| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA968592 | F | Cytotoxicity against human NCI-H1703 cells assessed as fraction of viable cells after 72 hrs relative to control | Homo sapiens | 13 | ALA1149823 | cell-based format | Scientific Literature | |
| 2. | ALA1920680 | F | Antiproliferative activity against human NCI-H1703 cells after 72 hrs by MTT assay | Homo sapiens | 6 | ALA1914422 | cell-based format | Scientific Literature | |
| 3. | ALA1920685 | F | Antitumor activity against human NCI-H1703 cells xenografted in athymic NCr Charles river nu/nu mouse assessed as reduction of tumor growth at 6 umol/kg, iv administered 3 times a week for 3 weeks relative to vehicle treated control | Homo sapiens | 2 | ALA1914422 | organism-based format | Scientific Literature | |
| 4. | ALA1920686 | F | Antitumor activity against human NCI-H1703 cells xenografted in athymic NCr Charles river nu/nu mouse assessed as reduction of tumor weight at 6 umol/kg, iv administered 3 times a week for 3 weeks relative to vehicle treated control | Homo sapiens | 2 | ALA1914422 | organism-based format | Scientific Literature | |
| 5. | ALA1920687 | F | Antitumor activity against human NCI-H1703 cells xenografted in athymic NCr nu/nu Charles river mouse assessed as reduction of tumor growth at 8 umol/kg, iv administered 3 times a week for 3 weeks relative to vehicle treated control | Homo sapiens | 1 | ALA1914422 | organism-based format | Scientific Literature | |
| 6. | ALA1920835 | F | Induction of apoptosis in human NCI-H1703 cells assessed as PARP cleavage after 1 to 6 hrs by Western blot analysis | Homo sapiens | 3 | ALA1914422 | cell-based format | Scientific Literature | |
| 7. | ALA1920836 | F | Induction of apoptosis in human NCI-H1703 cells assessed as caspase 3 activation after 1 to 6 hrs by Western blot analysis | Homo sapiens | 3 | ALA1914422 | cell-based format | Scientific Literature | |
| 8. | ALA1920837 | F | Induction of apoptosis in human NCI-H1703 cells assessed as caspase 7 activation after 1 to 6 hrs by Western blot analysis | Homo sapiens | 3 | ALA1914422 | cell-based format | Scientific Literature | |
| 9. | ALA1920838 | F | Cell cycle arrest in human NCI-H1703 cells assessed as accumulation at G2 phase at 1 uM after 6 hrs by FACS analysis (Rvb = 8%) | Homo sapiens | 1 | ALA1914422 | cell-based format | Scientific Literature | |
| 10. | ALA1920939 | F | Induction of apoptosis in human NCI-H1703 cells assessed as apoptotic cells at 1 uM after 6 hrs by FACS analysis (Rvb = 0.05%) | Homo sapiens | 1 | ALA1914422 | cell-based format | Scientific Literature | |
| 11. | ALA1920940 | F | Upregulation of ATF3 expression in human NCI-H1703 cells at 1 uM pretreated with ATF3 siRNA for 48 hrs before compound challenge measured after 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA1914422 | cell-based format | Scientific Literature | |
| 12. | ALA1920941 | F | Induction of apoptosis in human NCI-H1703 cells assessed as PARP p85 cleavage at 1 uM pretreated with ATF3 siRNA for 48 hrs before compound challenge measured after 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA1914422 | cell-based format | Scientific Literature | |
| 13. | ALA1920942 | F | Induction of apoptosis in human NCI-H1703 cells assessed as caspase 3 cleavage at 1 uM pretreated with ATF3 siRNA for 48 hrs before compound challenge measured after 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA1914422 | cell-based format | Scientific Literature | |
| 14. | ALA1920943 | F | Antitumor activity against human NCI-H1703 cells xenografted in NCr nu/nu Charles river mouse assessed as tissue death in tumor at 6 umol/kg, iv administered 3 times a week for 3 weeks by H and E staining method relative to control | Homo sapiens | 2 | ALA1914422 | organism-based format | Scientific Literature | |
| 15. | ALA1920944 | F | Antitumor activity against human NCI-H1703 cells xenografted in NCr nu/nu Charles river mouse assessed as tissue death in tumor at 8 umol/kg, iv administered 3 times a week for 3 weeks by H and E staining method relative to control | Homo sapiens | 1 | ALA1914422 | organism-based format | Scientific Literature | |
| 16. | ALA2026063 | F | Antiproliferative activity against human NCI-H1703 cells after 48 hrs by MTT assay | Homo sapiens | 7 | ALA2021824 | cell-based format | Scientific Literature | |
| 17. | ALA2026066 | A | Metabolic stability in human NCI-H1703 cells assessed as formation of arylated GSH at 5 uM after 5 mins by LC/MS analysis | Homo sapiens | 1 | ALA2021824 | cell-based format | Scientific Literature | |
| 18. | ALA2026067 | A | Metabolic stability in human NCI-H1703 cells assessed as formation of arylated GSH at 5 uM after 30 mins by LC/MS analysis | Homo sapiens | 1 | ALA2021824 | cell-based format | Scientific Literature | |
| 19. | ALA2026068 | A | Metabolic stability in human NCI-H1703 cells assessed as formation of arylated GSH at 5 uM after 60 mins by LC/MS analysis | Homo sapiens | 1 | ALA2021824 | cell-based format | Scientific Literature | |
| 20. | ALA2026069 | F | Antitumor activity against human NCI-H1703 cells xenografted in athymic NCr-nu/nu mouse at 20 umol/kg, ip 5 times a week for 4-weeks relative to control | Homo sapiens | 1 | ALA2021824 | organism-based format | Scientific Literature |
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