Antagonist activity against rat P2X3 receptor expressed in Xenopus laevis oocyte assessed as inhibition of alpha, beta-meATP-induced inward current by two-electrode voltage-clamp electrophysiology
Agonist activity at rat P2X3 receptor expressed in HEK cells assessed as induction of inward current at 100 uM by patch clamp method relative to alpha, beta-meATP
Activity at rat P2X3 receptor expressed in HEK cells assessed as depression of amplitude current subsequent response to alpha, beta-meATP by patch clamp method relative to control
Antagonist activity at rat P2X3 receptor expressed in HEK cells assessed as inhibition of alpha, beta-meATP-induced inward current at 100 uM by patch clamp method
Agonist activity at rat P2X3 receptor expressed in HEK cells assessed as induction of alpha, beta-meATP inward current at 100 uM pretreated before alpha, beta-meATP induction by patch clamp method
Antagonist activity at rat recombinant P2X3 receptor expressed in HEK293T cells assessed as desensitization of alpha,beta-methyleneATP-induced current at 100 uM after 20 secs by patch clamp technique
Antagonist activity at rat recombinant P2X3 receptor expressed in HEK293T cells assessed as desensitization of alpha,beta-methyleneATP-induced current after 20 secs by patch clamp technique
Antagonist activity at rat recombinant P2X3 receptor expressed in HEK293T cells assessed as desensitization of alpha,beta-methyleneATP-induced current at 0.3 uM after 20 secs by patch clamp technique