| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1837699 | F | Agonist activity at TLR7 in human PBMC assessed as induction of type 1 interferon production | Homo sapiens | 19 | assay format | Scientific Literature | ||
| 2. | ALA1837700 | F | Agonist activity at TLR7 | 15 | assay format | Scientific Literature | |||
| 3. | ALA2025431 | F | Agonist activity at TLR7 | 2 | assay format | Scientific Literature | |||
| 4. | ALA2025450 | F | Agonist activity at human TLR7 expressed in human PBMCs assessed as reduction in HCV replicon level after 48 hrs by Bright Glo luciferase reporter gene assay | Homo sapiens | 16 | assay format | Scientific Literature | ||
| 5. | ALA2020652 | F | Agonist activity at human TLR7 expressed in HEK-Blue cells assessed as increase in NFkappaB activation by sAP reporter gene assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 6. | ALA2020653 | F | Antagonist activity at human TLR7 expressed in HEK-Blue cells assessed as inhibition of gardiquimod-induced NFkappaB activation by sAP reporter gene assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 7. | ALA2020657 | F | Antagonist activity at TLR7 in human PBMC assessed as inhibition of gardiquimod-induced IL-8 release after 12 hrs by bead array assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 8. | ALA2020662 | F | Antagonist activity at TLR7 in human PBMC assessed as inhibition of gardiquimod-induced IL-6 release after 12 hrs by bead array assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 9. | ALA2020663 | F | Antagonist activity at TLR7 in human PBMC assessed as inhibition of gardiquimod-induced TNF-alpha release after 12 hrs by bead array assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 10. | ALA2020664 | F | Antagonist activity at TLR7 in human PBMC assessed as inhibition of gardiquimod-induced IL-1beta release after 12 hrs by bead array assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 11. | ALA2020665 | F | Antagonist activity at TLR7 in human PBMC assessed as inhibition of gardiquimod-induced CXCL10 release after 12 hrs by bead array assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 12. | ALA2020666 | F | Antagonist activity at TLR7 in human PBMC assessed as inhibition of gardiquimod-induced CCL2 release after 12 hrs by bead array assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 13. | ALA1799010 | F | Antagonist activity at TLR7 expressed in HEK293 cells co-transfected with NF-kappaB/sAP gene assessed as inhibition of 250 ug/ml of gardiquimod-induced NF-kappaB activation by reporter gene assay | 1 | cell-based format | Scientific Literature | |||
| 14. | ALA1799011 | F | Antagonist activity at TLR7 expressed in HEK293 cells co-transfected with NF-kappaB/sAP gene assessed as inhibition of 1 ug/ml of gardiquimod-induced NF-kappaB activation by reporter gene assay | 13 | cell-based format | Scientific Literature | |||
| 15. | ALA1799012 | F | Antagonist activity at TLR8 expressed in HEK293 cells co-transfected with NF-kappaB/sAP gene assessed as inhibition of CL075-induced NF-kappaB activation by reporter gene assay | 21 | cell-based format | Scientific Literature | |||
| 16. | ALA1799013 | F | Antagonist activity at TLR7 expressed in HEK293 cells co-transfected with NF-kappaB/sAP gene assessed as inhibition of gardiquimod-induced NF-kappaB activation at 250 uM by reporter gene assay | 9 | cell-based format | Scientific Literature | |||
| 17. | ALA1799014 | F | Antagonist activity at TLR8 expressed in HEK293 cells co-transfected with NF-kappaB/sAP gene assessed as inhibition of CL075-induced NF-kappaB activation at 250 uM by reporter gene assay | 2 | cell-based format | Scientific Literature | |||
| 18. | ALA2148736 | F | Antagonist activity at TLR7 expressed in HEK293 cells co-transfected with NF-kappaB/sAP gene assessed as inhibition of gardiquimod-induced NF-kappaB activation up to 250 uM by reporter gene assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 19. | ALA2148737 | F | Agonist activity at human TLR7 expressed in HEK293 cells co-transfected with NF-kappaB/sAP gene assessed as induction of NF-kappaB activation up to 250 uM by reporter gene assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 20. | ALA975306 | F | Agonist activity at TLR7 expressed in HEK293 cells assessed as increase in NF-kappaB activation by SEAP assay | 1 | cell-based format | Scientific Literature |
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