| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1908638 | B | Binding constant for CDKL1 kinase domain | 72 | single protein format | Scientific Literature | |||
| 2. | ALA1022595 | B | Inhibition of CDK1 | 1 | single protein format | Scientific Literature | |||
| 3. | ALA1174170 | B | Inhibition of CDKL1 at 10 uM | 2 | single protein format | Scientific Literature | |||
| 4. | ALA1769030 | B | Binding affinity to human CDKL1 assessed as residual binding at 1 uM by site dependent competitive binding assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 5. | ALA2209329 | B | Inhibition of CDKL1 assessed as residual activity at 10 uM relative to control | 1 | single protein format | Scientific Literature | |||
| 6. | ALA3112116 | B | Inhibition of CDKL1 (unknown origin) assessed as residual activity at 10 uM after 1 hr by qPCR analysis relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA3430800 | B | Delta TM value showing the stabilisation of CDKL1 produced by compound binding | Homo sapiens | 156 | single protein format | Scientific Literature | ||
| 8. | ALA4025060 | B | Inhibition of wild-type human full length CDKL1 (M1 to I358 residues) expressed in mammalian expression system assessed as residual activity at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 9. | ALA4043871 | B | Inhibition of wild-type human full length CDKL1 (M1 to I358 residues) expressed in HEK293 cells assessed as residual activity at 1000 nM after 30 mins by Kinomescan method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4055128 | B | Inhibition of wild-type human full length CDKL1 (M1 to I358 residues) expressed in mammalian expression system assessed as residual activity at 50 nM by Kinomescan method relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 11. | ALA4156950 | B | Binding affinity to wild-type human full length CDKL1 (M1 to I358 residues) expressed in mammalian expression system assessed as residual binding at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 12. | ALA4185729 | B | Binding affinity to wild-type human full length CDKL1 (M1 to I358 residues) expressed in HEK293 cells at 1 uM by Kinomescan method relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA4190907 | B | Inhibition of recombinant human CDKL1 (1 to 303 residues) at 1 uM using RRRFRPASPLRGPPK as substrate after 120 mins in presence of [gamma-33P]ATP by scintillation counting method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA4230629 | B | Binding affinity to wild-type human full length CDKL1 (M1 to I358 residues) expressed in mammalian expression system assessed as residual binding level at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 15. | ALA4264218 | B | Binding affinity to wild-type human full length CDKL1 (M1 to I358 residues) expressed in mammalian expression system assessed as remaining unbound target protein level at 1000 nM by Kinomescan method relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 16. | ALA4307733 | B | Binding affinity to wild-type human full length CDKL1 (M1 to I358 residues) expressed in mammalian expression system assessed as residual binding level at 10 uM by Kinomescan method relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 17. | ALA4314622 | B | Inhibition of recombinant human CDKL1 (1 to 303 residues) assessed as residual activity at 10 uM using RRRFRPASPLRGP as substrate measured after 120 mins in presence of [gamma33P]ATP by scintillation counting method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 18. | ALA4333324 | B | Binding affinity to wild-type human full length CDKL1 (M1 to I358 residues) expressed in mammalian expression system assessed as residual binding level at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 19. | ALA4335014 | B | Inhibition of recombinant human CDKL1 (1 to 303 residues) assessed as residual activity at 1 uM using RRRFRPASPLRGP as substrate measured after 120 mins in presence of [gamma33P]ATP by scintillation counting method | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 20. | ALA4336842 | B | Inhibition of recombinant full length human CDKL1 assessed as residual activity at 10 uM using RRRFRPASPLRGP as substrate incubated for 120 mins in presence of [gamma-33ATP] by scintillation counting based radiometry assay relative to control | Homo sapiens | 1 | single protein format | Scientific Literature |
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