| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1613855 | F | PUBCHEM_BIOASSAY: Late stage results from the probe development effort to identify inhibitors of the protein methylesterase PME-1: Gel-based Activity-Based Protein Profiling (ABPP) IC50: Purified enzyme. (Class of assay: confirmatory) [Related pubchem assays: 2143 (Summary AID (PME-1 inhibitors)), 2130 (PME-1 inhibitors in singlate), 2174 (LYPLA1 inhibitors in singlate), 2177 (LYPLA2 inhibitors in singlate), 2171 (PME-1 inhibitors in triplicate), 2291 (PME-1 inhibitors in singlate), 2233 (LYPLA1 inhibitors in triplicate), 2232 (LYPLA2 inhibitors in triplicate)] | Homo sapiens | 6 | ALA1201862 | assay format | PubChem BioAssays | |
| 2. | ALA1738086 | F | PUBCHEM_BIOASSAY: Late stage assay provider results from the probe development effort to identify inhibitors of protein phosphatase methylesterase 1 (PME-1): Gel-based Activity-Based Protein Profiling (ABPP) IC50 Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2130, AID2143, AID2171, AID2174, AID2177, AID2232, AID2233, AID2291, AID2363, AID2365, AID2366, AID2368, AID2369, AID2371, AID463090, AID463091] | Homo sapiens | 1 | ALA1201862 | assay format | PubChem BioAssays | |
| 3. | ALA1738307 | F | PUBCHEM_BIOASSAY: Late stage assay provider results from the probe development effort to identify inhibitors of protein phosphatase methylesterase 1 (PME-1): Gel-based Activity-Based Protein Profiling (ABPP) IC50 Set 1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2130, AID2143, AID2171, AID2174, AID2177, AID2232, AID2233, AID2291, AID2363, AID2365, AID2366, AID2368, AID2369, AID2371, AID463090, AID463091] | Homo sapiens | 3 | ALA1201862 | assay format | PubChem BioAssays | |
| 4. | ALA1738413 | U | PUBCHEM_BIOASSAY: Late stage results from the probe development effort to identify inhibitors of the protein methylesterase PME-1: Gel-based Activity-Based Protein Profiling (ABPP) IC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2130, AID2143, AID2171, AID2174, AID2177, AID2232, AID2233, AID2291, AID463090, AID463091, AID463124, AID463130, AID463131, AID463132, AID463146, AID463149] Panel member name: PME-1 Assay Panel member description: Inhibition of endogenously expressed PME-1 | 26 | ALA1201862 | assay format | PubChem BioAssays | ||
| 5. | ALA2209035 | B | Inhibition of PME1 expressed in untransfected HEK293T cells assessed as reduction in demethylated PP2A level at 500 nM after 1 hr by Western blot analysis | Homo sapiens | 1 | ALA2203175 | cell-based format | Scientific Literature | |
| 6. | ALA2209036 | B | Inhibition of PME1 expressed in untransfected HEK293T cells assessed as reduction in demethylated PP2A level at 20 uM after 1 hr by Western blot analysis | Homo sapiens | 1 | ALA2203175 | cell-based format | Scientific Literature | |
| 7. | ALA2209037 | B | Inhibition of PME1 overexpressed in HEK293T cells assessed as increase in methylated PP2A level at 20 uM after 1 hr by Western blot analysis | Homo sapiens | 2 | ALA2203175 | cell-based format | Scientific Literature | |
| 8. | ALA2209038 | B | Inhibition of PME1 overexpressed in HEK293T cells assessed as reduction in demethylated PP2A level at 20 uM after 1 hr by Western blot analysis relative to control | Homo sapiens | 2 | ALA2203175 | cell-based format | Scientific Literature | |
| 9. | ALA2209151 | B | Inhibition of PME1 binding to FP-biotin in [12C][14N]-lysine, arginine and [13C6][15N2]-lysine, arginine labeled HEK293T cells at 20 uM after 1 hr by isotopic activity-based protein profiling-MudPIT assay | Homo sapiens | 1 | ALA2203175 | cell-based format | Scientific Literature | |
| 10. | ALA2209152 | B | Inhibition of PME1 binding to FP-rhodamine in HEK293T cells after 1 hr by fluorescence polarization activity-based protein profiling assay | Homo sapiens | 1 | ALA2203175 | cell-based format | Scientific Literature | |
| 11. | ALA2212394 | B | Binding affinity to PME1 assessed as compound-enzyme serine nuclephile adduct formation by MS analysis | 1 | ALA2203175 | single protein format | Scientific Literature | ||
| 12. | ALA2212395 | B | Irreversible inhibition of PME1 binding to FP-rhodamine in human HEK293T cells at 50 uM after 30 mins by gel filtration chromatographic analysis | Homo sapiens | 1 | ALA2203175 | cell-based format | Scientific Literature | |
| 13. | ALA2212397 | B | Inhibition of PME1 binding to FP-rhodamine in human HEK293T cells after 45 mins by fluorescence polarization activity-based protein profiling assay | Homo sapiens | 1 | ALA2203175 | cell-based format | Scientific Literature | |
| 14. | ALA2212401 | B | Inhibition of PME1-based PP2A deethylation in human HEK293T cells at 50 uM after 3 hrs by Western blot analysis | Homo sapiens | 1 | ALA2203175 | cell-based format | Scientific Literature | |
| 15. | ALA2212403 | B | Inhibition of PME1 binding to FP-rhodamine in human MDA-MB-231 cells after 30 mins by fluorescence polarization activity-based protein profiling assay | Homo sapiens | 2 | ALA2203175 | cell-based format | Scientific Literature | |
| 16. | ALA3830914 | B | Inhibition of FP-Rh probe binding to PME-1 (unknown origin) at 100 uM incubated for 30 mins followed by FP-Rh probe addition measured after 30 mins by ABPP gel-based assay | Homo sapiens | 1 | ALA3826942 | single protein format | Scientific Literature | |
| 17. | ALA3830918 | B | Inhibition of FP-Rh probe binding to PME-1 (unknown origin) at 685 nM incubated for 30 mins followed by FP-Rh probe addition measured after 30 mins by ABPP gel-based assay | Homo sapiens | 1 | ALA3826942 | single protein format | Scientific Literature |
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