| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1287360 | B | Inhibition of human UGT1A1 at 10 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 2. | ALA1291156 | B | Displacement of radiolabeled scopoletin from UGT1A1 at 1 to 3 uM | 1 | single protein format | Scientific Literature | |||
| 3. | ALA1743324 | A | Substrate of human UDP-glucuronosyltransferase UGT1A1 | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 4. | ALA1908080 | A | Specific activity of expressed human recombinant UGT1A1 | Homo sapiens | 167 | single protein format | Scientific Literature | ||
| 5. | ALA1908113 | B | Drug glucuronidation reaction catalyzed by human recombinant UGT1A1 | Homo sapiens | 15 | single protein format | Scientific Literature | ||
| 6. | ALA1908125 | B | Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A1 | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 7. | ALA2046057 | A | Activity at UGT1A1 in human liver microsomes at 50 uM incubated for 3 mins prior to NADPH-addition measured up to 120 mins by HPLC/UV analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 8. | ALA3398972 | A | Drug metabolism assessed as UGT1A1-mediated compound glucuronidation in pooled mixed-gender human liver microsomes at 50 uM preincubated at 37 degC for 3 mins before UDPGA addition by HPLC method | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 9. | ALA3398977 | A | Activation of UGT1A1 in pooled mixed-gender human liver microsomes at 50 uM preincubated at 37 degC for 3 mins before UDPGA addition by HPLC method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 10. | ALA3398991 | A | Inhibition of of UGT1A1 in pooled mixed-gender human liver microsomes using 4-methylumbelliferone substrate by HPLC method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 11. | ALA3540850 | A | Activity of human UGT1A1 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated (2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(5-(4-((6-methoxy-1-methyl-1H-benzo[d]imidazol-2-yl)methoxy)benzyl)-2,4-dioxothiazolidin-3-yl)tetrahydro-2H-pyran-2-carboxylic acid formation at 20 uM after 4 hrs by radio-HPLC/LC-MS/MS analysis in presence of UDPGA | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 12. | ALA3541776 | A | Drug metabolism in UDPGA-fortified human liver microsomes assessed as UGT1A1-mediated DTG glucuronide M2 ((2S,3S,4S,5R,6S)-6-((4R,12aS)-9-(2,4-difluorobenzylcarbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazin-7-yloxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid) formation after 120 mins by radio-HPLC analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 13. | ALA3541777 | A | Drug metabolism in UDPGA-fortified human liver microsomes assessed as UGT1A1-mediated DTG glucuronide M2 ((2S,3S,4S,5R,6S)-6-((4R,12aS)-9-(2,4-difluorobenzylcarbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazin-7-yloxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid) formation after 120 mins measured per mg of protein by radio-HPLC analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 14. | ALA3541778 | A | Drug metabolism in UDPGA-fortified human liver microsomes assessed as intrinsic clearance for UGT1A1-mediated DTG glucuronide M2 ((2S,3S,4S,5R,6S)-6-((4R,12aS)-9-(2,4-difluorobenzylcarbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazin-7-yloxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid) formation after 120 mins measured per mg of protein by radio-HPLC analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 15. | ALA3541779 | A | Drug metabolism assessed as human recombinant UGT1A1-mediated DTG glucuronide M2 ((2S,3S,4S,5R,6S)-6-((4R,12aS)-9-(2,4-difluorobenzylcarbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazin-7-yloxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid) formation after 120 mins by radio-HPLC analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 16. | ALA3538588 | A | Drug metabolism in human intestinal microsomes assessed as UGT1A1-mediated unbound intrinsic glucuronidation clearance at 1 uM after 30 to 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 17. | ALA3538595 | A | Ratio of UGT1A1-mediated unbound intrinsic glucuronidation clearance in human kidney microsomes to UGT1A1-mediated unbound intrinsic glucuronidation clearance in human liver microsomes at 1 uM | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 18. | ALA3539907 | A | Drug metabolism assessed as recombinant human UGT1A1 assessed as O-glucuronidation at 100 uM incubated for 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 19. | ALA3539917 | A | Drug metabolism assessed as recombinant human UGT1A1 assessed as N-glucuronidation at 100 uM incubated for 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 20. | ALA3539617 | A | Drug metabolism assessed as human recombinant UGT1A1-mediated DTG glucuronide M2 ((2S,3S,4S,5R,6S)-6-((4R,12aS)-9-(2,4-difluorobenzylcarbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazin-7-yloxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid) formation after 120 mins measured per mg of protein by radio-HPLC analysis | Homo sapiens | 1 | single protein format | Scientific Literature |
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