| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2150722 | F | Antagonist activity at Pseudomonas aeruginosa LasB using Abz-Ala-Gly-Leu-Ala-p-Nitro-Benzyl-Amide as substrate incubated for 30 mins prior to substrate addition by FRET assay | Pseudomonas aeruginosa | 13 | assay format | Scientific Literature | ||
| 2. | ALA2150723 | F | Antagonist activity at Pseudomonas aeruginosa PA14 LasB assessed as inhibition of swarming at 25 uM after 16 hrs swarming motility assay relative to control | Pseudomonas aeruginosa PA14 | 4 | assay format | Scientific Literature | ||
| 3. | ALA1107602 | B | Inhibition of Pseudomonas aeruginosa LasB by fluorimetric assay in buffer of pH 7.2 | Pseudomonas aeruginosa | 160 | single protein format | Scientific Literature | ||
| 4. | ALA5257257 | B | Inhibition of Pseudomonas aeruginosa PAO1 elastase at 250 uM relative to control | Pseudomonas aeruginosa | 1 | single protein format | Scientific Literature | ||
| 5. | ALA5257261 | B | Inhibition of Pseudomonas aeruginosa PAO1 elastase at 200 uM relative to control | Pseudomonas aeruginosa | 1 | single protein format | Scientific Literature | ||
| 6. | ALA5257279 | B | Inhibition of Pseudomonas aeruginosa LasB elastase using aminobenzoyl-Ala-Gly-Leu-Ala-p-nitro-benzyl-amide as substrate b microtiter-based fluorimetric assay | Pseudomonas aeruginosa | 5 | single protein format | Scientific Literature | ||
| 7. | ALA5257280 | B | Inhibition of Pseudomonas aeruginosa LasB elastase | Pseudomonas aeruginosa | 1 | single protein format | Scientific Literature | ||
| 8. | ALA3376524 | B | Inhibition of Pseudomonas aeruginosa pseudolysin using Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(Dnp)-OH as substrate after 1 hr by fluorescence assay in presence of Brij-35 | Pseudomonas aeruginosa | 14 | single protein format | Scientific Literature | ||
| 9. | ALA3376525 | B | Inhibition of Pseudomonas aeruginosa pseudolysin using Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide as substrate after 15 mins | Pseudomonas aeruginosa | 14 | single protein format | Scientific Literature | ||
| 10. | ALA3404730 | B | Antagonist activity at lasB in Pseudomonas aeruginosa harboring lasB-gfp gene assessed as inhibition of 3-oxo-C6-HSL-induced quorum sensing by green fluorescence protein reporter assay | Pseudomonas aeruginosa | 13 | assay format | Scientific Literature | ||
| 11. | ALA3756035 | B | Inhibition of Bacillus thermoproteolyticus pseudolysin pretreated with compound for 15 mins followed by the addition of Abz-Ala-Gly-leu-Ala-p-nitrobenzalamide as substrate by spectrofluorometry | Pseudomonas aeruginosa | 10 | single protein format | Scientific Literature | ||
| 12. | ALA3756036 | B | Inhibition of Pseudomonas aeruginosa pseudolysin pretreated with compound for 1 hr followed by the addition of 1.73 uM bradykinin like substrate by spectrofluorometry | Pseudomonas aeruginosa | 10 | single protein format | Scientific Literature | ||
| 13. | ALA4146049 | B | Inhibition of Pseudomonas aeruginosa PAO1 GFP-fused quorum sensing lasB at 10 uM measured every 15 mins up to 12 hrs by GFP reporter gene assay relative to control | Pseudomonas aeruginosa PAO1 | 28 | single protein format | Scientific Literature | ||
| 14. | ALA4268463 | B | Inhibition of Pseudomonas aeruginosa PAO1 GFP-fused quorum sensing lasB up to 40 uM measured every 15 mins up to 12 hrs by GFP reporter gene assay | Pseudomonas aeruginosa PAO1 | 1 | single protein format | Scientific Literature | ||
| 15. | ALA4268468 | B | Inhibition of Pseudomonas aeruginosa PAO1 GFP-fused quorum sensing lasB assessed as decrease in elastase activity up to 40 uM incubated for 24 hrs recorded every 10 mins for 3 hrs | Pseudomonas aeruginosa PAO1 | 1 | single protein format | Scientific Literature | ||
| 16. | ALA4383805 | B | Inhibition of lasB quorum sensing system in Pseudomonas aeruginosa PAO1 harboring mini-ctx-lasB-lacZ after 24 hrs by beta-galactosidase reporter gene assay | Pseudomonas aeruginosa PAO1 | 1 | single protein format | Scientific Literature | ||
| 17. | ALA4383808 | B | Inhibition of lasB quorum sensing system in Pseudomonas aeruginosa PAO1 assessed as reduction in elastase release at 10 uM after 24 hrs relative to control | Pseudomonas aeruginosa PAO1 | 1 | single protein format | Scientific Literature | ||
| 18. | ALA4383810 | B | Inhibition of lasB quorum sensing system in Pseudomonas aeruginosa PAO1 harboring mini-ctx-lasB-lacZ at 50 uM in presence of ODdHL by beta-galactosidase reporter gene assay | Pseudomonas aeruginosa PAO1 | 1 | single protein format | Scientific Literature | ||
| 19. | ALA4423833 | B | Inhibition of lasB in Pseudomonas aeruginosa PAO1 containing lasB-lacZ translational reporter fusion at 20 uM after 16 hrs by LacZ reporter gene assay | Pseudomonas aeruginosa PAO1 | 2 | single protein format | Scientific Literature | ||
| 20. | ALA4621227 | B | Inhibition of Pseudomonas aeruginosa PA14 LasB using 2-Aminobenzoyl-AlaGly-Leu-Ala-4-Nitrobenzylamide as fluorogenic substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by FRET assay | Pseudomonas aeruginosa PA14 | 32 | single protein format | Scientific Literature |
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