional | Agonist activity at mouse TRPV4 W586A mutant expressed in HEK293 cells assessed as increase in intracellular calcium measured by fura-2 fluorescence ratio | Mus musculus | 1 | ALA1138474 | cell-based format | Scientific Literature | |
18. | ALA3997756 | Binding | Antagonist activity at mouse TRPV4 expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-induced current at holding potential of -40 mV by Whole cell patch-clamp method | Mus musculus | 1 | ALA3994677 | cell-based format | Scientific Literature | |
19. | ALA3997759 | Binding | Antagonist activity at mouse TRPV4 expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-induced intracellular calcium after 10 mins in presence of 45Ca2+ by microbeta liquid scintillation counting method | Mus musculus | 1 | ALA3994677 | cell-based format | Scientific Literature | |
20. | ALA4377087 | Binding | Inhibition of YFP-tagged mouse TRPV4 expressed in HEK293 cells assessed as reduction in calcium level by fluo-4 dye based fluorescence assay | Mus musculus | 1 | ALA4376804 | cell-based format | Scientific Literature |