Biodistribution in 15 mg/kg unlabeled 6,7-dimethoxy-2-(3-(5-methoxy-3,4-dihydronaphthalen-1(2H)-ylidene)propyl)-1,2,3,4-tetrahydroisoquinoline pretreated Wistar rat duodenum at 13+/-2 MBq, iv after 80 mins
Drug uptake in fasted intralipid-challenged Sprague-Dawley rat duodenum at 5 mg/kg, po administered 30 mins prior to intralipid-challenge measured at 2 hrs by LC/MS analysis
Drug uptake in fasted intralipid-challenged Sprague-Dawley rat duodenum at 5 mg/kg, po administered 30 mins prior to intralipid-challenge measured at 6 hrs by LC/MS analysis
Drug uptake in fasted intralipid-challenged Sprague-Dawley rat duodenum at 5 mg/kg, po administered 30 mins prior to intralipid-challenge measured at 17 hrs by LC/MS analysis
Efflux Rattus norvegicus (rat)io of apparent permeability from basal to apical side over apical to basal side of Sprague-Dawley Rattus norvegicus (rat) duodenum sac at 1 mg/ml by HPLC method in presence of 250 uM P-gp/MRP2 inhibitor, verampil
Efflux Rattus norvegicus (rat)io of apparent permeability from basal to apical side over apical to basal side of Sprague-Dawley Rattus norvegicus (rat) duodenum sac at 500 ug/ml by HPLC method in presence of 250 uM P-gp/MRP2 inhibitor, verampil
Apparent permeability across basal to apical side of Sprague-Dawley Rattus norvegicus (rat) everted duodenum sac at 1 mg/ml by HPLC method in presence of 250 uM P-gp/MRP2 inhibitor, verampil
Apparent permeability across basal to apical side of Sprague-Dawley Rattus norvegicus (rat) everted duodenum sac at 500 ug/ml by HPLC method in presence of 250 uM P-gp/MRP2 inhibitor, verampil
Apparent permeability across apical to basal side of Sprague-Dawley Rattus norvegicus (rat) normal duodenum sac at 1 mg/ml by HPLC method in presence of 250 uM P-gp/MRP2 inhibitor, verampil
Apparent permeability across apical to basal side of Sprague-Dawley Rattus norvegicus (rat) normal duodenum sac at 500 ug/ml by HPLC method in presence of 250 uM P-gp/MRP2 inhibitor, verampil
Efflux Rattus norvegicus (rat)io of apparent permeability from basal to apical side over apical to basal side of Sprague-Dawley Rattus norvegicus (rat) duodenum sac at 1 mg/ml by HPLC method
Efflux Rattus norvegicus (rat)io of apparent permeability from basal to apical side over apical to basal side of Sprague-Dawley Rattus norvegicus (rat) duodenum sac at 500 ug/ml by HPLC method