| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA930241 | B | Binding affinity to IL2 assessed as inhibition of IL2-IL2Ralpha interaction | 1 | ALA1142223 | single protein format | Scientific Literature | ||
| 2. | ALA3077408 | B | Binding affinity to IL2 (unknown origin) assessed as inhibition of binding to IL2 receptor alpha | Homo sapiens | 2 | ALA3046838 | single protein format | Scientific Literature | |
| 3. | ALA3291700 | B | Binding affinity to IL-2 (unknown origin) | Homo sapiens | 8 | ALA3286146 | single protein format | Scientific Literature | |
| 4. | ALA3705951 | B | Inhibition Assay: Jurkat cells were placed in a 96 well plate (0.5 million cells per well in 1% FBS medium) then a test compound of this invention was added at different concentrations. After 10 minutes, the cells were activated with PHA (final concentration 2.5 μg/mL) and incubated for 20 hours at 37° C. under CO2. The final volume was 200 μL. Following incubation, the cells were centrifuged and the supernatants collected and stored at −70° C. prior to assaying for IL-2 production. A commercial ELISA kit (IL-2 Eli-pair, Diaclone Research, Besancon, France) was used to detect production of IL-2, from which dose response curves were obtained. | 9 | ALA3638624 | cell-based format | BindingDB Database | ||
| 5. | ALA4013731 | B | Binding affinity to recombinant human IL-2 by SPR assay | Homo sapiens | 17 | ALA4011646 | single protein format | Scientific Literature | |
| 6. | ALA4425349 | B | Binding affinity to human IL-2 measured over 30 mins by fluorescence polarization assay | Homo sapiens | 1 | ALA4425089 | single protein format | Scientific Literature | |
| 7. | ALA4822548 | B | Inhibition of IL2-induced STAT3 phosphorylation in human NK92 cells incubated for 30 mins followed by IL-15 stimulation and measured after 1 hr by alphascreen assay | Homo sapiens | 25 | ALA4819118 | cell-based format | Scientific Literature | |
| 8. | ALA4834052 | B | Binding affinity to L19-IL2 (unknown origin) by fluorescence polarization assay | Homo sapiens | 22 | ALA4831555 | single protein format | Scientific Literature | |
| 9. | ALA4834057 | B | Binding affinity to IL2 (unknown origin) preincubated for 15 mins followed by NARA1 addition and measured after 1 hr in presence of NARA1 by ELISA | Homo sapiens | 1 | ALA4831555 | single protein format | Scientific Literature | |
| 10. | ALA4834058 | B | Binding affinity to IL2 (unknown origin) by SPR assay | Homo sapiens | 2 | ALA4831555 | single protein format | Scientific Literature | |
| 11. | ALA4834060 | B | Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs by ELISA | Homo sapiens | 24 | ALA4831556 | cell-based format | Scientific Literature | |
| 12. | ALA4834061 | B | Inhibition of PHA-stimulated IL2 secretion in human Jurkat cells at 1 uM preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs by ELISA relative to control | Homo sapiens | 6 | ALA4831556 | cell-based format | Scientific Literature | |
| 13. | ALA4834178 | B | Inhibition of IL2 in thapsigargin stimulated human whole blood at 80 mg qd after 1 day (Rvb = 15%) | Homo sapiens | 1 | ALA4831556 | tissue-based format | Scientific Literature | |
| 14. | ALA4834179 | B | Inhibition of IL2 in thapsigargin stimulated human whole blood at 80 mg qd after 14 days (Rvb = 8%) | Homo sapiens | 1 | ALA4831556 | tissue-based format | Scientific Literature | |
| 15. | ALA4834182 | B | Inhibition of IL2 in thapsigargin stimulated human whole blood at 160 mg qd after 1 day (Rvb = 15%) | Homo sapiens | 1 | ALA4831556 | tissue-based format | Scientific Literature | |
| 16. | ALA4834183 | B | Inhibition of IL2 in thapsigargin stimulated human whole blood at 160 mg qd after 14 days (Rvb = 8%) | Homo sapiens | 1 | ALA4831556 | tissue-based format | Scientific Literature | |
| 17. | ALA4834186 | B | Inhibition of IL2 in thapsigargin stimulated human whole blood at 80 mg bid after 1 day (Rvb = 15%) | Homo sapiens | 1 | ALA4831556 | tissue-based format | Scientific Literature | |
| 18. | ALA4834187 | B | Inhibition of IL2 in thapsigargin stimulated human whole blood at 80 mg bid after 14 days (Rvb = 8%) | Homo sapiens | 1 | ALA4831556 | tissue-based format | Scientific Literature | |
| 19. | ALA4834190 | B | Inhibition of IL2 in thapsigargin stimulated human whole blood | Homo sapiens | 1 | ALA4831556 | tissue-based format | Scientific Literature | |
| 20. | ALA5029731 | B | Induction of stability of human recombinant interleukin 2 assessed as binding affinity of drug-conjugated rIL2 to human TTR in PBS buffer at pH 7.4 measured after 20 mins fluorescence polarization assay | Homo sapiens | 1 | ALA5029163 | single protein format | Scientific Literature |
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