| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1908257 | A | Mechanism based inhibition of rat cytochrome P450 CYP1A2 | Rattus norvegicus | 1 | single protein format | Scientific Literature | ||
| 2. | ALA1908258 | A | Mechanism based inhibition of rat cytochrome P450 CYP1A2 measured by 7-methoxyresorufin O-demethylation (MROD) | Rattus norvegicus | 4 | single protein format | Scientific Literature | ||
| 3. | ALA1908259 | A | Mechanism based inhibition of rat cytochrome P450 CYP1A2 measured by zolmitriptan metabolism | Rattus norvegicus | 1 | single protein format | Scientific Literature | ||
| 4. | ALA1116315 | A | Intrinsic clearance in rat liver microsomes assessed per mg of protein up to 60 mins in presence of rat recombinant CYP1A2 | Rattus norvegicus | 16 | microsome format | Scientific Literature | ||
| 5. | ALA2328462 | A | Inhibition of CYP1A2 in rat liver microsome using phenacetin as substrate by HPLC-PDA analysis | Rattus norvegicus | 1 | microsome format | Scientific Literature | ||
| 6. | ALA2340590 | A | Drug metabolism in Wistar rat assessed as CYP1A2-mediated decrease in parent compound level at 50 mg/kg, ip after 30 mins by HPLC analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA2340591 | A | Drug metabolism in Wistar rat assessed as CYP1A2-mediated p-hydroxylated metabolite formation at 50 mg/kg, ip after 30 mins by HPLC analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA2340592 | A | Drug metabolism in Wistar rat assessed as CYP1A2-mediated decrease in parent compound level at 50 mg/kg, ip after 48 hrs by HPLC analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA2340593 | A | Drug metabolism in Wistar rat assessed as CYP1A2-mediated p-hydroxylated metabolite formation at 50 mg/kg, ip after 48 hrs by HPLC analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA3537362 | A | Prodrug conversion assessed as rat recombinant CYP1A2-mediated (Z)-N'-hydroxy-6-(5-(5-((Z)-N'-methoxycarbamimidoyl)pyridin-2-yl)furan-2-yl) nicotinimidamide formation at 5 uM after 180 mins incubation by HPLC-UV chromatogram | Rattus norvegicus | 1 | single protein format | Scientific Literature | ||
| 11. | ALA3537365 | A | Prodrug conversion assessed as rat recombinant CYP1A2-mediated (3Z,3'Z)-6,6'-(furan-2,5-diyl)bis(N'-hydroxynicotinimidamide) formation at 5 uM after 180 mins incubation by HPLC-UV chromatogram | Rattus norvegicus | 1 | single protein format | Scientific Literature | ||
| 12. | ALA3537366 | A | Drug metabolism in rat recombinant CYP1A2 treated with at 5 uM DB868 after 180 mins incubation by HPLC-UV chromatography | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
| 13. | ALA3540948 | A | Activity of CYP1A2 in rat liver microsomes assessed as enzyme mediated compound formation treated with 10 uM setileuton after 2 mins in presence of NADPH (Rvb = 8.10 +/- 2.26 nM) | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 14. | ALA3540949 | A | Activity of CYP1A2 in rat liver microsomes assessed as enzyme mediated compound formation treated with 10 uM setileuton after 5 mins in presence of NADPH (Rvb = 8.10 +/- 2.26 nM) | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 15. | ALA3540950 | A | Activity of CYP1A2 in rat liver microsomes assessed as enzyme mediated compound formation treated with 10 uM setileuton after 8 mins in presence of NADPH (Rvb = 8.10 +/- 2.26 nM) | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 16. | ALA3540951 | A | Activity of CYP1A2 in rat liver microsomes assessed as enzyme mediated compound formation treated with 10 uM setileuton after 10 mins in presence of NADPH (Rvb = 8.10 +/- 2.26 nM) | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 17. | ALA3540952 | A | Activity of CYP1A2 in rat liver microsomes assessed as enzyme mediated compound formation treated with 10 uM setileuton after 2 mins in absence of NADPH (Rvb = 1.93 +/- 0.40 nM) | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 18. | ALA3540953 | A | Activity of CYP1A2 in rat liver microsomes assessed as enzyme mediated compound formation treated with 10 uM setileuton after 5 mins in absence of NADPH (Rvb = 1.93 +/- 0.40 nM) | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 19. | ALA3540954 | A | Activity of CYP1A2 in rat liver microsomes assessed as enzyme mediated compound formation treated with 10 uM setileuton after 8 mins in absence of NADPH (Rvb = 1.93 +/- 0.40 nM) | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 20. | ALA3540955 | A | Activity of CYP1A2 in rat liver microsomes assessed as enzyme mediated compound formation treated with 10 uM setileuton after 10 mins in absence of NADPH (Rvb = 1.93 +/- 0.40 nM) | Rattus norvegicus | 1 | assay format | Scientific Literature |
The page will load shortly, Thanks for your patience!