# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1168828 | B | Inhibition of CDKL5 at 1 uM | 6 | ALA1165965 | single protein format | Scientific Literature | ||
2. | ALA1174173 | B | Inhibition of CDKL5 at 10 uM | 2 | ALA1177794 | single protein format | Scientific Literature | ||
3. | ALA1244766 | B | Binding affinity to CDKL5 | 7 | ALA1240346 | single protein format | Scientific Literature | ||
4. | ALA1826944 | B | Activity of CDKL5 kinase at 1 uM | 1 | ALA1821651 | single protein format | Scientific Literature | ||
5. | ALA1908602 | B | Binding constant for CDKL5 kinase domain | 72 | ALA1908390 | single protein format | Scientific Literature | ||
6. | ALA2154886 | B | Binding affinity to CDKL5 | 1 | ALA2150858 | single protein format | Scientific Literature | ||
7. | ALA2209326 | B | Inhibition of CDKL5 assessed as residual activity at 10 uM relative to control | 1 | ALA2203081 | single protein format | Scientific Literature | ||
8. | ALA3112114 | B | Inhibition of CDKL5 (unknown origin) assessed as residual activity at 10 uM after 1 hr by qPCR analysis relative to control | Homo sapiens | 1 | ALA3108735 | single protein format | Scientific Literature | |
9. | ALA3991664 | B | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | Homo sapiens | 152 | ALA3991601 | subcellular format | Kuster lab chemical proteomics drug profiling | |
10. | ALA4025063 | B | Inhibition of wild-type human partial length CDKL5 (M1 to S337 residues) expressed in mammalian expression system assessed as residual activity at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4024706 | assay format | Scientific Literature | |
11. | ALA4043874 | B | Inhibition of wild-type human partial length CDKL5 (M1 to S337 residues) expressed in HEK293 cells assessed as residual activity at 1000 nM after 30 mins by Kinomescan method relative to control | Homo sapiens | 1 | ALA4043093 | cell-based format | Scientific Literature | |
12. | ALA4055032 | B | Inhibition of wild-type human partial length CDKL5 (M1 to S337 residues) expressed in mammalian expression system assessed as residual activity at 50 nM by Kinomescan method relative to control | Homo sapiens | 2 | ALA4052645 | assay format | Scientific Literature | |
13. | ALA4151446 | B | Inhibition of human CDKL5 expressed in mammalian expression system assessed as remaining enzyme activity at 10 uM by kinome scan assay | Homo sapiens | 3 | ALA4145671 | assay format | Scientific Literature | |
14. | ALA4156953 | B | Binding affinity to wild-type human partial length CDKL5 (M1 to S337 residues) expressed in mammalian expression system assessed as residual binding at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4152344 | assay format | Scientific Literature | |
15. | ALA4185732 | B | Binding affinity to wild-type human partial length CDKL5 (M1 to S337 residues) expressed in HEK293 cells at 1 uM by Kinomescan method relative to control | Homo sapiens | 2 | ALA4184148 | cell-based format | Scientific Literature | |
16. | ALA4230632 | B | Binding affinity to wild-type human partial length CDKL5 (M1 to S337 residues) expressed in mammalian expression system assessed as residual binding level at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4229344 | assay format | Scientific Literature | |
17. | ALA4264221 | B | Binding affinity to wild-type human partial length CDKL5 (M1 to S337 residues) expressed in mammalian expression system assessed as remaining unbound target protein level at 1000 nM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4261600 | assay format | Scientific Literature | |
18. | ALA4307736 | B | Binding affinity to wild-type human partial length CDKL5 (M1 to S337 residues) expressed in mammalian expression system assessed as residual binding level at 10 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4304811 | assay format | Scientific Literature | |
19. | ALA4333327 | B | Binding affinity to wild-type human partial length CDKL5 (M1 to S337 residues) expressed in mammalian expression system assessed as residual binding level at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4330132 | assay format | Scientific Literature | |
20. | ALA4357810 | B | Binding affinity to wild-type human partial length CDKL5 (M1 to S337 residues) expressed in mammalian expression system assessed as residual binding level at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4354843 | assay format | Scientific Literature |