| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1252890 | B | Induction of TRPM2 S-nitrosylation in HEK cells assessed as increase in Ca2+ level from extracellular space at 30 uM | Homo sapiens | 1 | ALA1250444 | cell-based format | Scientific Literature | |
| 2. | ALA3110967 | B | Partial antagonist activity at TRPM2 in human polymorphonuclear neutrophils assessed as reduction in fMLP-induced chemotaxis at 100 uM preincubated for 15 mins followed by fMLP-challenge by microscopic analysis | Homo sapiens | 1 | ALA3108672 | single protein format | Scientific Literature | |
| 3. | ALA3110968 | B | Partial antagonist activity at TRPM2 in human polymorphonuclear neutrophils assessed as reduction in A5 peptide-induced intracellular calcium accumulation at 100 uM preincubated for 15 mins followed by A5 peptide-challenge by fluorescence microscopic analysis relative to control | Homo sapiens | 1 | ALA3108672 | cell-based format | Scientific Literature | |
| 4. | ALA3111084 | B | Partial antagonist activity at TRPM2 in human polymorphonuclear neutrophils assessed as reduction in fMLP-induced intracellular calcium accumulation at 100 uM preincubated for 15 mins followed by fMLP-challenge by fluorescence microscopic analysis relative to control | Homo sapiens | 1 | ALA3108672 | cell-based format | Scientific Literature | |
| 5. | ALA3111085 | B | Antagonist activity at human TRPM2 expressed in HEK293 cells assessed as partial inhibition of ADPR-induced maximum outward potassium current at +15 mV by whole-cell patch-clamp electrophysiology | Homo sapiens | 1 | ALA3108672 | cell-based format | Scientific Literature | |
| 6. | ALA3111086 | B | Inhibition of TRPM2 (unknown origin) | Homo sapiens | 3 | ALA3108672 | single protein format | Scientific Literature | |
| 7. | ALA3111087 | B | Antagonist activity at human TRPM2 expressed in HEK293 cells assessed as inhibition of ADPR-induced maximum outward potassium current at 900 uM at +15 mV by whole-cell patch-clamp electrophysiology | Homo sapiens | 6 | ALA3108672 | cell-based format | Scientific Literature | |
| 8. | ALA3111088 | B | Antagonist activity at human TRPM2 expressed in HEK293 cells assessed as inhibition of ADPR-induced maximum outward potassium current at 100 uM at +15 mV by whole-cell patch-clamp electrophysiology | Homo sapiens | 9 | ALA3108672 | cell-based format | Scientific Literature | |
| 9. | ALA3111089 | B | Antagonist activity at human TRPM2 expressed in HEK293 cells assessed as inhibition of ADPR-induced maximum outward potassium current at +15 mV by whole-cell patch-clamp electrophysiology | Homo sapiens | 16 | ALA3108672 | cell-based format | Scientific Literature | |
| 10. | ALA3111090 | B | Inhibition of TRPM2 (unknown origin) expressed in HEK293 cells assessed as inhibition of ADP-ribose-induced current by patch clamp technique | Homo sapiens | 1 | ALA3108672 | cell-based format | Scientific Literature | |
| 11. | ALA3111091 | B | Inhibition of human TRPM2 expressed in HEK293 cells | Homo sapiens | 1 | ALA3108672 | cell-based format | Scientific Literature | |
| 12. | ALA3111092 | B | Inhibition of human TRPM2 expressed in HEK293 cells assessed as inhibition of H2O2-induced intracellular calcium level by patch clamp technique | Homo sapiens | 1 | ALA3108672 | cell-based format | Scientific Literature | |
| 13. | ALA3111093 | B | Inhibition of human TRPM2 expressed in HEK293 cells assessed as inhibition of ADP-ribose-induced current by patch clamp electrophysiology | Homo sapiens | 1 | ALA3108672 | cell-based format | Scientific Literature | |
| 14. | ALA3111094 | B | Inhibition of human recombinant TRPM2 | Homo sapiens | 3 | ALA3108672 | single protein format | Scientific Literature | |
| 15. | ALA3111095 | B | Activation of TRPM2 (unknown origin) | Homo sapiens | 1 | ALA3108672 | single protein format | Scientific Literature | |
| 16. | ALA3734573 | F | Inhibition of TRPM2 (unknown origin) expressed in HEK293 cells assessed as effect on agonist-induced Ca2+ changes | Homo sapiens | 1 | ALA3727350 | cell-based format | Patent Bioactivity Data | |
| 17. | ALA4134886 | B | Inhibition of human FLAG-tagged TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced intracellular calcium flux after 30 to 60 mins by whole cell patch clamp electrophysiology method | Homo sapiens | 1 | ALA4130479 | cell-based format | Scientific Literature | |
| 18. | ALA4134887 | B | Inhibition of human FLAG-tagged TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced intracellular calcium flux at 2 uM by whole cell patch clamp electrophysiology method | Homo sapiens | 1 | ALA4130479 | cell-based format | Scientific Literature | |
| 19. | ALA4134888 | B | Inhibition of human FLAG-tagged TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced intracellular calcium flux at 2 uM treated for 6 hrs followed by compound washout measured within 5 mins by whole cell patch clamp electrophysiology method | Homo sapiens | 1 | ALA4130479 | cell-based format | Scientific Literature | |
| 20. | ALA4134894 | B | Inhibition of human FLAG-tagged TRPM2 expressed in HEK293 cells assessed as reduction in H2O2-induced intracellular calcium flux pretreated for 30 secs followed by H2O2 addition measured for 120 secs by Fluo4-AM dye based fluorescence assay | Homo sapiens | 2 | ALA4130479 | cell-based format | Scientific Literature |
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