| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2020654 | F | Agonist activity at human TLR8 expressed in HEK-Blue cells assessed as increase in NFkappaB activation by sAP reporter gene assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 2. | ALA2020655 | F | Antagonist activity at human TLR8 expressed in HEK-Blue cells assessed as inhibition of CL075-induced NFkappaB activation by sAP reporter gene assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 3. | ALA2020658 | F | Antagonist activity at TLR8 in human PBMC assessed as inhibition of CL075-TNF-alpha release after 12 hrs by bead array assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 4. | ALA2020659 | F | Antagonist activity at TLR8 in human PBMC assessed as inhibition of CL075-induced IL-6 release after 12 hrs by bead array assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 5. | ALA2020660 | F | Antagonist activity at TLR8 in human PBMC assessed as inhibition of CL075-induced IL-8 release after 12 hrs by bead array assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 6. | ALA2020661 | B | Competitive inhibition of human TLR8 expressed in HEK-Blue cells by schild plot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA2020667 | F | Antagonist activity at TLR8 in human PBMC assessed as inhibition of CL075-induced IL-1beta release after 12 hrs by bead array assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 8. | ALA2020668 | F | Antagonist activity at TLR8 in human PBMC assessed as inhibition of CL075-induced CXCL10 release after 12 hrs by bead array assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 9. | ALA2020669 | F | Antagonist activity at TLR8 in human PBMC assessed as inhibition of CL075-induced CCL2 release after 12 hrs by bead array assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 10. | ALA978827 | B | Activation of human TLR8 expressed in HEK293 cells assessed as increase in NF-kappaB activation at 100 ug/ml by SEAP assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 11. | ALA992621 | F | Agonist activity at human TLR8 expressed in HEK cells by NF-kappaB luciferase reporter gene assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA992622 | F | Agonist activity at TLR8 in human PBMC cells assessed as TNFalpha level by ELISA | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA1023609 | F | Agonist activity at human TLR8 expressed in HEK293XL cells assessed as NF-kappaB activation after 18 hrs | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 14. | ALA1102309 | B | Activation of human TLR8 expressed in HEK293XL assessed as fold induction of NF-kappaB activity at 50 ug/ml after 18 hrs by reporter gene assay relative to control | Homo sapiens | 32 | assay format | Scientific Literature | ||
| 15. | ALA1102314 | B | Activation of human TLR8 expressed in HEK293XL assessed as induction of NF-kappaB activity by reporter gene assay | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 16. | ALA1103539 | F | Agonist activity at TLR8 | 1 | assay format | Scientific Literature | |||
| 17. | ALA1120542 | F | Agonist activity at human TLR8 expressed in NF-kappaB-stimulated HEK293 cells assessed as induction of secreted alkaline phosphatase expression by reporter gene assay | Homo sapiens | 34 | cell-based format | Scientific Literature | ||
| 18. | ALA2187099 | F | Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline phosphatase by HEK-blue reporter gene assay | Homo sapiens | 27 | cell-based format | Scientific Literature | ||
| 19. | ALA2187101 | F | Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline phosphatase up to 250 uM by HEK-blue reporter gene assay | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 20. | ALA2216966 | F | Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay | Homo sapiens | 6 | cell-based format | Scientific Literature |
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