| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2049617 | F | Agonist activity at mouse TLR2 expressed in HEK293 cells assessed as NFkappaB translocation after 12 hrs by secretory alkaline phosphatase reporter gene assay | Mus musculus | 5 | cell-based format | Scientific Literature | ||
| 2. | ALA2049620 | F | Antagonistic activity at mouse TLR2 expressed in HEK293 cells assessed as inhibition of PAM2CS-induced NFkappaB translocation by secretory alkaline phosphatase reporter gene assay | Mus musculus | 6 | cell-based format | Scientific Literature | ||
| 3. | ALA2049622 | F | Antagonistic activity at mouse TLR2 expressed in HEK293 cells assessed as inhibition of lipoteichoic acid-induced NFkappaB translocation by secretory alkaline phosphatase reporter gene assay | Mus musculus | 6 | cell-based format | Scientific Literature | ||
| 4. | ALA1115013 | B | Induction of TLR2-mediated mouse D1 dendritic cells maturation assessed as expression of CD54 and CD86 activation markers at 0.5 ug/ml to 5 ug/ml after 24 hrs by flow cytometry in the presence of polymyxin B | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 5. | ALA1115014 | B | Induction of TLR2-mediated mouse spleen B cells proliferation assessed as [3H]thymidin uptake at 0.02 ug/ml after 72 hrs | Mus musculus | 4 | tissue-based format | Scientific Literature | ||
| 6. | ALA1115868 | F | Induction of TLR2-mediated mouse D1 dendritic cells maturation assessed as expression of CD54 and CD86 activation markers at 0.5 ug/ml to 5 ug/ml after 24 hrs by flow cytometry in the presence of antagonist anti-TLR2 antibody treated 25 mins after anti-TLR2 antibody challenge | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 7. | ALA1115869 | F | Induction of TLR2-mediated mouse spleen B cells proliferation assessed as [3H]thymidin uptake at 0.16 ug/ml after 72 hrs in the presence of antagonist anti-TLR2 antibody treated 25 mins after anti-TLR2 antibody challenge | Mus musculus | 4 | tissue-based format | Scientific Literature | ||
| 8. | ALA1226061 | B | Inhibition TLR2-mediated NO production in mouse RAW264.7 cells at 300 uM | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA2209300 | B | Inhibition of MyD88 recruitment to TLR2 in C57BL/6 mouse BMDM cells assessed as inhibition of HKSA-induced IkappaBalpha degradation up to 90 mins by Western blot analysis | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA2209301 | B | Inhibition of MyD88 recruitment to TLR2 in C57BL/6 mouse BMDM cells assessed as inhibition of HKSA-induced IkappaBalpha phosphorylation up to 90 mins by Western blot analysis | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 11. | ALA3789078 | B | Inhibition of TLR2 in mouse RAW264.7 cells assessed as inhibition of Pam3CK-induced IL-6 level at 5 to 10 uM preincubated for 2 hrs followed by Pam3CK addition measured after 12 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA3789079 | B | Inhibition of TLR2 in mouse RAW264.7 cells assessed as inhibition of Pam3CK-induced TNF-alpha level at 5 to 10 uM preincubated for 2 hrs followed by Pam3CK addition measured after 12 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA3820856 | B | Agonist activity at TLR2 in H-2b harboring B6 mouse DC assessed as cell maturation by measuring increase in IL-12 p40 production at 0.0625 to 1 uM incubated for 48 hrs by sandwich ELISA | Mus musculus | 6 | single protein format | Scientific Literature | ||
| 14. | ALA3874904 | B | Binding affinity to TLR-2 in C57BL/6 mouse peritoneal exudate macrophages assessed as cells binding to PE conjugated anti-TLR-2 monoclonal antibody at 10 ug/ml preincubated for 4 hrs followed by antibody addition by flow cytometry (Rvb = 30.8%) | Mus musculus | 1 | assay format | Scientific Literature | ||
| 15. | ALA4222360 | B | Antagonist activity at TLR2 in mouse Raw 264.7 cells assessed as decrease in Pam3CSK4-induced iNOS levels at 40 uM after 24 hrs relative to positive control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4222925 | B | Inhibition of biotin labelled Pam2CSK4 binding to mouse TLR2 Fc chimera protein after 45 mins by AlphaScreen assay | Mus musculus | 6 | single protein format | Scientific Literature | ||
| 17. | ALA4398996 | B | Antagonist activity at TLR2 in mouse RAW264.7 cells assessed as PAM3CSK4-induced NO production measured after 24 hrs by Griess assay | Mus musculus | 34 | cell-based format | Scientific Literature | ||
| 18. | ALA4399000 | B | Antagonist activity at TLR2 in mouse RAW264.7 cells assessed as PAM3CSK4-induced NO production at 150 uM measured after 24 hrs by Griess assay | Mus musculus | 6 | cell-based format | Scientific Literature | ||
| 19. | ALA4399008 | B | Inhibition of TLR2 in mouse RAW264.7 cells assessed as decrease in PAM3CSK4 induced TNF-alpha expression at 25 uM measured after 24 hrs by ELISA relative to control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4399011 | B | Inhibition of TLR2 in mouse RAW264.7 cells assessed as decrease in PAM3CSK4 induced TNF-alpha expression measured after 24 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature |
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