# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3830045 | Functional | Antiproliferative activity against FGFR1-amplified human NCI-H1581 cells after 72 hrs by CCK8/MTT assay | Homo sapiens | 36 | ALA3826910 | cell-based format | Scientific Literature | |
2. | ALA3830195 | Functional | Antitumor activity against FGFR1-amplified human NCI-H1581 cells xenografted in nude mouse assessed as tumor growth inhibition at 2 mg/kg, po qd administered for 21 days measured on day 21 post last dose relative to vehicle-treated control | Homo sapiens | 1 | ALA3826910 | organism-based format | Scientific Literature | |
3. | ALA3830196 | Functional | Antitumor activity against human NCI-H1581 cells xenografted in nude mouse assessed as tumor growth inhibition at 10 mg/kg, po qd administered for 21 days measured on day 21 post last dose relative to vehicle-treated control | Homo sapiens | 1 | ALA3826910 | organism-based format | Scientific Literature | |
4. | ALA3830197 | Functional | Antitumor activity against human NCI-H1581 cells xenografted in nude mouse assessed as tumor growth inhibition at 20 mg/kg administered as qd for 21 days measured on day 21 post last dose relative to vehicle-treated control | Homo sapiens | 1 | ALA3826910 | organism-based format | Scientific Literature | |
5. | ALA3830198 | Functional | Antitumor activity against human NCI-H1581 cells xenografted in po dosed nude mouse assessed as tumor growth inhibition administered as qd for 21 days measured on day 21 post last dose | Homo sapiens | 1 | ALA3826910 | organism-based format | Scientific Literature | |
6. | ALA967703 | Functional | Cytotoxicity against human NCI-H1581 cells assessed as fraction of viable cells after 72 hrs relative to control | Homo sapiens | 11 | ALA1149823 | cell-based format | Scientific Literature | |
7. | ALA979760 | Functional | Cytotoxicity against human NCI-H1581 cells expressing wild type BRAF at 0.2 uM assessed as fraction of viable cells after 72 hrs relative to control | Homo sapiens | 1 | ALA1149823 | cell-based format | Scientific Literature | |
8. | ALA979761 | Functional | Cytotoxicity against human NCI-H1581 cells expressing wild type BRAF at 2 uM assessed as fraction of viable cells after 72 hrs relative to control | Homo sapiens | 1 | ALA1149823 | cell-based format | Scientific Literature | |
9. | ALA2363477 | Functional | SANGER: Inhibition of human NCI-H1581 cell growth in a cell viability assay. | Homo sapiens | 137 | ALA1201861 | cell-based format | Sanger Institute Genomics of Drug Sensitivity in Cancer | |
10. | ALA4002776 | Functional | Antiproliferative activity against FGFR2-amplified human NCI-H1581 cells after 72 hrs by CCK8/SRB assay | Homo sapiens | 2 | ALA4002548 | cell-based format | Scientific Literature | |
11. | ALA4002791 | Functional | Antitumor activity against FGFR1-amplified human NCI-H1581 cells xenografted in nude mouse assessed as tumor growth inhibition at 20 mg/kg, po qd administered for 10 days and measured on day 10 post last dose relative to vehicle-treated control | Homo sapiens | 2 | ALA4002548 | organism-based format | Scientific Literature | |
12. | ALA4002793 | Functional | Antitumor activity against FGFR1-amplified human NCI-H1581 cells xenografted in nude mouse assessed as tumor growth inhibition at 5 mg/kg, po qd administered for 10 days and measured on day 10 post last dose relative to vehicle-treated control | Homo sapiens | 1 | ALA4002548 | organism-based format | Scientific Literature | |
13. | ALA4018682 | Functional | Antitumor activity against human NCI-H1581 cells xenografted in nude mouse assessed as tumor growth inhibition at 5 mg/kg, po qd administered for 14 days measured twice per week during compound dosing | Homo sapiens | 1 | ALA4017490 | organism-based format | Scientific Literature | |
14. | ALA4018683 | Functional | Antitumor activity against human NCI-H1581 cells xenografted in nude mouse assessed as tumor growth inhibition at 20 mg/kg, po qd administered for 14 days measured twice per week during compound dosing | Homo sapiens | 1 | ALA4017490 | organism-based format | Scientific Literature | |
15. | ALA4018710 | Functional | Antitumor activity against human NCI-H1581 cells xenografted in po dosed nude mouse assessed as tumor growth inhibition administered as qd for 14 days measured twice per week during compound dosing | Homo sapiens | 1 | ALA4017490 | organism-based format | Scientific Literature | |
16. | ALA4271706 | Functional | Antiproliferative activity against human NCI-H1581 cells expressing FGFR1 after 72 hrs | Homo sapiens | 2 | ALA4270521 | cell-based format | Scientific Literature | |
17. | ALA4382841 | Functional | Antiproliferative activity against FGFR1 amplified human NCI-H1581 cells after 72 hrs by CCK8 or MTT assay | Homo sapiens | 28 | ALA4382193 | cell-based format | Scientific Literature | |
18. | ALA4382879 | Functional | Antitumor activity against FGFR1 amplified human NCI-H1581 cells xenografted in po dosed nude mouse assessed as tumor growth inhibition administered once daily for 14 days | Homo sapiens | 1 | ALA4382193 | organism-based format | Scientific Literature | |
19. | ALA4382881 | Functional | Antitumor activity against FGFR1 amplified human NCI-H1581 cells xenografted in nude mouse assessed as tumor growth inhibition at 100 mg/kg, po administered once daily for 14 days relative to control | Homo sapiens | 1 | ALA4382193 | organism-based format | Scientific Literature | |
20. | ALA4412432 | Functional | Antitumor activity against human NCI-H1581 cells xenografted in nude mouse assessed as tumor growth inhibition at 10 mg/kg, po qd for 7 to 10 days relative to control | Homo sapiens | 1 | ALA4411287 | organism-based format | Scientific Literature |