# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA650541 | B | Displacement of [3H]PK11195 binding from peripheral benzodiazepine receptor in MA-10 mouse tumor Leydig cells | Mus musculus | 2 | cell-based format | Scientific Literature | ||
2. | ALA908530 | B | Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in ddy mouse olfactory bulb at 1 mg/kg, iv after 30 mins relative to control | Mus musculus | 2 | organism-based format | Scientific Literature | ||
3. | ALA908531 | B | Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in ddy mouse cerebellum at 1 mg/kg, iv after 30 mins relative to control | Mus musculus | 2 | organism-based format | Scientific Literature | ||
4. | ALA908532 | B | Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in ddy mouse striatum at 1 mg/kg, iv after 30 mins relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
5. | ALA908533 | B | Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in ddy mouse hippocampus at 1 mg/kg, iv after 30 mins relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
6. | ALA908534 | B | Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in ddy mouse hypothalamus at 1 mg/kg, iv after 30 mins relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
7. | ALA908535 | B | Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in ddy mouse cerebral cortex at 1 mg/kg, iv after 30 mins relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
8. | ALA984212 | B | Binding affinity to mitochondrial TSPO in mouse MA10 cells in presence of human chorionic gonadotropin | Mus musculus | 1 | cell-based format | Scientific Literature | ||
9. | ALA3878759 | B | Inhibition of TSPO in mouse HT22 cells assessed as protection against amyloid beta (1 to 42)-induced mitochondrial membrane potential loss by measuring recovery of mitochondrial membrane potential at 5 uM preincubated for 10 mins followed by amyloid beta (1 to 42) addition measured every 1 hr for 3 hrs by JC1 staining based fluorescence assay relative to control | Mus musculus | 59 | cell-based format | Scientific Literature | ||
10. | ALA3878760 | B | Inhibition of TSPO in mouse HT22 cells assessed as protection against amyloid beta (1 to 42)-induced mitochondrial membrane potential loss by measuring recovery of ATP production at 5 uM preincubated for 10 mins followed by amyloid beta (1 to 42) addition measured after 7 hrs by luciferase reporter gene assay relative to control | Mus musculus | 25 | cell-based format | Scientific Literature | ||
11. | ALA3878762 | B | Inhibition of TSPO in mouse HT22 cells assessed as inhibition of amyloid beta (1 to 42)-induced toxicity at 5 uM after 24 hrs by MTT assay relative to control | Mus musculus | 10 | cell-based format | Scientific Literature | ||
12. | ALA3878763 | B | Inhibition of TSPO in mouse HT22 cells assessed as inhibition of amyloid beta (1 to 42)-induced ROS generation at 5 uM after 6 hrs by DCFDA staining based fluorescence assay relative to control | Mus musculus | 10 | cell-based format | Scientific Literature | ||
13. | ALA3878790 | B | Inhibition of TSPO in mouse HT22 cells assessed as inhibition of amyloid beta (1 to 42)-induced mitochondrial permeability transition pore opening by measuring decrease in intracellular calcium level after 30 mins by Fura-2-AM dye based fluorescence assay | Mus musculus | 2 | cell-based format | Scientific Literature | ||
14. | ALA4135330 | B | Inhibition of TSPO in mouse HT22 cells assessed as reduction in amyloid beta (1 to 42) (unknown origin) induced mitochondrial permeability transition pore formation by measuring increase in green to red fluorescence ratio at 5 uM pretreated for 10 mins followed by amyloid beta (1 to 42) stimulation and measured at 1 hr interval for 3 hrs by JC-1 dye based fluorescence assay relative to control | Mus musculus | 63 | cell-based format | Scientific Literature | ||
15. | ALA4135331 | B | Inhibition of TSPO in mouse HT22 cells assessed as recovery of ATP production at 5 uM preincubated for 10 mins followed by amyloid beta (1 to 42) stimulation and measured after 7 hrs by luciferase based assay relative to control | Mus musculus | 63 | cell-based format | Scientific Literature |