# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1040546 | B | Inhibition of mitochondrial malate dehydrogenase assessed as residual enzyme activity at 10 uM by spectrophotometry | 27 | ALA1154701 | single protein format | Scientific Literature | ||
2. | ALA1041437 | B | Inhibition of mitochondrial malate dehydrogenase by spectrophotometry | 19 | ALA1154701 | single protein format | Scientific Literature | ||
3. | ALA2384176 | B | Inhibition of human recombinant carboxy-terminal his-tagged MDH-2 (20 to 338) expressed in Escherichia coli using oxaloacetic acid as substrate after 10 mins by UV endpoint analysis | Homo sapiens | 2 | ALA2380202 | assay format | Scientific Literature | |
4. | ALA3280959 | B | Inhibition of malate dehydrogenase (unknown origin) by spectrophotometry | Homo sapiens | 13 | ALA3271955 | single protein format | Scientific Literature | |
5. | ALA3374591 | B | Binding affinity to MDH2 in human HCT116 cells using alexa 488 tagged compound by photo-affinity conjugation and 2D PAGE method | Homo sapiens | 1 | ALA3351237 | cell-based format | Scientific Literature | |
6. | ALA3374593 | B | Inhibition of MDH2 (unknown origin) pre-incubated for 1 hr followed by malate and NAD+ addition | Homo sapiens | 9 | ALA3351237 | single protein format | Scientific Literature | |
7. | ALA3374594 | B | Binding affinity to human recombinant MDH2 at 10 uM under UV irradiation by SDS-PAGE based photo-affinity labeling method | Homo sapiens | 6 | ALA3351237 | single protein format | Scientific Literature | |
8. | ALA3374597 | B | Inhibition of MDH2 in human HCT116 cells assessed as AMPK activation at 10 uM by immunoblot assay | Homo sapiens | 2 | ALA3351237 | cell-based format | Scientific Literature | |
9. | ALA3374598 | B | Inhibition of MDH2 in human HCT116 cells assessed as reduction in ACC phosphorylation at 10 uM by immunoblot assay | Homo sapiens | 2 | ALA3351237 | cell-based format | Scientific Literature | |
10. | ALA3374599 | B | Competitive inhibition of MDH2 (unknown origin) using varying NADH level by oxaloacetate-dependent NADH oxidation based Lineweaver-Burk plot | Homo sapiens | 2 | ALA3351237 | single protein format | Scientific Literature | |
11. | ALA3370225 | B | Inhibition of human recombinant carboxy-terminal His-tagged MDH-2 | Homo sapiens | 1 | ALA3352775 | single protein format | Scientific Literature | |
12. | ALA3583867 | B | Inhibition of malate dehydrogenase 2 (unknown origin) | Homo sapiens | 34 | ALA3580578 | single protein format | Scientific Literature | |
13. | ALA4031660 | B | Inhibition of human MDH2 after 30 mins by oxaloacetate-dependent NADH oxidation assay | Homo sapiens | 30 | ALA4028871 | single protein format | Scientific Literature | |
14. | ALA4031662 | B | Inhibition of MDH2 in human HCT116 cells assessed as increase in intracellular oxygen content at 10 uM after 6 hrs under hypoxic condition by mono azo rhodamine fluorescent probe based fluorescence method | Homo sapiens | 4 | ALA4028871 | cell-based format | Scientific Literature | |
15. | ALA4031667 | B | Inhibition of MDH2 in human HCT116 cells assessed as inhibition of mitochondrial respiration by measuring reduction in oxygen consumption rate at 5 uM in presence of oligomycin, FCCP and rotenone using XF24 extracellular flux analyzer | Homo sapiens | 1 | ALA4028871 | cell-based format | Scientific Literature | |
16. | ALA4031669 | B | Inhibition of MDH2 in human HCT116 cells assessed as inhibition of mitochondrial respiration by measuring phosphorylation of AMPK up to 10 uM by immunoblot method | Homo sapiens | 1 | ALA4028871 | cell-based format | Scientific Literature | |
17. | ALA4031670 | B | Inhibition of MDH2 in human HCT116 cells assessed as inhibition of mitochondrial respiration by measuring ACC inactivation up to 10 uM by immunoblot method | Homo sapiens | 1 | ALA4028871 | cell-based format | Scientific Literature | |
18. | ALA4031671 | B | Inhibition of MDH2 in human HCT116 cells assessed as inhibition of mitochondrial respiration by measuring reduction in intracellular ATP level up to 10 uM by immunoblot method | Homo sapiens | 1 | ALA4028871 | cell-based format | Scientific Literature | |
19. | ALA4031682 | B | Inhibition of MDH2 (unknown origin) | Homo sapiens | 2 | ALA4028871 | single protein format | Scientific Literature | |
20. | ALA4031688 | B | Competitive inhibition of human MDH2 using oxaloacetic acid as substrate in presence of NADH after 30 mins by double reciprocal plot analysis | Homo sapiens | 1 | ALA4028871 | single protein format | Scientific Literature |