| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1267179 | B | Displacement of IWP-PB from porcn in HEK293 lysate by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 2. | ALA1267180 | B | Inhibition of porcn in HEK293 cell lysate by Western blot analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 3. | ALA1267181 | B | Inhibition of porcn-mediated Lrp6 maturation in human DLD1 lysate by detergent solubility fractionation assessed as [3H]palmitate incorporation at 2.5 uM by autoradiography method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 4. | ALA1267182 | B | Inhibition of porcn-mediated Shh palmitoylation in human DLD1 lysate by detergent solubility fractionation assessed as [3H]palmitate incorporation at 2.5 uM by autoradiography method | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 5. | ALA2330992 | B | Inhibition of porcupine-mediated phosphorylation of dishevelled 2 in HEK293 cells at 2.5 uM | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA3626166 | B | Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as reduction in Wnt ligand-driven LEF/TCF-dependent transcriptional activity | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 7. | ALA3626167 | B | Inhibition of porcupine (unknown origin) expressed in HEK293T cells transfected with pLinbin- Wnt3A plasmid assessed as inhibition of Wnt3A secretion at 0.1 uM incubated for 48 hrs by Western blotting method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 8. | ALA3626180 | B | Inhibition of porcupine (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA3626182 | B | Potency index, ratio of IC50 for LGK974 to IC50 for test compound for inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with HEK293 STF cells by STF reporter gene based paracrine cellular reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA3635400 | B | Inhibition of porcupine activity (unknown origin) expressed in human HT1080 cells assessed as suppression of Wnt3A-mediated super top flash activity by STF luciferase assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 11. | ALA3635401 | B | Inhibition of porcupine in human HEK293 cells assessed as reduction in Wnt secretion by measuring suppression of beta-catenin reporter activity after 24 hrs by STF reporter assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA3635405 | B | Inhibition of porcupine in human HEK293 cells by STF reporter assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA3635406 | B | Binding affinity to porcupine (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 14. | ALA3762381 | B | Inhibition of porcupine (unknown origin) in HEK293T cells transfected with pLibin-WNT3A plasmid assessed as reduction in Wnt3A secretion into cell culture medium at 0.1 uM after 48 hrs by Western blot technique | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA3861542 | B | Inhibition of porcupine in HEK293T cells transfected with pLibin-WNT3A plasmid assessed as reduction in Wnt3A secretion into cell culture medium at 0.1 uM after 48 hrs by Western blot method | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 16. | ALA3870975 | B | Inhibition of porcupine-mediated phosphorylation of dishevelled 2/3 in human HeLa cells at 1 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA3870976 | B | Inhibition of porcupine-mediated phosphorylation of LRP6 in human HeLa cells at 1 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4000296 | B | Inhibition of porcupine (unknown origin) expressed in HEK293-STF3A cells assessed as inhibition of Wnt signaling by measuring decrease in beta-catenin-mediated transcriptional activity after 24 hrs by Steady-Glo luciferase assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 19. | ALA4000305 | B | Inhibition of PORCN-mediated V5-tagged Wnt3A palmitoylation in human HeLa cells at 100 nM measured after over night incubation by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 20. | ALA4040030 | B | Inhibition of porcupine (unknown origin) | Homo sapiens | 3 | single protein format | Scientific Literature |
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