# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1112503 | B | Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISA | Rattus norvegicus | 18 | ALA1156956 | assay format | Scientific Literature | |
2. | ALA1117042 | B | Inhibition of rat brain mTOR assessed as p70S6K-GST protein phosphorylation after 30 mins by ELISA | Rattus norvegicus | 12 | ALA1156972 | assay format | Scientific Literature | |
3. | ALA1762903 | B | Inhibition of HGF induced mTOR activation in rat liver assessed as inhibition of AKT phosphorylation at S473 at 30 mg/kg, ip 6 hrs prior to HGF stimulation by MSD analysis | Rattus norvegicus | 1 | ALA1759974 | organism-based format | Scientific Literature | |
4. | ALA1762904 | B | Inhibition of HGF induced mTOR activation in rat liver assessed as inhibition of AKT phosphorylation at S473 at 100 mg/kg, ip 6 hrs prior to HGF stimulation by MSD analysis | Rattus norvegicus | 1 | ALA1759974 | organism-based format | Scientific Literature | |
5. | ALA1762905 | B | Inhibition of HGF induced mTOR activation in rat liver assessed as inhibition of S6RP phosphorylation at 100 mg/kg, ip 6 hrs prior to HGF stimulation by MSD analysis | Rattus norvegicus | 1 | ALA1759974 | organism-based format | Scientific Literature | |
6. | ALA2341979 | B | Reversible inhibition of mTOR (unknown origin) assessed as enzyme recovery measured after dilution in presence of ATP relative to untreated control | Homo sapiens | 1 | ALA2331117 | single protein format | Scientific Literature | |
7. | ALA3395880 | B | Inhibition of rat derived mTOR using [gamma32P]ATP | Rattus norvegicus | 1 | ALA3392967 | single protein format | Scientific Literature | |
8. | ALA4032212 | B | Inhibition of mTOR in rat PC12 cells assessed as induction of autophagy at 500 nM after 48 hrs by MDC staining-based flow cytometric method relative to control | Rattus norvegicus | 1 | ALA4028889 | cell-based format | Scientific Literature | |
9. | ALA4381611 | B | Inhibition of mTOR in rat primary cortical neuron assessed as reduction in PS6 phosphorylation incubated for 4 hrs by Western blot analysis (Rvb = 19 nM) | Rattus norvegicus | 1 | ALA4376889 | assay format | Scientific Literature | |
10. | ALA4381612 | B | Inhibition of mTOR S2215F mutant in rat primary cortical neuron assessed as reduction in PS6 phosphorylation incubated for 4 hrs by Western blot analysis (Rvb = 19 nM) | Rattus norvegicus | 1 | ALA4376889 | assay format | Scientific Literature | |
11. | ALA4381613 | B | Inhibition of mTOR S2215Y mutant in rat primary cortical neuron assessed as reduction in PS6 phosphorylation incubated for 4 hrs by Western blot analysis (Rvb = 19 nM) | Rattus norvegicus | 1 | ALA4376889 | assay format | Scientific Literature | |
12. | ALA4381614 | B | Inhibition of mTOR L1460P mutant in rat primary cortical neuron assessed as reduction in PS6 phosphorylation incubated for 4 hrs by Western blot analysis (Rvb = 19 nM) | Rattus norvegicus | 1 | ALA4376889 | assay format | Scientific Literature | |
13. | ALA4381615 | B | Inhibition of mTOR C1483Y mutant in rat primary cortical neuron assessed as reduction in PS6 phosphorylation incubated for 4 hrs by Western blot analysis (Rvb = 19 nM) | Rattus norvegicus | 1 | ALA4376889 | assay format | Scientific Literature | |
14. | ALA4381616 | B | Inhibition of mTOR L2427P mutant in rat primary cortical neuron assessed as reduction in PS6 phosphorylation incubated for 4 hrs by Western blot analysis (Rvb = 19 nM) | Rattus norvegicus | 1 | ALA4376889 | assay format | Scientific Literature | |
15. | ALA4381617 | B | Inhibition of mTOR E2419K mutant in rat primary cortical neuron assessed as reduction in PS6 phosphorylation incubated for 4 hrs by Western blot analysis (Rvb = 19 nM) | Rattus norvegicus | 1 | ALA4376889 | assay format | Scientific Literature | |
16. | ALA5112231 | B | Inhibition of rat brain mTOR using GST-p70S6K fusion protein as substrate preincubated for 30 mins followed by ATP addition and measured after 30 mins by K-Lisa assay | Rattus norvegicus | 1 | ALA5108059 | tissue-based format | Scientific Literature | |
17. | ALA5231761 | B | Inhibition of mTOR in rat brain by [3H]-thymidine incorporation based immunoblot assay | Rattus norvegicus | 1 | ALA5230127 | tissue-based format | Scientific Literature |