| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA921546 | B | Inhibition of Pseudomonas aeruginosa LasR | Pseudomonas aeruginosa | 8 | single protein format | Scientific Literature | ||
| 2. | ALA1049320 | B | Inhibition of Pseudomonas aeruginosa LasR | Pseudomonas aeruginosa | 5 | single protein format | Scientific Literature | ||
| 3. | ALA1776226 | B | Induction of lasR-mediated quorum sensing in Pseudomonas aeruginosa PAKR02 harboring lasB::luxCDABE gene assessed as lasR-induction ratio at 10'-4 M after 24 hrs by bioluminescence assay relative to control | Pseudomonas aeruginosa | 37 | single protein format | Scientific Literature | ||
| 4. | ALA1776227 | B | Inhibition of OdDHL-induced LasR activation in Pseudomonas aeruginosa PAKR02 harboring lasB::luxCDABE gene assessed as remaining Las activity at 10'-4 M after 24 hrs by bioluminescence assay | Pseudomonas aeruginosa | 37 | single protein format | Scientific Literature | ||
| 5. | ALA1815983 | F | Antagonist activity at Pseudomonas aeruginosa PAO1 MW1 (pUM15) LasR assessed as inhibition of OdDHL-induced quorum sensing activation at 10 uM after 8 hrs by beta-galactosidase reporter gene assay relative to untreated control | Pseudomonas aeruginosa PAO1 | 21 | assay format | Scientific Literature | ||
| 6. | ALA1816007 | F | Agonist activity at Pseudomonas aeruginosa PAO1 MW1 (pUM15) LasR at 10 uM after 8 hrs by beta-galactosidase reporter gene assay relative to OdDHL | Pseudomonas aeruginosa PAO1 | 21 | assay format | Scientific Literature | ||
| 7. | ALA1816012 | F | Antagonist activity at Pseudomonas aeruginosa PAO1 MW1 (pUM15) LasR assessed as inhibition of OdDHL-induced quorum sensing activation after 8 hrs by beta-galactosidase reporter gene assay | Pseudomonas aeruginosa PAO1 | 1 | assay format | Scientific Literature | ||
| 8. | ALA1816064 | F | Agonist activity at Pseudomonas aeruginosa PAO1 MW1 (pUM15) LasR after 8 hrs by beta-galactosidase reporter gene assay relative to OdDHL | Pseudomonas aeruginosa PAO1 | 3 | assay format | Scientific Literature | ||
| 9. | ALA1816110 | F | Antagonist activity at Pseudomonas aeruginosa PAO1 MW1 (pUM15) LasR assessed as inhibition of N-(3-oxo)-dodecanoyl HL-induced quorum sensing activation at 10 uM relative to untreated control | Pseudomonas aeruginosa PAO1 | 32 | assay format | Scientific Literature | ||
| 10. | ALA1816166 | F | Agonist activity at Pseudomonas aeruginosa PAO1 MW1 (pUM15) LasR assessed as activation of quorum sensing at 10 uM relative to N-(3-oxo)-dodecanoyl HL | Pseudomonas aeruginosa PAO1 | 32 | assay format | Scientific Literature | ||
| 11. | ALA1820904 | B | Inhibition of Pseudomonas aeruginosa LasR | Pseudomonas aeruginosa | 6 | single protein format | Scientific Literature | ||
| 12. | ALA1827783 | F | Antagonist activity at Pseudomonas aeruginosa LasR receptor assessed as inhibition of bioluminescence by reporter gene assay | Pseudomonas aeruginosa | 9 | assay format | Scientific Literature | ||
| 13. | ALA1827921 | F | Agonist activity at Pseudomonas aeruginosa LasR receptor expressed in Escherichia coli in absence of natural autoinducer | Pseudomonas aeruginosa | 4 | assay format | Scientific Literature | ||
| 14. | ALA1827922 | F | Antagonist activity at Pseudomonas aeruginosa LasR receptor expressed in Escherichia coli in presence of 7.5 nM natural auto-inducer 3-oxo-C12-HSL | Pseudomonas aeruginosa | 8 | assay format | Scientific Literature | ||
| 15. | ALA1827923 | F | Agonist activity at Pseudomonas aeruginosa LasR cognate receptor expressed in Escherichia coli harboring pKDT17 assessed as activation of lasB expression by LacZ reporter gene assay | Pseudomonas aeruginosa | 8 | assay format | Scientific Literature | ||
| 16. | ALA3118159 | B | Antagonist activity at LasR in Pseudomonas aeruginosa PAO-JP2 expressing LasI assessed as inhibition of GFP production at 50 to 300 uM after 24 hrs by fluorescence assay in presence of 3-oxo-C12-HSL | Pseudomonas aeruginosa | 4 | single protein format | Scientific Literature | ||
| 17. | ALA3118160 | B | Antagonist activity at LasR in Pseudomonas aeruginosa PAO1 expressing LasI assessed as inhibition of GFP production at 50 to 300 uM after 24 hrs by fluorescence assay relative to control | Pseudomonas aeruginosa PAO1 | 2 | single protein format | Scientific Literature | ||
| 18. | ALA3118161 | B | Antagonist activity at LasR in Pseudomonas aeruginosa PAO1 expressing LasI assessed as inhibition of GFP production at 300 uM after 24 hrs by fluorescence assay relative to control | Pseudomonas aeruginosa PAO1 | 2 | single protein format | Scientific Literature | ||
| 19. | ALA3118162 | B | Antagonist activity at LasR in Pseudomonas aeruginosa PAO1 expressing LasI assessed as inhibition of GFP production at 50 to 150 uM after 24 hrs by fluorescence assay | Pseudomonas aeruginosa PAO1 | 2 | single protein format | Scientific Literature | ||
| 20. | ALA3226603 | B | Antagonist activity at LasR in Pseudomonas aeruginosa PAO1 assessed as inhibition of biofilm formation at 0.3 to 333 uM after 20 hrs by crystal violet staining assay | Pseudomonas aeruginosa PAO1 | 2 | single protein format | Scientific Literature |
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