# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3562071 | Functional | PubChem BioAssay. Selectivity Studies of mglur8 probe at mglur3. (Class of assay: confirmatory) | 1 | ALA1201862 | assay format | PubChem BioAssays | ||
2. | ALA3607017 | Binding | Negative allosteric modulation at mGlu3 receptor (unknown origin) at 10 uM | Homo sapiens | 1 | ALA3603801 | single protein format | Scientific Literature | |
3. | ALA3607070 | Binding | Positive allosteric modulation of mGlu3 receptor (unknown origin) | Homo sapiens | 1 | ALA3603827 | single protein format | Scientific Literature | |
4. | ALA3618569 | Functional | Agonist activity at wild type human recombinant mGlu3 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLIPR assay | Homo sapiens | 2 | ALA3616378 | cell-based format | Scientific Literature | |
5. | ALA3618570 | Functional | Agonist activity at wild type human recombinant mGlu3 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLIPR assay relative to glutamate | Homo sapiens | 2 | ALA3616378 | cell-based format | Scientific Literature | |
6. | ALA3618571 | Functional | Agonist activity at human recombinant mGlu3 receptor D279E mutant expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLIPR assay | Homo sapiens | 2 | ALA3616378 | cell-based format | Scientific Literature | |
7. | ALA3618572 | Functional | Agonist activity at human recombinant mGlu3 receptor D279E mutant expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLIPR assay relative to glutamate | Homo sapiens | 2 | ALA3616378 | cell-based format | Scientific Literature | |
8. | ALA3618573 | Functional | Agonist activity at human recombinant mGlu3 receptor Q306L mutant expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLIPR assay | Homo sapiens | 2 | ALA3616378 | cell-based format | Scientific Literature | |
9. | ALA3618574 | Functional | Agonist activity at human recombinant mGlu3 receptor Q306L mutant expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLIPR assay relative to glutamate | Homo sapiens | 2 | ALA3616378 | cell-based format | Scientific Literature | |
10. | ALA3618575 | Functional | Agonist activity at human recombinant mGlu3 receptor D279E and Q306L mutant expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLIPR assay | Homo sapiens | 2 | ALA3616378 | cell-based format | Scientific Literature | |
11. | ALA3618576 | Functional | Agonist activity at human recombinant mGlu3 receptor Q306L and Q306L mutant expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLIPR assay relative to glutamate | Homo sapiens | 2 | ALA3616378 | cell-based format | Scientific Literature | |
12. | ALA3619270 | Binding | Displacement of [3H]-459477 from human recombinant mGlu3 receptor expressed in AV12 cells after 90 mins by liquid scintillation counting | Homo sapiens | 17 | ALA3616378 | cell-based format | Scientific Literature | |
13. | ALA3619410 | Functional | Agonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 hr by fluorescence assay | Homo sapiens | 17 | ALA3616378 | cell-based format | Scientific Literature | |
14. | ALA3619411 | Functional | Agonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 hr by fluorescence assay relative to glutamate | Homo sapiens | 15 | ALA3616378 | cell-based format | Scientific Literature | |
15. | ALA3619412 | Functional | Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as reversal of DCG-4-inhibited, forskolin-stimulated cAMP production after 1 hr by fluorescence assay | Homo sapiens | 8 | ALA3616378 | cell-based format | Scientific Literature | |
16. | ALA3619413 | Functional | Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as reversal of DCG-4-inhibited, forskolin-stimulated cAMP production after 1 hr by fluorescence assay relative to control | Homo sapiens | 8 | ALA3616378 | cell-based format | Scientific Literature | |
17. | ALA3619414 | Functional | Agonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1.5 hrs by FLIPR assay | Homo sapiens | 17 | ALA3616378 | cell-based format | Scientific Literature | |
18. | ALA3619415 | Functional | Agonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1.5 hrs by FLIPR assay relative to glutamate | Homo sapiens | 3 | ALA3616378 | cell-based format | Scientific Literature | |
19. | ALA3619416 | Functional | Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as inhibition of glutamate-stimulated Ca2+ mobilization after 1.5 hrs by FLIPR assay | Homo sapiens | 14 | ALA3616378 | cell-based format | Scientific Literature | |
20. | ALA3619417 | Functional | Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as inhibition of glutamate-stimulated Ca2+ mobilization after 1.5 hrs by FLIPR assay relative to control | Homo sapiens | 14 | ALA3616378 | cell-based format | Scientific Literature |