# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1108872 | Binding | Displacement of [125I]exendin-4 from GLP1 receptor in rat RINm5F cells after 2 hrs by gamma counting | Rattus norvegicus | 8 | ALA1156248 | cell-based format | Scientific Literature | |
2. | ALA1108873 | Binding | Displacement of [125I]exendin-4 from GLP1 receptor in rat RINm5F cells at 10 nM after 2 hrs by gamma counting | Rattus norvegicus | 8 | ALA1156248 | cell-based format | Scientific Literature | |
3. | ALA1108874 | Binding | Ratio of compound IC50 to exendin-4 IC50 for GLP1 receptor in rat RINm5F cells | Rattus norvegicus | 4 | ALA1156248 | cell-based format | Scientific Literature | |
4. | ALA1108875 | Binding | Displacement of [125I]exendin-4 from GLP1 receptor in rat RINm5F cells at 0.001 to 1000 nM after 2 hrs by gamma counting | Rattus norvegicus | 3 | ALA1156248 | cell-based format | Scientific Literature | |
5. | ALA996044 | Functional | Agonist activity at rat GLP1 receptor expressed in HEK293 cells assessed as luciferase activity | Rattus norvegicus | 1 | ALA1156434 | cell-based format | Scientific Literature | |
6. | ALA996045 | Functional | Agonist activity at rat GLP1 receptor expressed in HEK293 cells assessed as cAMP release | Rattus norvegicus | 3 | ALA1156434 | cell-based format | Scientific Literature | |
7. | ALA996874 | Binding | Displacement of [125I]GLP1 from rat GLP1 receptor expressed in HEK293 cells | Rattus norvegicus | 3 | ALA1156434 | cell-based format | Scientific Literature | |
8. | ALA996875 | Functional | Agonist activity at rat GLP1 receptor expressed in HEK293 cells assessed as luciferase activity upto 10 uM relative to GLP1 | Rattus norvegicus | 2 | ALA1156434 | cell-based format | Scientific Literature | |
9. | ALA996877 | Functional | Reversal of agonist activity at rat GLP1 receptor expressed in HEK293 cells assessed as luciferase activity at 10 uM in presence of exendin | Rattus norvegicus | 2 | ALA1156434 | cell-based format | Scientific Literature | |
10. | ALA996878 | Functional | Reversal of agonist activity at rat GLP1 receptor expressed in HEK293 cells assessed as luciferase activity at 0.05 uM in presence of exendin | Rattus norvegicus | 2 | ALA1156434 | cell-based format | Scientific Literature | |
11. | ALA2161789 | Binding | Inhibition of [125I]GLP1 (7-36) amide binding to rat GLP1R expressed in HEK293 cells relative to untreated control | Rattus norvegicus | 54 | ALA2157924 | cell-based format | Scientific Literature | |
12. | ALA2161790 | Binding | Inhibition of [125I]Exendin (9-39) binding to rat GLP1R expressed in HEK293 cells | Rattus norvegicus | 54 | ALA2157924 | cell-based format | Scientific Literature | |
13. | ALA2161791 | Binding | Inhibition of [125I]GLP1 (7-36) amide binding to rat GLP1R expressed in HEK293 cells | Rattus norvegicus | 54 | ALA2157924 | cell-based format | Scientific Literature | |
14. | ALA2161792 | Functional | Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP response element (MRE/CRE)-driven reporter gene assay relative to 10 nM GLP1 | Rattus norvegicus | 54 | ALA2157924 | cell-based format | Scientific Literature | |
15. | ALA2161793 | Functional | Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP response element (MRE/CRE)-driven reporter gene assay | Rattus norvegicus | 54 | ALA2157924 | cell-based format | Scientific Literature | |
16. | ALA3994847 | Binding | Agonist activity at GLP1R in rat INS-1 cells assessed as increase in glucose-stimulated insulin secretion after 1 hr by HTRF assay | Rattus norvegicus | 7 | ALA3994575 | cell-based format | Scientific Literature | |
17. | ALA4713470 | Functional | Agonist activity at rat GLP-1R expressed in HEK293 cells assessed as stimulation of cAMP accumulation by FRET assay | Rattus norvegicus | 2 | ALA4706662 | cell-based format | Scientific Literature | |
18. | ALA5122362 | Functional | Activation of GLP-1 receptor in rat INS-1 cells assessed as cAMP accumulation at 10 nmol/L time-resolved fluorescence resonance energy transfer immunoassay | Rattus norvegicus | 2 | ALA5120806 | cell-based format | Scientific Literature | |
19. | ALA5163168 | Binding | Positive allosteric modulator activity at GLP-1R in rat INS1 beta-cells assessed potentiation of GLP-1(7-36)NH2 induced insulin secretion at 1 uM incubated for 30 mins in presence of 15 mM of glucose by ELISA | Rattus norvegicus | 4 | ALA5154825 | cell-based format | Scientific Literature | |
20. | ALA5163170 | Binding | Positive allosteric modulator activity at GLP-1R in rat INS1 beta-cells assessed potentiation of GLP-1(7-36)NH2 induced insulin secretion incubated for 30 mins in presence of high glucose condition by ELISA | Rattus norvegicus | 1 | ALA5154825 | cell-based format | Scientific Literature |