| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3540842 | ADME | Activity of human CYP2C8 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated 2-mercapto-3-(4-((6-methoxy-1-methyl-1H-benzo[d]imidazol-2-yl)methoxy)phenyl)propanoic acid formation at 20 uM after 2 hrs by radio-HPLC/LC-MS/MS analysis in presence of NADPH-generating system | Homo sapiens | 1 | ALA3526048 | assay format | Scientific Literature | |
| 2. | ALA3541786 | ADME | Drug metabolism in supersomes expressing human recombinant CYP2C8 assessed as enzyme-mediated N-desmethylclozapine metabolite formation at 100 uM after 30 mins measured per nmol of P450 by HPLC analysis | Homo sapiens | 1 | ALA3525934 | single protein format | Scientific Literature | |
| 3. | ALA3538620 | ADME | Activity of human CYP2C8 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated 2-mercapto-3-(4-((6-methoxy-1-methyl-1H-benzo[d]imidazol-2-yl)methoxy)phenyl)propanamide formation at 20 uM after 2 hrs by radio-HPLC/LC-MS/MS analysis in presence of NADPH-generating system and NADPH-generating system/SAM | Homo sapiens | 1 | ALA3526048 | assay format | Scientific Literature | |
| 4. | ALA3539934 | ADME | Drug metabolism in supersomes expressing human recombinant CYP2C8 assessed as NADPH-fortified enzyme-mediated metabolite formation at 5 uM after 120 mins by radio HPLC analysis | Homo sapiens | 1 | ALA3526034 | single protein format | Scientific Literature | |
| 5. | ALA3539941 | ADME | Inhibition of CYP2C8 in human liver microsomes using rosiglitazone as substrate preincubated for 20 mins with substrate prior to initiation of reaction with NADPH by HPLC analysis | Homo sapiens | 1 | ALA3526034 | assay format | Scientific Literature | |
| 6. | ALA3541523 | ADME | Time dependent inhibition of CYP2C8 activity in human hepatocytes after 30 mins by liquid chromatography/tandem mass spectroscopy | Homo sapiens | 1 | ALA3526111 | cell-based format | Scientific Literature | |
| 7. | ALA3537742 | ADME | Drug metabolism assessed as recombinant CYP2C8 (unknown origin)-mediated 2-(5-chloro-4-(2-(2-chloro-4-cyclopropylphenylsulfonamido)-4-(1-hydroxy-2-methylpropan-2-ylcarbamoyl)phenoxy)-2-fluorophenyl)acetic acid formation at 10 uM after 30 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA3526017 | single protein format | Scientific Literature | |
| 8. | ALA3537747 | ADME | Drug metabolism assessed as recombinant CYP2C8 (unknown origin)-mediated compound formation treated with AMG 853 at 10 uM after 30 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA3526017 | single protein format | Scientific Literature | |
| 9. | ALA3537750 | ADME | Drug metabolism assessed as recombinant CYP2C8 (unknown origin)-mediated 2-(4-(4-(tert-butylcarbamoyl)-2-(2-chloro-4-(1-hydroxycyclopropyl)phenylsulfonamido)phenoxy)-5-chloro-2-fluorophenyl)acetic acid formation at 10 uM after 30 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA3526017 | single protein format | Scientific Literature | |
| 10. | ALA3540910 | ADME | Activity of human CYP2C8 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated 2-amino-3-((1-carboxy-2-(4-((6-methoxy-1-methyl-1H-benzo[d]imidazol-2-yl)methoxy)phenyl)ethyl)disulfanyl)propanoic acid formation at 20 uM after 2 hrs by radio-HPLC/LC-MS/MS analysis | Homo sapiens | 1 | ALA3526048 | assay format | Scientific Literature | |
| 11. | ALA3540914 | ADME | Activity of human CYP2C8 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated 5-(4-((6-methoxy-1H-benzo[d]imidazol-2-yl)methoxy)benzyl)thiazolidine-2,4-dione formation at 20 uM after 2 hrs by radio-HPLC/LC-MS/MS analysis in presence of NADPH-generating system and NADPH-generating system/SAM | Homo sapiens | 1 | ALA3526048 | assay format | Scientific Literature | |
| 12. | ALA3541541 | ADME | Activity of human CYP2C8 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated 3-(4-((6-methoxy-1-methyl-1H-benzo[d]imidazol-2-yl)methoxy)phenyl)-2-(methylthio)propanamide formation at 20 uM after 2 hrs by radio-HPLC/LC-MS/MS analysis in presence of NADPH-generating system/SAM | Homo sapiens | 1 | ALA3526048 | assay format | Scientific Literature | |
| 13. | ALA3541550 | ADME | Activity of human CYP2C8 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated 2-hydroxy-3-(4-((6-methoxy-1-methyl-1H-benzo[d]imidazol-2-yl)methoxy)phenyl)propanamide formation at 20 uM after 2 hrs by radio-HPLC/LC-MS/MS analysis in presence of NADPH-generating system and NADPH-generating system/SAM | Homo sapiens | 1 | ALA3526048 | assay format | Scientific Literature | |
| 14. | ALA3538128 | ADME | Drug metabolism in supersomes expressing human recombinant CYP2C8 assessed as enzyme-mediated N-desmethylclozapine metabolite formation at 10 uM after 30 mins measured per nmol of P450 by HPLC analysis | Homo sapiens | 1 | ALA3525934 | single protein format | Scientific Literature | |
| 15. | ALA3538704 | ADME | Activity of human CYP2C8 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated 5-hydroxy-5-(4-((6-methoxy-1-methyl-1H-benzo[d]imidazol-2-yl)methoxy)benzyl)thiazolidine-2,4-dione formation at 20 uM after 2 hrs by radio-HPLC/LC-MS/MS analysis in presence of NADPH-generating system and NADPH-generating system/SAM | Homo sapiens | 1 | ALA3526048 | assay format | Scientific Literature | |
| 16. | ALA3538713 | ADME | Activity of human CYP2C8 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated 3-(4-((6-methoxy-1-methyl-1H-benzo[d]imidazol-2-yl)methoxy)phenyl)-2-(methylthio)propanoic acid formation at 20 uM after 2 hrs by radio-HPLC/LC-MS/MS analysis in presence of NADPH-generating system/SAM and UDPGA/SAM | Homo sapiens | 1 | ALA3526048 | assay format | Scientific Literature | |
| 17. | ALA3539707 | ADME | Drug metabolism in supersomes expressing human recombinant CYP2C8 assessed as enzyme-mediated clozapine-N-oxide metabolite formation at 10 uM after 30 mins measured per nmol of P450 by HPLC analysis | Homo sapiens | 1 | ALA3525934 | single protein format | Scientific Literature | |
| 18. | ALA3539718 | ADME | Drug metabolism in supersomes expressing human recombinant CYP2C8 assessed as enzyme-mediated clozapine-N-oxide metabolite formation at 100 uM after 30 mins measured per nmol of P450 by HPLC analysis | Homo sapiens | 1 | ALA3525934 | single protein format | Scientific Literature | |
| 19. | ALA3540722 | ADME | Activity of human CYP2C8 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated 5-(4-((6-hydroxy-1-methyl-1H-benzo[d]imidazol-2-yl)methoxy)benzyl)thiazolidine-2,4-dione formation at 20 uM after 2 hrs by radio-HPLC/LC-MS/MS analysis in presence of NADPH-generating system and NADPH-generating system/SAM | Homo sapiens | 1 | ALA3526048 | assay format | Scientific Literature | |
| 20. | ALA3541009 | ADME | Activity of human CYP2C8 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated compound formation treated with [14C]-rivoglitazone at 20 uM after 2 hrs by radio-HPLC/LC-MS/MS analysis in presence of NADPH-generating system and NADPH-generating system/SAM | Homo sapiens | 5 | ALA3526048 | assay format | Scientific Literature |
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