# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1260363 | F | Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level | Mus musculus | 31 | ALA1255552 | cell-based format | Scientific Literature | |
2. | ALA2187733 | F | Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay | Mus musculus | 28 | ALA2177042 | cell-based format | Scientific Literature | |
3. | ALA2340400 | F | Agonist activity at mouse TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay | Mus musculus | 1 | ALA2331085 | cell-based format | Scientific Literature | |
4. | ALA2410508 | B | Agonist activity at recombinant mouse GPBAR1 expressed in CHO cells relative to lithocholic acid | Mus musculus | 19 | ALA2406956 | cell-based format | Scientific Literature | |
5. | ALA2410509 | B | Agonist activity at recombinant mouse GPBAR1 expressed in CHO cells | Mus musculus | 20 | ALA2406956 | cell-based format | Scientific Literature | |
6. | ALA2439680 | F | Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay relative to control | Mus musculus | 14 | ALA2434932 | cell-based format | Scientific Literature | |
7. | ALA2439681 | F | Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay | Mus musculus | 14 | ALA2434932 | cell-based format | Scientific Literature | |
8. | ALA3239421 | F | Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay | Mus musculus | 42 | ALA3232835 | cell-based format | Scientific Literature | |
9. | ALA3239425 | B | Agonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nM | Mus musculus | 2 | ALA3232835 | cell-based format | Scientific Literature | |
10. | ALA3239426 | B | Agonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nM relative to N-(3,5-dichlorophenyl)-N-(1-(2-methoxyphenyl)ethyl)-3-methylisonicotinamide | Mus musculus | 2 | ALA3232835 | cell-based format | Scientific Literature | |
11. | ALA3239495 | F | Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay relative to control | Mus musculus | 42 | ALA3232835 | cell-based format | Scientific Literature | |
12. | ALA3269770 | F | Agonist activity at GP-BAR1 in mouse GLUTag cells assessed as increase in intracellular cAMP level | Mus musculus | 3 | ALA3259647 | cell-based format | Scientific Literature | |
13. | ALA3269771 | B | Agonist activity at GP-BAR1 in mouse GLUTag cells assessed as increase in GLP-1 release | Mus musculus | 3 | ALA3259647 | cell-based format | Scientific Literature | |
14. | ALA3292681 | F | Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay | Mus musculus | 38 | ALA3286383 | cell-based format | Scientific Literature | |
15. | ALA3376497 | B | Agonist activity at GP-BAR1 in mouse GLUTag cells assessed as increase in pro-glucagon mRNA expression at 10 uM by RT-PCR method | Mus musculus | 3 | ALA3351323 | cell-based format | Scientific Literature | |
16. | ALA3424621 | F | Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay | Mus musculus | 12 | ALA3421628 | cell-based format | Scientific Literature | |
17. | ALA3796548 | B | Agonist activity at mouse TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay | Mus musculus | 1 | ALA3792350 | cell-based format | Scientific Literature | |
18. | ALA4000086 | F | Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method | Mus musculus | 45 | ALA3997854 | cell-based format | Scientific Literature | |
19. | ALA4010935 | F | Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method | Mus musculus | 16 | ALA4007482 | cell-based format | Scientific Literature | |
20. | ALA4032768 | A | Agonist activity at mouse TGR5 | Mus musculus | 4 | ALA4028903 | single protein format | Scientific Literature |