| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2045988 | B | Inhibition of PHD3 | 56 | single protein format | Scientific Literature | |||
| 2. | ALA946279 | B | Inhibition of human recombinant HIF PHD3 | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 3. | ALA1243626 | B | Activity of HIF prolyl hydroxylase-3 | 3 | single protein format | Scientific Literature | |||
| 4. | ALA1942544 | B | Inhibition of PHD3 | 1 | single protein format | Scientific Literature | |||
| 5. | ALA3118411 | B | Inhibition of recombinant PHD3 (unknown origin) expressed in Escherichia coli cells using FITC-labeled ACA-DLDLEALAPYIPADDDFQLR as substrate after 1 hr by fluorescence polarization assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA3118613 | B | Inhibition of PHD3 (unknown origin) expressed in Sf9 cells using HIF-1alpha peptide as substrate preincubated for 30 mins followed by substrate addition measured after 2 hrs by HTRF assay in presence of 2-oxoglutarate | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA3118622 | B | Inhibition of full length human recombinant EGLN-3 using DLDLEALAPYIPADDDFQL as substrate after 20 mins by mass spectrophotometric analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 8. | ALA3119779 | B | Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli preincubated for 3 mins followed by substrate addition measured after 30 mins | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 9. | ALA3119780 | B | Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISA | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 10. | ALA3119781 | B | Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli after 30 mins | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 11. | ALA3137096 | B | Inhibition of PHD3 in human NCI-H446 cells grown under normoxia assessed as HIF1alpha accumulation measured as increase in VEGF protein expression at 25 uM after 12 hrs by ELISA relative to untreated control | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 12. | ALA3137097 | B | Inhibition of PHD3 in human NCI-H446 cells grown under normoxia assessed as HIF1alpha accumulation measured as increase in GLUT1 protein expression at 25 uM after 12 hrs by Western blot analysis relative to untreated control | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 13. | ALA3137098 | B | Inhibition of PHD3 in human NCI-H446 cells grown under normoxia assessed as HIF1alpha accumulation measured as increase in VEGF gene expression at 25 uM after 12 hrs by RT-PCR analysis relative to untreated control | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 14. | ALA3137099 | B | Inhibition of PHD3 in human NCI-H446 cells grown under normoxia assessed as HIF1alpha accumulation measured as increase in GLUT1 gene expression at 25 uM after 12 hrs by RT-PCR analysis relative to untreated control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA3137101 | B | Inhibition of PHD3 in human NCI-H446 cells grown under normoxia assessed as increase in HIF1alpha protein level after 12 hrs by Western blot analysis relative to untreated control | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 16. | ALA3137104 | B | Inhibition of recombinant human PHD3 core domain assessed as stabilization of protein after 24 hrs by MALDI-MS spectrometry in presence of trypsin | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 17. | ALA3137105 | B | Inhibition of recombinant human PHD3 core domain assessed as stabilization of protein up to 14 hrs by MALDI-MS spectrometry in presence of trypsin | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 18. | ALA3137106 | B | Inhibition of recombinant human PHD3 core domain assessed as stabilization of protein up to 3 hrs by MALDI-MS spectrometry in presence of trypsin | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 19. | ALA3137107 | B | Inhibition of recombinant human PHD3-Fe2+ -NOG complex expressed in Escherichia coli assessed as conformational change at 50 uM after 20 mins by CD spectrometry | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 20. | ALA3137108 | B | Inhibition of recombinant human PHD3-Fe2+ complex expressed in Escherichia coli assessed as conformational change at 50 uM after 20 mins by CD spectrometry | Homo sapiens | 6 | assay format | Scientific Literature |
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