| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2049280 | F | Cytotoxicity against human NCI-H2228 cells after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA1942693 | F | Antitumor activity against human NCI-H2228 cells expressing EML4-ALK xenografted mouse model assessed as tumor growth inhibition at 20 mg/kg, po | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA971312 | F | Cytotoxicity against human NCI-H2228 cells assessed as fraction of viable cells after 72 hrs relative to control | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
| 4. | ALA1646585 | F | Growth inhibition of human NCI-H2228 cells assessed as ATP level after 96 hrs by CellTiter-Glo assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA1781785 | F | Antitumor activity against human NCI-H2228 cells expressing EML4-ALK xenografted in SCID mouse assessed as reduction of tumor volume administered as po qd for 11 days | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA1781787 | F | Antitumor activity against human NCI-H2228 cells expressing EML4-ALK xenografted in SCID mouse assessed as tumor regression at 0.2 to 20 mg/kg, po qd for 11 days | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA2363513 | F | SANGER: Inhibition of human NCI-H2228 cell growth in a cell viability assay. | Homo sapiens | 98 | cell-based format | Sanger Institute Genomics of Drug Sensitivity in Cancer | ||
| 8. | ALA2406422 | F | Antitumor activity against human NCI-H2228 cells expressing EML4-ALK fusion gene xenografted in rat assessed as tumor regression | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA2405335 | F | Antitumor activity against human NCI-H2228 cells xenografted in Rowett nude rat assessed as complete tumor regression at 25 mg/kg, po for 14 days measured 7 to 72 hrs post dosing relative to control | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA2405336 | F | Antitumor activity against human NCI-H2228 cells xenografted in Rowett nude rat assessed as tumor growth inhibition factor at 10 mg/kg, po for 14 days measured 7 to 72 hrs post dosing relative to control | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA2405337 | F | Antitumor activity against human NCI-H2228 cells xenografted in Rowett nude rat assessed as tumor growth inhibition factor at 5 mg/kg, po for 14 days measured 7 to 72 hrs post dosing relative to control | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA2405338 | F | Antitumor activity against human NCI-H2228 cells xenografted in po dosed Rowett nude rat assessed as tumor growth inhibition administered for 14 days measured 7 to 72 hrs post dosing | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA3129269 | F | Ratio of crizotinib IC50 to compound IC50 for human NCI-H2228 cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA3129278 | F | Inhibition of ALK-fusion driven cell proliferation in human NCI-H2228 cells after 72 hrs by CellTiter Glo assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA3413670 | F | Cytotoxicity against human NCI-H2228 cells assessed as cell viability after 72 hrs by MTS assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 16. | ALA3413671 | F | Antitumor activity against human NCI-H2228 cells xenografted in Rowett nude rat assessed as tumor growth inhibition at 36.24 mg/kg/day, po administered for 14 days measured on day 15 | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA3413672 | F | Antitumor activity against human NCI-H2228 cells xenografted in Rowett nude rat assessed as tumor growth inhibition at 38.28 mg/kg/day, po administered for 14 days measured on day 15 relative to vehicle-treated control | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA3413673 | F | Antitumor activity against human NCI-H2228 cells xenografted in Rowett nude rat assessed as tumor growth inhibition at 30 mg/kg/day, po administered for 14 days measured on day 15 | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA3607643 | F | Antiproliferative activity against human NCI-H2228 cells assessed as inhibition of cell proliferation incubated for 96 hrs by cell-titer-Glo assay | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
| 20. | ALA3607645 | F | Antitumor activity activity against human NCI-H2228 cells xenografted in Balb/c mouse EML4-ALK NSCLC model assessed as reduction in tumor growth at 3 to 30 mg/kg, po qd for 2 weeks | Homo sapiens | 1 | organism-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!