| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1738678 | F | PUBCHEM_BIOASSAY: SAR analysis of compounds that inhibit NOD2 - Set 3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1579, AID1848, AID1849, AID1852, AID2334, AID2335, AID2475] | Homo sapiens | 39 | ALA1201862 | assay format | PubChem BioAssays | |
| 2. | ALA1614247 | F | PUBCHEM_BIOASSAY: uHTS luminescence assay for the identification of compounds that inhibit NOD2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1575, AID1578, AID1579, AID1848, AID1849, AID1852, AID2001, AID2260, AID2264, AID2334, AID2335, AID2337, AID2466, AID2475, AID2485, AID2503, AID2793, AID2798, AID2799] | Homo sapiens | 327 | ALA1201862 | assay format | PubChem BioAssays | |
| 3. | ALA1738575 | F | PUBCHEM_BIOASSAY: SAR analysis of compounds that inhibit NOD2 revised. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1579, AID1848, AID1849, AID1852, AID2469, AID2475, AID2799, AID2800] | Homo sapiens | 131 | ALA1201862 | assay format | PubChem BioAssays | |
| 4. | ALA1737871 | F | PUBCHEM_BIOASSAY: SAR analysis of compounds that inhibit NOD2 - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1579, AID1848, AID1849, AID1852, AID2334, AID2335, AID2799] | Homo sapiens | 20 | ALA1201862 | assay format | PubChem BioAssays | |
| 5. | ALA1780350 | B | Activation of NOD2 expressed in HEK293 cells assessed as increase in IL8 secretion measured at 0.01 to 0.7 uM after 18 hrs by ELISA | 12 | ALA1777793 | cell-based format | Scientific Literature | ||
| 6. | ALA2020291 | B | Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter gene assay | Homo sapiens | 68 | ALA2016464 | cell-based format | Scientific Literature | |
| 7. | ALA2020297 | B | Inhibition of NOD-2 in human MCF7 cells assessed as inhibition of MDP-induced IL8 secretion at 0.25 to 5 uM by ELISA | Homo sapiens | 1 | ALA2016464 | cell-based format | Scientific Literature | |
| 8. | ALA2166309 | F | Agonist activity at human Nod2 expressed in HEK293-blue cells assessed as increase in NF-kappaB transcriptional activity at 20 uM incubated for 18 hrs using quanti blue assay based SEAP reporter gene assay | Homo sapiens | 8 | ALA2163344 | cell-based format | Scientific Literature | |
| 9. | ALA2422057 | B | Antagonist activity at NOD2 (unknown origin) | Homo sapiens | 4 | ALA2417394 | single protein format | Scientific Literature | |
| 10. | ALA2423797 | B | Modulation of NOD2 (unknown origin) | Homo sapiens | 28 | ALA2417394 | single protein format | Scientific Literature | |
| 11. | ALA3363924 | B | Inhibition of NOD2 (unknown origin) expressed in HEK293T cells coexpressing NF-kappaB driven luciferase reporter gene by HTS primary assay | Homo sapiens | 13 | ALA3352342 | cell-based format | Scientific Literature | |
| 12. | ALA3365540 | B | Agonist activity at human NOD2 stably expressed in HEK293 cells co-expressing secreted alkaline phosphatase assessed as NF-kappaB induction by liquid handler-assisted reporter gene assay | Homo sapiens | 33 | ALA3352666 | cell-based format | Scientific Literature | |
| 13. | ALA3361799 | B | Antagonist activity at human NOD2 stably expressed in HEK293 cells co-expressing secreted alkaline phosphatase assessed as NF-kappaB induction by liquid handler-assisted reporter gene assay | Homo sapiens | 6 | ALA3352666 | cell-based format | Scientific Literature | |
| 14. | ALA3803966 | B | Agonist activity at NOD2 receptor (unknown origin) expressed in HEK-Blue cells assessed as NF-kappaB transcriptional activity at 20 uM after 18 hrs by secreted embryonic alkaline phosphatase reporter gene assay relative to untreated control | Homo sapiens | 20 | ALA3797113 | cell-based format | Scientific Literature | |
| 15. | ALA3803968 | B | Agonist activity at NOD2 receptor (unknown origin) expressed in HEK-Blue cells assessed as NF-kappaB transcriptional activity after 18 hrs by secreted embryonic alkaline phosphatase reporter gene assay | Homo sapiens | 2 | ALA3797113 | cell-based format | Scientific Literature | |
| 16. | ALA3825656 | B | Activation of NOD2 in human monocytes assessed as inhibition of MDP-stimulated TNF-alpha production preincubated for 30 mins prior to MDP stimulation measured after 6 hrs by immunoassay | Homo sapiens | 1 | ALA3822396 | cell-based format | Scientific Literature | |
| 17. | ALA3993592 | B | Inhibition of MDP-induced human NOD2 signaling expressed in HEK-Blue cells preincubated for 3 hrs followed by MDP-stimulation for 20 hrs by spectrophotometry based SEAP reporter gene assay | Homo sapiens | 4 | ALA3992526 | cell-based format | Scientific Literature | |
| 18. | ALA3993593 | B | Activation of human NOD2 signaling expressed in HEK-Blue cells incubated for 3 hrs by spectrophotometry based SEAP reporter gene assay | Homo sapiens | 1 | ALA3992526 | cell-based format | Scientific Literature | |
| 19. | ALA3993595 | B | Inhibition of NOD2 signaling in human PBMC derived macrophages assessed as inhibition of MDP-induced IL-6 mRNA expression at 1 to 10 uM preincubated for 1 hr followed by MDP-stimulation for 90 mins by RT-PCR method | Homo sapiens | 1 | ALA3992526 | assay format | Scientific Literature | |
| 20. | ALA3993596 | B | Inhibition of MDP-stimulated human NOD2 activation expressed in HEK-Blue cells assessed as reduction in NOD2-mediated MAPK signaling by measuring decrease in phosphorylated p38 level preincubated for 1 hr followed by MDP-stimulation for 1 hr by Western blot method | Homo sapiens | 1 | ALA3992526 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!