# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3578942 | Binding | Inhibition of PRMT6 (unknown origin) | Homo sapiens | 1 | ALA3576805 | single protein format | Scientific Literature | |
2. | ALA3591482 | Binding | Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SAM and peptide mix | Homo sapiens | 21 | ALA3588846 | cell-based format | Scientific Literature | |
3. | ALA3591656 | Binding | Inhibition of his-tagged PRMT6 (unknown origin) expressed in human A375 cells assessed as reduction in H3R2 methylation at 0.01 to 20 uM incubated for 48 hrs by Western blot method | Homo sapiens | 2 | ALA3588846 | cell-based format | Scientific Literature | |
4. | ALA3591657 | Binding | Inhibition of his-tagged PRMT6 (unknown origin) expressed in human A375 cells assessed as reduction in H3R2 methylation up to 20 uM incubated for 48 hrs by Western blot method | Homo sapiens | 1 | ALA3588846 | cell-based format | Scientific Literature | |
5. | ALA3592408 | Binding | Inhibition of PRMT6 (unknown origin) assessed as incorporation of tritium labeled methyl group from [3H]-SAM to substrate at 1 uM after 1 hr by scintillation proximity assay relative to control | Homo sapiens | 1 | ALA3588844 | single protein format | Scientific Literature | |
6. | ALA3636209 | Binding | Inhibition of PRMT6 (unknown origin) using biotinylated histone H4-derived peptide as substrate after 60 mins by AlphaLISA assay | Homo sapiens | 1 | ALA3632463 | single protein format | Scientific Literature | |
7. | ALA3784078 | Binding | Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-S-adenosylmethionine by scintillation proximity assay | Homo sapiens | 17 | ALA3779843 | cell-based format | Scientific Literature | |
8. | ALA3784633 | Binding | Inhibition of PRMT6 L267E mutant (unknown origin) using 24 residues of biotin labelled histone4 substrate and tritiated 3H-S-adenosylmethionine by scintillation proximity assay | Homo sapiens | 1 | ALA3779843 | assay format | Scientific Literature | |
9. | ALA3784634 | Binding | Inhibition of FLAG-tagged human PRMT6 expressed in HEK293 cells assessed as reduction in H3R2 global methylation incubated for 20 hrs by Western blot method | Homo sapiens | 1 | ALA3779843 | cell-based format | Scientific Literature | |
10. | ALA3784635 | Binding | Binding affinity to Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells by ITC method | Homo sapiens | 1 | ALA3779843 | cell-based format | Scientific Literature | |
11. | ALA3784638 | Binding | Non-competitive inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-S-adenosylmethionine by scintillation proximity assay | Homo sapiens | 2 | ALA3779843 | cell-based format | Scientific Literature | |
12. | ALA3803129 | Binding | Inhibition of PRMT6 (unknown origin) at 10 uM relative to control | Homo sapiens | 2 | ALA3797202 | single protein format | Scientific Literature | |
13. | ALA3821901 | Binding | Inhibition of PRMT6 (unknown origin) at 1 to 50 uM by scintillation proximity assay | Homo sapiens | 1 | ALA3817823 | single protein format | Scientific Literature | |
14. | ALA1273736 | Binding | Inhibition of His6x-tagged PRMT6-mediated arginine methylation expressed in Escherichia coli BL21 (DE3) using H3(1-31) peptide and [14C]-SAM by scintillation counting | 1 | ALA1268868 | assay format | Scientific Literature | ||
15. | ALA2050394 | Binding | Inhibition of His6X-tagged PRMT6 expressed in Escherichia coli BL21(DE3) cells using [14C]-S-adenosyl-L-methionine and histone H4 peptide after 8 mins by scintillation counting | 1 | ALA2046392 | cell-based format | Scientific Literature | ||
16. | ALA2182455 | Binding | Inhibition of recombinant PRMT6 using histone H3 as substrate at 50 uM and [3H]-SAM after 90 mins by scintillation counting | 2 | ALA2176902 | single protein format | Scientific Literature | ||
17. | ALA3111897 | Binding | Inhibition of PRMT6 (unknown origin)-mediated incorporation of methyl group from [3H]-SAM into peptide substrate up to 50 uM by scintillation proximity assay | Homo sapiens | 1 | ALA3108684 | single protein format | Scientific Literature | |
18. | ALA3226872 | Binding | Activity at 100 to 400 nM of PRMT6 (unknown origin) assessed as increase of Vmax up to 200 uM relative to control | Homo sapiens | 1 | ALA3217521 | single protein format | Scientific Literature | |
19. | ALA3226873 | Binding | Activity at 50 to 800 nM of PRMT6 (unknown origin) assessed as increase of Vmax up to 200 uM relative to control | Homo sapiens | 1 | ALA3217521 | single protein format | Scientific Literature | |
20. | ALA3226874 | Binding | Activity at 50 to 800 nM of PRMT6 (unknown origin) assessed as increase of Km up to 200 uM relative to control | Homo sapiens | 1 | ALA3217521 | single protein format | Scientific Literature |