| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1007110 | B | Binding affinity to Trypanosoma cruzi CYP51 expressed in Escherichia coli by spectral titration | Trypanosoma cruzi | 13 | assay format | Scientific Literature | ||
| 2. | ALA1006261 | B | Inhibitory potency at Trypanosoma cruzi CYP51 assessed as molar ratio of drug to enzyme required to slow down the reaction twofold at 1 uM enzyme concentration | Trypanosoma cruzi | 14 | assay format | Scientific Literature | ||
| 3. | ALA1004934 | B | Binding affinity to Trypanosoma cruzi lanosterol 14-alpha-demethylase expressed in Escherichia coli assessed as enzyme spectral change by difference spectroscopy | Trypanosoma cruzi | 2 | assay format | Scientific Literature | ||
| 4. | ALA1004935 | B | Binding affinity to Trypanosoma cruzi lanosterol 14-alpha-demethylase expressed in Escherichia coli assessed as equilibrium dissociation constant for enzyme-inhibitor complex by difference spectroscopy | Trypanosoma cruzi | 2 | assay format | Scientific Literature | ||
| 5. | ALA1022140 | B | Inhibition of Trypanosoma cruzi recombinant sterol 14-alpha-demethylase assessed as drug/enzyme molar ratio required to produce 50 percent decrease in turnover number | Trypanosoma cruzi | 6 | single protein format | Scientific Literature | ||
| 6. | ALA1111996 | B | Binding affinity to Trypanosoma cruzi recombinant lanosterol 14-alpha-demethylase by optical spectroscopy | Trypanosoma cruzi | 1 | single protein format | Scientific Literature | ||
| 7. | ALA1261627 | B | Inhibition of sterol 14-alpha-demethylase in Trypanosoma cruzi epimastigotes infected in BESM cell assessed as cell death at 10 uM after 72 hrs by electron microscopy | Trypanosoma cruzi | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA1261628 | B | Inhibition of sterol 14-alpha-demethylase in Trypanosoma cruzi epimastigotes infected in BESM cell assessed as abnormalities in nuclear DNA at 10 uM after 72 hrs by electron microscopy | Trypanosoma cruzi | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA1261629 | B | Inhibition of sterol 14-alpha-demethylase in Trypanosoma cruzi epimastigotes infected in BESM cell assessed as abnormalities in nuclear membrane at 10 uM after 72 hrs by electron microscopy | Trypanosoma cruzi | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA1261630 | B | Inhibition of sterol 14-alpha-demethylase in Trypanosoma cruzi amastigotes infected in BESM cell assessed as cell death at 0.25 uM after 72 hrs by electron microscopy | Trypanosoma cruzi | 1 | single protein format | Scientific Literature | ||
| 11. | ALA1261631 | B | Inhibition of sterol 14-alpha-demethylase in Trypanosoma cruzi amastigotes infected in BESM cell assessed as abnormalities in nuclear DNA at 0.25 uM after 72 hrs by electron microscopy | Trypanosoma cruzi | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA1261632 | B | Inhibition of sterol 14-alpha-demethylase in Trypanosoma cruzi amastigotes infected in BESM cell assessed as abnormalities in nuclear membrane at 0.25 uM after 72 hrs by electron microscopy | Trypanosoma cruzi | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA1261633 | B | Inhibition of sterol 14-alpha-demethylase in Trypanosoma cruzi amastigotes infected in BESM cell assessed as cell death at 10 uM after 72 hrs by electron microscopy | Trypanosoma cruzi | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA1261634 | B | Inhibition of sterol 14-alpha-demethylase in Trypanosoma cruzi amastigotes infected in BESM cell assessed as abnormalities in nuclear DNA at 10 uM after 72 hrs by electron microscopy | Trypanosoma cruzi | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA1261635 | B | Inhibition of sterol 14-alpha-demethylase in Trypanosoma cruzi amastigotes infected in BESM cell assessed as abnormalities in nuclear membrane at 10 uM after 72 hrs by electron microscopy | Trypanosoma cruzi | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA1261636 | B | Inhibition of sterol 14-alpha-demethylase in Trypanosoma cruzi amastigotes infected in BESM cell assessed as appearance of large autophagic vesicles at 0.25 uM after 48 hrs by electron microscopy | Trypanosoma cruzi | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA1261637 | B | Inhibition of sterol 14-alpha-demethylase in Trypanosoma cruzi amastigotes infected in BESM cell assessed as swelling of nuclear membrane at 0.25 uM after 48 hrs by electron microscopy | Trypanosoma cruzi | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA1261638 | B | Inhibition of sterol 14-alpha-demethylase in Trypanosoma cruzi amastigotes infected in BESM cell assessed as blebbing of the cell membrane at 0.25 uM after 48 hrs by electron microscopy | Trypanosoma cruzi | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA1261639 | B | Inhibition of sterol 14-alpha-demethylase in Trypanosoma cruzi amastigotes infected in BESM cell assessed as appearance of large autophagic vesicles at 10 uM after 48 hrs by electron microscopy | Trypanosoma cruzi | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA1261640 | B | Inhibition of sterol 14-alpha-demethylase in Trypanosoma cruzi amastigotes infected in BESM cell assessed as swelling of nuclear membrane at 10 uM after 48 hrs by electron microscopy | Trypanosoma cruzi | 1 | cell-based format | Scientific Literature |
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