# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2162825 | B | Inhibition of human Hex A using 4-MU-GlcNAc as substrate after 10 mins by Lineweaver Burk plot analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
2. | ALA985859 | B | Activation of beta Hex A alpha G269S/c.1278insTACT mutant isolated from Tay-Sachs disease patient assessed as increase in HEX A activity relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
3. | ALA985860 | B | Activation of beta Hex A alpha IVS9 + 1G>A/IVS8-7G>A mutant isolated from Tay-Sachs disease patient assessed as increase in HEX A activity relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
4. | ALA985861 | B | Activation of beta Hex A alpha G269S/c.1278insTACT mutant isolated from Tay-Sachs disease patient assessed as increase in HEX A activity at 300 ug/ml relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
5. | ALA985862 | B | Activation of beta Hex A alpha IVS9 + 1G>A/IVS8-7G>A mutant isolated from Tay-Sachs disease patient assessed as increase in HEX A activity at 300 ug/ml relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
6. | ALA985863 | B | Activation of beta Hex A alphaG269S mutant isolated from Tay-Sachs disease patient assessed as increase in activator-[3H]GM2 complex hydrolysis at 3 ug/ml relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
7. | ALA986740 | B | Activation of beta Hex A alphaG269S mutant isolated from Tay-Sachs disease patient assessed as increase in 4-methylumbelliferyl-7-(6-sulfo-2-acetamido-2-deoxy)-beta-D-glucopyranoside hydrolysis at 3 ug/ml relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
8. | ALA986750 | B | Pharmacological chaperone effect on beta Hex A beta-G353R/IVS12-26G>A mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity at 3 ug/ml by immunoselection assay relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
9. | ALA986751 | B | Pharmacological chaperone effect on beta Hex A beta-G353R/IVS12-26G>A mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity at 300 mg/ml by immunoselection assay relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
10. | ALA986752 | B | Pharmacological chaperone effect on beta Hex A beta-G353R/IVS12-26G>A mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX S activity at 3 ug/ml by immunoselection assay relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
11. | ALA986753 | B | Pharmacological chaperone effect on beta Hex A beta-G353R/IVS12-26G>A mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX S activity at 300 mg/ml by immunoselection assay relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
12. | ALA983114 | B | Pharmacological chaperone effect on beta Hex A beta-R505Q/IVS11 + 5G>A mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity at 3 ug/ml by immunoselection assay relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
13. | ALA983115 | B | Pharmacological chaperone effect on beta Hex A beta-R505Q/IVS11 + 5G>A mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity at 300 mg/ml by immunoselection assay relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
14. | ALA983116 | B | Pharmacological chaperone effect on beta Hex A beta-R505Q/IVS11 + 5G>A mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX S activity at 3 ug/ml by immunoselection assay relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
15. | ALA983117 | B | Pharmacological chaperone effect on beta Hex A beta-R505Q/IVS11 + 5G>A mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX S activity at 300 mg/ml by immunoselection assay relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
16. | ALA983126 | B | Pharmacological chaperone effect on beta Hex A alpha G269S/c.1278ins TACT mutant in fibroblasts from Tay-Sachs disease patient assessed as increase in HEX A activity relative to control | Homo sapiens | 2 | single protein format | Scientific Literature | ||
17. | ALA983127 | B | Pharmacological chaperone effect on beta Hex A alpha G269S/IV6 + 1G>A mutant in fibroblasts from Tay-Sachs disease patient assessed as increase in HEX A activity relative to control | Homo sapiens | 2 | single protein format | Scientific Literature | ||
18. | ALA983128 | B | Pharmacological chaperone effect on beta Hex A alpha IVS9 + 1G>A/IVS8-7G>A mutant in fibroblasts from Tay-Sachs disease patient assessed as increase in HEX A activity relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
19. | ALA983129 | B | Activation of on beta Hex A beta R505Q/IVS11 + 5G>A mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity relative to control | Homo sapiens | 2 | single protein format | Scientific Literature | ||
20. | ALA983132 | B | Pharmacological chaperone effect on beta Hex A beta G353R/IVS12-26G>A mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity relative to control | Homo sapiens | 2 | single protein format | Scientific Literature |