# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1293139 | Binding | Inhibition of trophozoite stage of Plasmodium falciparum 3D7 HDAC1 in infected-human erythrocytes assessed as histone H4 hyperacetylation at 20 to 100 nM after 3.5 hrs by Western blot analysis | Plasmodium falciparum 3D7 | 4 | ALA1287677 | cell-based format | Scientific Literature | |
2. | ALA1293140 | Binding | Inhibition of Plasmodium falciparum 3D7 HDAC1 in infected-human erythrocytes assessed as histone H4 hyperacetylation after 1.5 hrs by SDS-PAGE analysis | Plasmodium falciparum 3D7 | 2 | ALA1287677 | cell-based format | Scientific Literature | |
3. | ALA1637563 | Binding | Inhibition of Plasmodium falciparum 3D7 histone deacetylase infected in human erythrocytes assessed as alteration of histone H3 acetylation at 100 nM after 3.5 hrs by SDS-PAGE | Plasmodium falciparum 3D7 | 1 | ALA1629555 | cell-based format | Scientific Literature | |
4. | ALA1637564 | Binding | Inhibition of Plasmodium falciparum 3D7 histone deacetylase infected in human erythrocytes assessed as alteration of histone H3 acetylation at 1.8 to 1000 nM after 3.5 hrs by SDS-PAGE | Plasmodium falciparum 3D7 | 1 | ALA1629555 | cell-based format | Scientific Literature | |
5. | ALA1637566 | Binding | Inhibition of Plasmodium falciparum 3D7 histone deacetylase infected in human erythrocytes assessed as alteration of histone H3 acetylation after 3.5 hrs by SDS-PAGE | Plasmodium falciparum 3D7 | 2 | ALA1629555 | cell-based format | Scientific Literature | |
6. | ALA4268535 | Binding | Inhibition of HDAC in synchronized trophozoite stage Plasmodium falciparum 3D7 infected in human erythrocytes assessed as increase in acetylated H4 level at 5 times IC50 after 3 hrs by Western blot analysis relative to control | Plasmodium falciparum 3D7 | 12 | ALA4265952 | cell-based format | Scientific Literature | |
7. | ALA4268536 | Binding | Inhibition of HDAC in synchronized trophozoite stage Plasmodium falciparum 3D7 infected in human erythrocytes assessed as increase in acetylated H2B/H2Bv level at 5 times IC50 after 3 hrs by Western blot analysis relative to control | Plasmodium falciparum 3D7 | 1 | ALA4265952 | cell-based format | Scientific Literature | |
8. | ALA4268537 | Binding | Inhibition of HDAC in synchronized trophozoite stage Plasmodium falciparum 3D7 infected in human erythrocytes assessed as increase in acetylated H2A.Z level at 5 times IC50 after 3 hrs by Western blot analysis relative to control | Plasmodium falciparum 3D7 | 1 | ALA4265952 | cell-based format | Scientific Literature |