| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1964067 | F | PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators: Hit Validation Using Renilla Luciferase Read-Out. (Class of assay: confirmatory) | 46 | assay format | PubChem BioAssays | |||
| 2. | ALA1614342 | F | PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) | Homo sapiens | 18,552 | assay format | PubChem BioAssays | ||
| 3. | ALA1738174 | F | PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators: Initial hit validation from the primary screen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485313, AID485315] | Homo sapiens | 93 | assay format | PubChem BioAssays | ||
| 4. | ALA2328534 | B | Binding affinity to human NPC1 expressed in LE/LY membrane of CHO cells at 25 uM by immunoblotting | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA2423075 | B | Binding affinity to NPC1 (unknown origin) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 6. | ALA3215230 | F | PubChem BioAssay. qHTS Assay for NPC1 Promoter Activators: Hit Validation Using Firefly Luciferase Read-Out for NPC1. (Class of assay: confirmatory) | 87 | assay format | PubChem BioAssays | |||
| 7. | ALA3214786 | F | PubChem BioAssay. qHTS Assay for NPC1 Promoter Activators: Hit Validation Using Renila Luciferase Read-Out for NPC1. (Class of assay: confirmatory) | 68 | assay format | PubChem BioAssays | |||
| 8. | ALA4021718 | B | Chaperone activity at FLAG/GFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as increase in localization of protein mutant in late endosomes after 24 hrs by Hoechst 33342 staining based fluorescence microscopic analysis | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
| 9. | ALA4021719 | B | Chaperone activity at FLAG/GFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as increase in localization of protein mutant in late endosomes at 10 uM after 24 hrs by Hoechst 33342 staining based fluorescence microscopic analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4021721 | B | Stabilization of FLAG/GFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as up regulation of NPC1 I1061T mutant expression after 24 hrs by Hoechst 33342 staining based fluorescence microscopic analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4021723 | B | Chaperone activity at FLAG/GFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as increase in localization of protein mutant in late endosomes at 30 uM after 24 hrs by Hoechst 33342 staining based fluorescence microscopic analysis | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
| 12. | ALA4021726 | B | Chaperone activity at FLAG/GFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as increase in localization of protein mutant in late endosomes at 1 uM after 24 hrs by Hoechst 33342 staining based fluorescence microscopic analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4049320 | B | Inhibition of NPC1 in human fibroblasts assessed as increase in cholesterol accumulation after 24 hrs by filipin staining-based assay | Homo sapiens | 10 | single protein format | Scientific Literature | ||
| 14. | ALA4261455 | B | Binding affinity to NPC1 in HUVEC assessed as increase in cholesterol accumulation in late endosome/lysosome at 0.2 uM after 14 hrs by filipin staining-based confocal microscopy | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 15. | ALA4341441 | B | Binding affinity to NPC1 in human A549 cells lysates grown on SILAC media at 10 uM incubated for 1 hr by LC-MS/MS analysis relative to untreated control | Homo sapiens | 1 | subcellular format | Scientific Literature | ||
| 16. | ALA4618803 | B | Inhibition of NPC1 in HUVEC cells assessed as accumulation of cholesterol in perinuclear structure at 0.2 uM incubated for 24 hrs by filipin staining based confocal microscopy analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 17. | ALA4737345 | B | Inhibition of NPC1 in human HeLa cells assessed as increase in cholesterol accumulation in subcellular localization at 1 uM incubated for 24 hrs by filipin-staining based immunofluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 18. | ALA4737346 | B | Inhibition of NPC1 in human HeLa cells assessed as increase in cholesterol accumulation in subcellular localization at 5 uM incubated for 24 hrs by filipin-staining based immunofluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature |
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