| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1102312 | B | Activation of human TLR3 expressed in HEK293 assessed as induction of NF-kappaB activity reporter gene assay | Homo sapiens | 32 | ALA1154352 | cell-based format | Scientific Literature | |
| 2. | ALA2020651 | F | Agonist activity at human TLR3 HEK-Blue cells assessed as increase in NFkappaB activation by sAP reporter gene assay | Homo sapiens | 16 | ALA2016459 | cell-based format | Scientific Literature | |
| 3. | ALA2166308 | F | Agonist activity at human TLR3 expressed in Ramos blue cells assessed as stimulation of NF-kB/AP-1 activity at 20 uM incubated for 18 hrs using quanti blue assay based SEAP reporter gene assay | Homo sapiens | 8 | ALA2163344 | cell-based format | Scientific Literature | |
| 4. | ALA2187106 | F | Agonist activity at human TLR3 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline phosphatase up to 250 uM by HEK-blue reporter gene assay | Homo sapiens | 22 | ALA2176888 | cell-based format | Scientific Literature | |
| 5. | ALA2389993 | B | Activation of human TLR3 transfected in HEK293 cells at 10 uM after 20 to 24 hrs by SEAP assay | Homo sapiens | 1 | ALA2384907 | cell-based format | Scientific Literature | |
| 6. | ALA2422063 | B | Antagonist activity at human TLR3 expressed in HEK293 cells co-transfected with MD2 and sAP assessed as inhibition of NF-kappaB activity by reporter gene assay | Homo sapiens | 4 | ALA2417394 | cell-based format | Scientific Literature | |
| 7. | ALA2424008 | B | Modulation of human TLR3 expressed in HEK293 cells co-transfected with MD2 and sAP assessed as induction of NF-kappaB activity by reporter gene assay | Homo sapiens | 29 | ALA2417394 | cell-based format | Scientific Literature | |
| 8. | ALA3270133 | B | Agonist activity at human recombinant TLR3 expressed in HEK293 cells at 10 uM by SEAP reporter assay | Homo sapiens | 1 | ALA3259572 | cell-based format | Scientific Literature | |
| 9. | ALA3365534 | B | Agonist activity at human TLR3 stably expressed in HEK293 cells co-expressing secreted alkaline phosphatase assessed as NF-kappaB induction by liquid handler-assisted reporter gene assay | Homo sapiens | 33 | ALA3352666 | cell-based format | Scientific Literature | |
| 10. | ALA4008412 | B | Activity at human TLR3 expressed in HEK293 cells co-expressing secreted alkaline phosphatase assessed as induction of NF-kappaB/AP-1 promoter activity by measuring increase in secreted alkaline phosphatase level by spectrophotometric method | Homo sapiens | 38 | ALA4007404 | cell-based format | Scientific Literature | |
| 11. | ALA4010323 | B | Inhibition of TLR3 in human PBMC assessed as reduction in poly(I:C)-stimulated IL-6 expression at 1 uM by ELISA relative to control | Homo sapiens | 1 | ALA4007458 | assay format | Scientific Literature | |
| 12. | ALA4010324 | B | Inhibition of human TLR3 expressed in HEK293 cells assessed as reduction in poly(I:C)-induced NF-kB activation up to 5 uM after 18 hrs by luciferase reporter gene assay | Homo sapiens | 1 | ALA4007458 | cell-based format | Scientific Literature | |
| 13. | ALA4010326 | B | Inhibition of TLR3 in human PBMC assessed as reduction in poly(I:C)-stimulated IL-6 expression at 1 to 10 uM by ELISA relative to control | Homo sapiens | 1 | ALA4007458 | assay format | Scientific Literature | |
| 14. | ALA4016457 | B | Agonist activity at human TLR3 expressed in HEK293 cells assessed as induction of NF-kB activation-mediated SEAP production at 30 uM after 24 hrs by HTS assay | Homo sapiens | 1 | ALA4014338 | cell-based format | Scientific Literature | |
| 15. | ALA4016458 | B | Agonist activity at human TLR3 expressed in HEK293 cells assessed as induction of NF-kB activation-mediated SEAP production after 24 hrs by HTS assay | Homo sapiens | 26 | ALA4014338 | cell-based format | Scientific Literature | |
| 16. | ALA4016460 | B | Agonist activity at human TLR3 expressed in HEK293 cells assessed as induction of NF-kB activation-mediated SEAP production at 25 uM after 24 hrs by HTS assay relative to control | Homo sapiens | 26 | ALA4014338 | cell-based format | Scientific Literature | |
| 17. | ALA4035644 | B | Antagonist activity at TLR3 in human THP1 cells assessed as inhibition of poly IC-stimulated IL-6 mRNA level after 16 hrs by RT-PCR method | Homo sapiens | 1 | ALA4033685 | cell-based format | Scientific Literature | |
| 18. | ALA4035645 | B | Antagonist activity at TLR3 in human THP1 cells assessed as inhibition of poly IC-stimulated RANTES mRNA level after 16 hrs by RT-PCR method | Homo sapiens | 1 | ALA4033685 | cell-based format | Scientific Literature | |
| 19. | ALA4035650 | B | Antagonist activity at TLR3 in human THP1 cells assessed as inhibition of poly IC-stimulated IL-6 mRNA level at 10 uM after 16 hrs by RT-PCR method | Homo sapiens | 2 | ALA4033685 | cell-based format | Scientific Literature | |
| 20. | ALA4035651 | B | Antagonist activity at TLR3 in human THP1 cells assessed as inhibition of poly IC-stimulated RANTES mRNA level at 10 uM after 16 hrs by RT-PCR method | Homo sapiens | 2 | ALA4033685 | cell-based format | Scientific Literature |
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