Antiviral activity against woodchuck hepatitis virus chronically infected orally dosed woodchucks assessed as reduction in serum viremia administered once daily for 4 weeks
Antiviral activity against woodchuck hepatitis virus chronically infected woodchucks assessed as reduction of serum viral DNA at 1 mg/kg/day, po after 4 weeks
Antiviral activity against woodchuck hepatitis virus chronically infected woodchucks assessed as log reduction of serum viral DNA at 3 mg/kg/day, po after 4 weeks
Antiviral activity against woodchuck hepatitis virus chronically infected woodchucks assessed as log reduction of serum viral DNA at 10 mg/kg/day, po after 4 weeks
Antiviral activity against woodchuck hepatitis virus chronically infected woodchucks assessed as log reduction of serum viral DNA at 30 mg/kg/day, po after 4 weeks
Antiviral activity against woodchuck hepatitis virus chronically infected in woodchucks assessed as reduction in viral surface antigen level in blood at 30 mg/kg/day, po after 4 weeks
Antiviral activity against woodchuck hepatitis virus chronically infected in woodchucks assessed as reduction in anti-WHV core antigen antibody levels at 30 mg/kg/day, po after 4 weeks
Antiviral activity against woodchuck hepatitis virus chronically infected in woodchucks M7236 assessed as reduction in anti-WHs antibody levels at 30 mg/kg/day, po after 4 weeks
Antiviral activity against woodchuck hepatitis virus chronically infected in woodchucks M7250 assessed as reduction in anti-WHs antibody levels at 30 mg/kg/day, po after 4 weeks
Antiviral activity against woodchuck hepatitis virus chronically infected woodchucks assessed as reduction of viral DNA replicative intermediates at 1 mg/kg/day, po after 4 weeks
Antiviral activity against woodchuck hepatitis virus chronically infected woodchucks assessed as reduction of viral DNA replicative intermediates at 3 mg/kg/day, po after 4 weeks
Antiviral activity against woodchuck hepatitis virus chronically infected woodchucks assessed as reduction of viral DNA replicative intermediates at 10 mg/kg/day, po after 4 weeks
Antiviral activity against woodchuck hepatitis virus chronically infected woodchucks assessed as log reduction of viral DNA replicative intermediates at 30 mg/kg/day, po after 4 weeks relative to control
Antiviral activity against Woodchuck hepatitis virus infected in woodchuck assessed as reduction of viral DNA replicative intermediate level per ug of total cell DNA at 15 mg/kg, po qd measured on 36th week on 48 weeks study (Rvb = 1132 +/- 738 pg)
Antiviral activity against Woodchuck hepatitis virus infected in woodchuck assessed as reduction of viral DNA replicative intermediate level per ug of total cell DNA at 15 mg/kg, po qd measured on 12th week on 48 weeks study (Rvb = 1495 +/- 890 pg)
Antiviral activity against Woodchuck hepatitis virus infected in woodchuck assessed as frequency of hepatocytes expressing viral antigen at 15 mg/kg, po qd measured on 12th week on 48 weeks study
Antiviral activity against Woodchuck hepatitis virus infected in woodchuck assessed as frequency of hepatocytes expressing viral antigen at 15 mg/kg, po qd for 48 weeks measured on 60th week
Antiviral activity against Woodchuck hepatitis virus infected in woodchuck assessed as absent of lesion in portal hepatitis at 15 mg/kg, po qd measured on 12th week on 48 weeks study