# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3579954 | Binding | Inhibition of human placental HexB using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometry | Homo sapiens | 2 | ALA3576868 | assay format | Scientific Literature | |
2. | ALA3579968 | Binding | Inhibition of human placental HexB using MUGS substrate incubated for 1 to 2 hrs at pH 7.0 by spectrofluorometry | Homo sapiens | 2 | ALA3576868 | assay format | Scientific Literature | |
3. | ALA1250605 | Binding | Inhibition of human placental lysosomal hexosaminidase B at 5 uM | Homo sapiens | 3 | ALA1250539 | assay format | Scientific Literature | |
4. | ALA4355748 | Binding | Inhibition of human beta hexosaminidase assessed as inhibitory constant using 4-methylumbelliferyl 2-acetamido-2-deoxy-beta-D-glucopyranoside as substrate incubated for 30 mins by fluorescence spectrophotometry | Homo sapiens | 1 | ALA4354805 | single protein format | Scientific Literature | |
5. | ALA4355756 | Binding | Inhibition of human beta hexosaminidase assessed as inhibitory constant using 4-methylumbelliferyl N-acetyl-beta-D-glucosaminide dihydrate as substrate measured every 60 sec for 45 mins by fluorescence spectrophotometry | Homo sapiens | 41 | ALA4354805 | single protein format | Scientific Literature | |
6. | ALA986741 | Binding | Increase in thermostability of beta Hex A betaR505Q mutant isolated from Sandhoff disease patient assessed as residual enzyme activity at 3 ug/ml at 37 degC after 30 mins relative to control | Homo sapiens | 1 | ALA1156436 | single protein format | Scientific Literature | |
7. | ALA986742 | Binding | Pharmacological chaperone effect on beta Hex A beta-C137Y/C137Y mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity at 3 ug/ml by immunoselection assay relative to control | Homo sapiens | 1 | ALA1156436 | single protein format | Scientific Literature | |
8. | ALA986743 | Binding | Pharmacological chaperone effect on beta Hex A beta-C137Y/C137Y mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity at 300 mg/ml by immunoselection assay relative to control | Homo sapiens | 1 | ALA1156436 | single protein format | Scientific Literature | |
9. | ALA986744 | Binding | Pharmacological chaperone effect on beta Hex A beta-C137Y/C137Y mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX S activity at 3 ug/ml by immunoselection assay relative to control | Homo sapiens | 1 | ALA1156436 | single protein format | Scientific Literature | |
10. | ALA986745 | Binding | Pharmacological chaperone effect on beta Hex A beta-C137Y/C137Y mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX S activity at 300 mg/ml by immunoselection assay relative to control | Homo sapiens | 1 | ALA1156436 | single protein format | Scientific Literature | |
11. | ALA986746 | Binding | Pharmacological chaperone effect on beta Hex A beta-T150P/P417L mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity at 3 ug/ml by immunoselection assay relative to control | Homo sapiens | 1 | ALA1156436 | single protein format | Scientific Literature | |
12. | ALA986747 | Binding | Pharmacological chaperone effect on beta Hex A beta-T150P/P417L mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity at 300 mg/ml by immunoselection assay relative to control | Homo sapiens | 1 | ALA1156436 | single protein format | Scientific Literature | |
13. | ALA986748 | Binding | Pharmacological chaperone effect on beta Hex A beta-T150P/P417L mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX S activity at 3 ug/ml by immunoselection assay relative to control | Homo sapiens | 1 | ALA1156436 | single protein format | Scientific Literature | |
14. | ALA986749 | Binding | Pharmacological chaperone effect on beta Hex A beta-T150P/P417L mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX S activity at 300 mg/ml by immunoselection assay relative to control | Homo sapiens | 1 | ALA1156436 | single protein format | Scientific Literature | |
15. | ALA986754 | Binding | Pharmacological chaperone effect on beta Hex A beta-P417L/delta16kb mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity at 3 ug/ml by immunoselection assay relative to control | Homo sapiens | 1 | ALA1156436 | single protein format | Scientific Literature | |
16. | ALA983111 | Binding | Pharmacological chaperone effect on beta Hex A beta-P417L/delta16kb mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity at 300 mg/ml by immunoselection assay relative to control | Homo sapiens | 1 | ALA1156436 | single protein format | Scientific Literature | |
17. | ALA983112 | Binding | Pharmacological chaperone effect on beta Hex A beta-P417L/delta16kb mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX S activity at 3 ug/ml by immunoselection assay relative to control | Homo sapiens | 1 | ALA1156436 | single protein format | Scientific Literature | |
18. | ALA983113 | Binding | Pharmacological chaperone effect on beta Hex A beta-P417L/delta16kb mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX S activity at 300 mg/ml by immunoselection assay relative to control | Homo sapiens | 1 | ALA1156436 | single protein format | Scientific Literature | |
19. | ALA983118 | Binding | Pharmacological chaperone effect on beta Hex A beta-P504S/delta16kb mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity at 3 ug/ml by immunoselection assay relative to control | Homo sapiens | 1 | ALA1156436 | single protein format | Scientific Literature | |
20. | ALA983119 | Binding | Pharmacological chaperone effect on beta Hex A beta-P504S/delta16kb mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity at 300 mg/ml by immunoselection assay relative to control | Homo sapiens | 1 | ALA1156436 | single protein format | Scientific Literature |