# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA975306 | F | Agonist activity at TLR7 expressed in HEK293 cells assessed as increase in NF-kappaB activation by SEAP assay | 1 | ALA1153973 | cell-based format | Scientific Literature | ||
2. | ALA975307 | F | Agonist activity at TLR7 expressed in HEK293 cells assessed as increase in NF-kappaB activation at 25 ug/mL by SEAP assay | 1 | ALA1153973 | cell-based format | Scientific Literature | ||
3. | ALA975308 | F | Antagonist activity at TLR7 expressed in HEK293 cells by spectrophotometry in presence of 250 ng/mL gardiquimod | 2 | ALA1153973 | cell-based format | Scientific Literature | ||
4. | ALA978828 | B | Activation of human TLR7 expressed in HEK293 cells assessed as increase in NF-kappaB activation at 100 ug/ml by SEAP assay | Homo sapiens | 10 | ALA1156502 | cell-based format | Scientific Literature | |
5. | ALA992619 | F | Agonist activity at human TLR7 by luciferase reporter gene assay | Homo sapiens | 11 | ALA1142478 | assay format | Scientific Literature | |
6. | ALA992620 | F | Agonist activity at TLR7 in human PBMC cells assessed as stimulation of interferon release | Homo sapiens | 2 | ALA1142478 | cell-based format | Scientific Literature | |
7. | ALA1023610 | F | Agonist activity at human TLR7 expressed in HEK293XL cells assessed as NF-kappaB activation after 18 hrs | Homo sapiens | 4 | ALA1151840 | cell-based format | Scientific Literature | |
8. | ALA1023611 | F | Agonist activity at human TLR7 expressed in HEK293XL cells assessed as NF-kappaB activation at 300 ug/ml after 18 hrs | Homo sapiens | 3 | ALA1151840 | cell-based format | Scientific Literature | |
9. | ALA1102308 | B | Activation of human TLR7 expressed in HEK293XL assessed as fold induction of NF-kappaB activity at 50 ug/ml after 18 hrs by reporter gene assay relative to control | Homo sapiens | 32 | ALA1154352 | assay format | Scientific Literature | |
10. | ALA1102313 | B | Activation of human TLR7 expressed in HEK293XL assessed as induction of NF-kappaB activity by reporter gene assay | Homo sapiens | 4 | ALA1154352 | assay format | Scientific Literature | |
11. | ALA1103537 | F | Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assay | Homo sapiens | 16 | ALA1156980 | cell-based format | Scientific Literature | |
12. | ALA1120541 | F | Agonist activity at human TLR7 expressed in NF-kappaB-stimulated HEK293 cells assessed as induction of secreted alkaline phosphatase expression by reporter gene assay | Homo sapiens | 18 | ALA1158593 | cell-based format | Scientific Literature | |
13. | ALA1120544 | F | Agonist activity at human TLR7 expressed in NF-kappaB-stimulated HEK293 cells assessed as induction of secreted alkaline phosphatase expression at 100 uM by reporter gene assay | Homo sapiens | 16 | ALA1158593 | cell-based format | Scientific Literature | |
14. | ALA1247825 | B | Inhibition of TLR7-mediated upregulation of IRAK4 expression in aldrithiol-2-treated HIV1 Ada-stimulated human PBMC at 100 uM after 20 hrs by flow cytometry | Homo sapiens | 1 | ALA1240368 | assay format | Scientific Literature | |
15. | ALA1247826 | B | Inhibition of TLR7-mediated upregulation of IRAK4 expression in aldrithiol-2-treated HIV1 MN-stimulated human PBMC at 100 uM after 20 hrs by flow cytometry | Homo sapiens | 1 | ALA1240368 | assay format | Scientific Literature | |
16. | ALA1247827 | B | Inhibition of TLR7-mediated upregulation of IRF7 expression in aldrithiol-2-treated HIV1 Ada-stimulated human PBMC at 100 uM after 20 hrs by flow cytometry | Homo sapiens | 1 | ALA1240368 | assay format | Scientific Literature | |
17. | ALA1247828 | B | Inhibition of TLR7-mediated upregulation of IRF7 expression in aldrithiol-2-treated HIV1 MN-stimulated human PBMC at 100 uM after 20 hrs by flow cytometry | Homo sapiens | 1 | ALA1240368 | assay format | Scientific Literature | |
18. | ALA1248009 | B | Inhibition of TLR7-mediated IFN-gamma production in aldrithiol-2-treated HIV1 Ada-stimulated human PBMC at 100 uM after 20 hrs by ELISA | Homo sapiens | 1 | ALA1240368 | single protein format | Scientific Literature | |
19. | ALA1248010 | B | Inhibition of TLR7-mediated IFN-gamma production in aldrithiol-2-treated HIV1 MN-stimulated human PBMC at 100 uM after 20 hrs by ELISA | Homo sapiens | 1 | ALA1240368 | single protein format | Scientific Literature | |
20. | ALA1248013 | B | Inhibition of TLR7-mediated IFN-gamma production in aldrithiol-2-treated HIV1 Ada-stimulated human PBMC after 20 hrs by ELISA | Homo sapiens | 1 | ALA1240368 | single protein format | Scientific Literature |