# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1027010 | B | Enhancement of bile salt export pump promoter transactivation | 1 | single protein format | Scientific Literature | |||
2. | ALA1743159 | A | Substrates of transporters of clinical importance in the absorption and disposition of drugs, BSEP | Homo sapiens | 2 | single protein format | Scientific Literature | ||
3. | ALA1743178 | A | Inhibitors of transporters of clinical importance in the absorption and disposition of drugs, BSEP | Homo sapiens | 3 | single protein format | Scientific Literature | ||
4. | ALA1959691 | B | Inhibition of BSEP | 1 | single protein format | Scientific Literature | |||
5. | ALA2020808 | B | Restoration of wild type human BSEP trafficking to cell membrane in MDCK2 cells co-expressing NTCP assessed as decrease in [3H]taurocholate accumulation at 10 to 100 uM preincubated for 24 hrs prior incubation with [3H]taurocholate measured after 2 hrs by liquid scintillation counting | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
6. | ALA2020809 | B | Restoration of human BSEP E297G mutant trafficking to cell membrane in MDCK2 cells co-expressing NTCP assessed as accumulation of [3H]taurocholate at 100 uM preincubated for 24 hrs prior incubation with [3H]taurocholate measured after 2 hrs by liquid scintillation counting | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
7. | ALA2020810 | B | Restoration of human BSEP E297G mutant trafficking to cell membrane in MDCK2 cells co-expressing NTCP assessed as accumulation of [3H]taurocholate at 10 uM preincubated for 24 hrs prior incubation with [3H]taurocholate measured after 2 hrs by liquid scintillation counting | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
8. | ALA2020811 | B | Restoration of human BSEP E297G mutant trafficking to cell membrane in MDCK2 cells co-expressing NTCP assessed as decrease in [3H]taurocholate accumulation preincubated for 24 hrs prior incubation with [3H]taurocholate measured after 2 hrs by liquid scintillation counting | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
9. | ALA2020885 | B | Restoration of human BSEP E297G mutant trafficking to cell membrane in MDCK2 cells co-expressing NTCP assessed as increase in [3H]taurocholate transport measuring apparent efflux clearance across the apical membrane at 1 mM preincubated for 24 hrs prior incubation with [3H]taurocholate measured after 2 hrs by transcellular transport assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA2020886 | B | Restoration of human BSEP E297G mutant trafficking to cell membrane in MDCK2 cells co-expressing NTCP assessed as increase in [3H]taurocholate transport measuring apparent efflux clearance across the apical membrane at 10 uM preincubated for 24 hrs prior incubation with [3H]taurocholate measured after 2 hrs by transcellular transport assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
11. | ALA2034292 | B | Enhancement of human BSEP E297G mutant trafficking to cell membrane in MDCK2 cells co-expressing NTCP assessed as accumulation of [3H]taurocholate at 10 uM preincubated for 24 hrs prior incubation with [3H]taurocholate measured after 2 hrs by liquid scintillation counting | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
12. | ALA2034296 | B | Enhancement of human BSEP E297G mutant trafficking to cell membrane in MDCK2 cells co-expressing NTCP assessed as accumulation of [3H]taurocholate at 1 uM preincubated for 24 hrs prior incubation with [3H]taurocholate measured after 2 hrs by liquid scintillation counting | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
13. | ALA2077352 | F | TP_TRANSPORTER: competitive inhibition of Taurocholate uptake in membrane vesicles prepared from High Five cells infected with the ABCB11 baculovirus | 3 | cell membrane format | TP-search Transporter Database | |||
14. | ALA2077353 | F | TP_TRANSPORTER: Western in vitro, primary human hepatocyte | Homo sapiens | 2 | cell-based format | TP-search Transporter Database | ||
15. | ALA2075387 | F | TP_TRANSPORTER: uptake in membrane vesicles isolated from Bsep-expressing Sf9 cells | 2 | cell membrane format | TP-search Transporter Database | |||
16. | ALA2075450 | F | TP_TRANSPORTER: uptake in membrane vesicles prepared from High Five cells infected with the ABCB11 baculovirus | 1 | cell membrane format | TP-search Transporter Database | |||
17. | ALA2075451 | F | TP_TRANSPORTER: uptake in membrane vesicles isolated from Bsep-expressing Sf9 cells | 1 | cell membrane format | TP-search Transporter Database | |||
18. | ALA2075452 | F | TP_TRANSPORTER: inhibition of Taurocholate uptake(Rifampicin SV 30uM, 50 % of control) in membrane vesicles prepared from High Five cells infected with the ABCB11 baculovirus | 1 | cell membrane format | TP-search Transporter Database | |||
19. | ALA2075453 | F | TP_TRANSPORTER: inhibition of Taurocholate uptake(Glibenclamide 30uM, 50 % of control) in membrane vesicles prepared from High Five cells infected with the ABCB11 baculovirus | 1 | cell membrane format | TP-search Transporter Database | |||
20. | ALA2075454 | F | TP_TRANSPORTER: inhibition of Taurochenodeoxycholate uptake(CsA 30uM, 30 % of control) in membrane vesicles prepared from High Five cells infected with the ABCB11 baculovirus | 1 | cell membrane format | TP-search Transporter Database |