| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA904749 | B | Inhibition of human recombinant UGT2B4 at 25 uM by fluorescence spectroscopy | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 2. | ALA1908092 | A | Specific activity of expressed human recombinant UGT2B4 | Homo sapiens | 78 | single protein format | Scientific Literature | ||
| 3. | ALA1743333 | A | Substrate of human UDP-glucuronosyltransferase UGT2B4 | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 4. | ALA3541117 | A | Activity of human UGT2B4 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated (2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(5-(4-((6-methoxy-1-methyl-1H-benzo[d]imidazol-2-yl)methoxy)benzyl)-2,4-dioxothiazolidin-3-yl)tetrahydro-2H-pyran-2-carboxylic acid formation at 20 uM after 4 hrs by radio-HPLC/LC-MS/MS analysis in presence of UDPGA | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 5. | ALA3539913 | A | Drug metabolism assessed as recombinant human UGT2B4 assessed as O-glucuronidation at 100 uM incubated for 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 6. | ALA3539924 | A | Drug metabolism assessed as recombinant human UGT2B4 assessed as N-glucuronidation at 100 uM incubated for 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA3540238 | A | Drug metabolism assessed as human recombinant UGT2B4-mediated (2S,3S,4S,5R,6S)-6-(2-(4-(4-(tert-butylcarbamoyl)-2-(2-chloro-4-cyclopropylphenylsulfonamido)phenoxy)-5-chloro-2-fluorophenyl)acetoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid formation at 10 uM after 30 mins by LC-MS/MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 8. | ALA3539948 | A | Drug metabolism assessed as recombinant human C-terminal His-tagged UGT2B4-mediated estradiol-17-glucuronide formation at 200 uM after 15 to 60 mins by HPLC analysis in presence of UDPGA | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA3539950 | A | Drug metabolism assessed as recombinant human C-terminal His-tagged UGT2B4-mediated 13-epiestradiol-17-glucuronide formation at 200 uM after 15 to 60 mins by HPLC analysis in presence of UDPGA | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA3541850 | A | Drug metabolism assessed as UDPGA-fortified human recombinant UGT2B4-mediated DTG glucuronide metabolite ((2S,3S,4S,5R,6S)-6-((4R,12aS)-9-(2,4-difluorobenzylcarbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazin-7-yloxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid) formation at 16 uM after 120 mins by radio-HPLC analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA3538221 | A | Drug metabolism assessed as recombinat UGT2B4 (unknown origin) -mediated dextrophan-O-glucuronide formation | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA3538808 | A | Drug metabolism assessed as human UGT2B4-mediated N-glucuronide-triclocarban formation expressed in baculovirus infected insect sf9 cells incubated for 5 mins prior to UDPGA addition measured after 5 to 30 mins by LC-UV analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA3540511 | A | Drug metabolism in human KB3 cells overexpressing human UGT2B4 assessed as enzyme-mediated metabolites formation at 30 uM for 24 to 72 hrs by HPLC analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA3541744 | A | Activity of human recombinant UGT2B4 expressed in insect cells assessed as enzyme mediated glucuronidation at 500 uM by LC-MS/MS method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA3541759 | A | Drug metabolism assessed as human UGT2B4-mediated N'-glucuronide-triclocarban formation expressed in baculovirus infected insect sf9 cells incubated for 5 mins prior to UDPGA addition measured after 5 to 30 mins by LC-UV analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA3534356 | A | Activity of human recombinant UGT2B4 expressed in baculovirus-infected insect cells assessed as enzyme-mediated glucuronidation per mg of protein after 10 mins in presence of UDPGA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA3532621 | A | Drug metabolism assessed as recombinant human C-terminal His-tagged UGT2B4-mediated estriol-16-glucuronide formation after 15 to 60 mins by Michaelis-Menten equation analysis in presence of UDPGA | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 18. | ALA3532976 | A | Drug metabolism assessed as recombinant human C-terminal His-tagged UGT2B4-mediated 16-epiestriol-16-glucuronide formation after 15 to 60 mins by Michaelis-Menten equation analysis in presence of UDPGA | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 19. | ALA3532984 | A | Drug metabolism assessed as recombinant human C-terminal His-tagged UGT2B4-mediated 17-epiestriol-17-glucuronide formation at 200 uM after 15 to 60 mins by HPLC analysis in presence of UDPGA | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 20. | ALA3534075 | A | Drug metabolism assessed as human UGT2B4-mediated glucuronidation expressed in baculovirus infected insect sf9 cells incubated for 5 mins prior to UDPGA addition measured after 5 to 30 mins by LC-UV analysis | Homo sapiens | 3 | cell-based format | Scientific Literature |
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