# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1107106 | F | Agonist activity at human recombinant alpha 3 GlyR expressed in HEK293 cells assessed as potentiation of glycine current by whole cell patch clamp assay | Homo sapiens | 10 | ALA1156225 | cell-based format | Scientific Literature | |
2. | ALA1107107 | F | Agonist activity at human recombinant alpha 3 GlyR expressed in HEK293 cells assessed as potentiation of glycine current up to 100 uM by whole cell patch clamp assay | Homo sapiens | 1 | ALA1156225 | cell-based format | Scientific Literature | |
3. | ALA1107108 | F | Agonist activity at human recombinant alpha 3 GlyR expressed in HEK293 cells assessed as potentiation of glycine current at 100 uM by whole cell patch clamp assay relative to EC20 glycine maximum response | Homo sapiens | 1 | ALA1156225 | cell-based format | Scientific Literature | |
4. | ALA1107110 | F | Antagonist activity at human recombinant alpha 3 GlyR expressed in HEK293 cells assessed as inhibition of glycine current influx by whole cell patch clamp assay | Homo sapiens | 11 | ALA1156225 | cell-based format | Scientific Literature | |
5. | ALA2401361 | B | Modulation of recombinant GlyR-alpha3 (unknown origin) expressed in HEK293 cells assessed as inhibition of glycine-induced current by automated planar patch-clamp automated electrophysiology assay | Homo sapiens | 3 | ALA2396546 | cell-based format | Scientific Literature | |
6. | ALA3993230 | B | Positive allosteric modulation of human glycine alpha3 receptor expressed in HEK293T cells assessed as potentiation of glycine-induced increase in chloride ion flux after 4 mins by membrane potential blue dye based FLIPR assay | Homo sapiens | 4 | ALA3992512 | cell-based format | Scientific Literature | |
7. | ALA3993231 | B | Binding affinity to human glycine alpha3 receptor expressed in HEK293T cells by SPR assay | Homo sapiens | 4 | ALA3992512 | cell-based format | Scientific Literature | |
8. | ALA4219614 | B | Positive allosteric modulation of recombinant human glycine receptor alpha3 expressed in CHOK1 cells at -60 mV holding potential by whole cell patch-clamp method | Homo sapiens | 1 | ALA4219030 | cell-based format | Scientific Literature | |
9. | ALA4219615 | B | Positive allosteric modulation of recombinant human glycine receptor alpha3 expressed in CHOK1 cells assessed as potentiation of glycine-induced current at 20 uM at -60 mV holding potential by whole cell patch-clamp method relative to glycine | Homo sapiens | 1 | ALA4219030 | cell-based format | Scientific Literature | |
10. | ALA4219621 | B | Positive allosteric modulation of human glycine alpha3 receptor expressed in HEK293T cells assessed as glycine-induced increase in current response after 18 to 24 hrs by membrane potential blue dye based FLIPR assay | Homo sapiens | 2 | ALA4219030 | cell-based format | Scientific Literature | |
11. | ALA4219930 | B | Positive allosteric modulation of human GlyRalpha3 expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium dye-5 based FLIPR assay | Homo sapiens | 1 | ALA4219040 | cell-based format | Scientific Literature | |
12. | ALA4219936 | B | Positive allosteric modulation of human GlyRalpha3 expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium dye-5 based FLIPR assay relative to glycine | Homo sapiens | 1 | ALA4219040 | cell-based format | Scientific Literature | |
13. | ALA4219944 | B | Positive allosteric modulation of human GlyRalpha3 expressed in HEK293 cells assessed as potentiation of glycine-induced current flux at 100 uM by electrophysiology method relative to control | Homo sapiens | 1 | ALA4219040 | cell-based format | Scientific Literature | |
14. | ALA4219945 | B | Positive allosteric modulation of human GlyRalpha3 expressed in HEK293 cells assessed as potentiation of glycine-induced current flux by electrophysiology method | Homo sapiens | 1 | ALA4219040 | cell-based format | Scientific Literature | |
15. | ALA4252018 | B | Binding affinity to human GlyRalpha3cryst by SPR method | Homo sapiens | 2 | ALA4251550 | single protein format | Scientific Literature |