# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1176173 | B | Binding affinity to HSC70 EEVD domain by mass spectroscopy | 1 | ALA1177696 | single protein format | Scientific Literature | ||
2. | ALA1226138 | B | Induction of annexin-2-mediated cytotoxicity in human MCF10A cells assessed as cell morphology at 4 uM after 2 hrs by scanning electron microscopy | Homo sapiens | 2 | ALA1221176 | cell-based format | Scientific Literature | |
3. | ALA1273373 | B | Binding affinity to human Hsc70 by isothermal calorimetry assay | Homo sapiens | 1 | ALA1268867 | single protein format | Scientific Literature | |
4. | ALA1273376 | B | Binding affinity to Hsp70 nucleotide binding domain in human BT474 cells | Homo sapiens | 1 | ALA1268867 | cell-based format | Scientific Literature | |
5. | ALA1613796 | B | PUBCHEM_BIOASSAY: High Throughput Screening Assay for Hsc70 Inhibitors. (Class of assay: confirmatory) | Homo sapiens | 32 | ALA1201862 | single protein format | PubChem BioAssays | |
6. | ALA1614143 | B | PUBCHEM_BIOASSAY: In Vitro Hsc70 Dose Response Fluorescence Polarization Assay. (Class of assay: confirmatory) [Related pubchem assays: 1072 ] | Homo sapiens | 53 | ALA1201862 | single protein format | PubChem BioAssays | |
7. | ALA2444023 | B | Displacement of N6-(6-amino)hexyl-ATP ATTO-590-ATP from HSC70 (unknown origin) after 18 hrs by fluorescence polarization assay | Homo sapiens | 4 | ALA2439976 | single protein format | Scientific Literature | |
8. | ALA3095088 | B | Binding affinity to human HSC70 after 3 hrs by ELISA | Homo sapiens | 14 | ALA3091336 | single protein format | Scientific Literature | |
9. | ALA3375010 | B | Inhibition of HSC70 (unknown origin) | Homo sapiens | 5 | ALA3352169 | single protein format | Scientific Literature | |
10. | ALA3825930 | B | Binding affinity to human truncated HSC70 NBD (1 to 381 residues) by SPR analysis | Homo sapiens | 20 | ALA3822412 | single protein format | Scientific Literature | |
11. | ALA4137421 | B | Binding affinity to human HSC70 after 2 hrs by fluorescence shift assay | Homo sapiens | 2 | ALA4130633 | single protein format | Scientific Literature | |
12. | ALA4137422 | B | Binding affinity to human HSC70 Y149A mutant after 2 hrs by fluorescence shift assay | Homo sapiens | 1 | ALA4130633 | single protein format | Scientific Literature | |
13. | ALA4137423 | B | Binding affinity to human HSC70 Y149W mutant after 2 hrs by fluorescence shift assay | Homo sapiens | 1 | ALA4130633 | single protein format | Scientific Literature | |
14. | ALA4137424 | B | Binding affinity to human HSC70 T222A mutant after 2 hrs by fluorescence shift assay | Homo sapiens | 1 | ALA4130633 | single protein format | Scientific Literature | |
15. | ALA4137425 | B | Binding affinity to human HSC70 H227A mutant after 2 hrs by fluorescence shift assay | Homo sapiens | 1 | ALA4130633 | single protein format | Scientific Literature | |
16. | ALA4137426 | B | Binding affinity to human HSC70 L228A mutant after 2 hrs by fluorescence shift assay | Homo sapiens | 1 | ALA4130633 | single protein format | Scientific Literature | |
17. | ALA4220472 | B | Allosteric regulation of recombinant HSC70 (unknown origin) ATPase activity assessed as increase in ADP production at 10 uM after 10 mins in presence of HCV wild type poly U/UC RNA by HPLC analysis | Homo sapiens | 11 | ALA4219061 | single protein format | Scientific Literature | |
18. | ALA4220473 | B | Induction of HSC70 chaperone activity in human Huh-luc/neo-ET cells assessed as reduction in HCV RNA NS5A protein expression at 6 nM after 24 hrs | Homo sapiens | 1 | ALA4219061 | cell-based format | Scientific Literature | |
19. | ALA4220474 | B | Displacement of biotinylated-rac-cryptopleurine from recombinant HSC70 (unknown origin) expressed in human Huh-luc/neo-ET cells by Western blot analysis | Homo sapiens | 4 | ALA4219061 | cell-based format | Scientific Literature | |
20. | ALA4220475 | B | Induction of HSC70 (unknown origin) chaperone activity assessed as reactivation of guanidine-denatured luciferase by luciferase reporter gene assay | Homo sapiens | 2 | ALA4219061 | single protein format | Scientific Literature |