| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4381025 | B | Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells interaction with Cy5-p22phox149-162 incubated for 10 mins by fluorescence polarization competition assay | Homo sapiens | 74 | cell-based format | Scientific Literature | ||
| 2. | ALA4381026 | B | Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells interaction with Cy5-p22phox149-162 incubated for 10 mins in presence of TCEP by fluorescence polarization competition assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4381027 | B | Ratio of Ki for recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells in presence of TCEP to Ki for recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells by fluorescence polarization competition assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4381028 | B | Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells interaction with Cy5-p22phox149-162 incubated for 2 hrs by fluorescence polarization competition assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4381029 | B | Binding affinity to recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in melting temperature at 0.25 mM incubated for 10 to 15 mins by SYPRO orange dye based thermal shift assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 6. | ALA4381030 | B | Binding affinity to recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in melting temperature at 0.5 mM incubated for 10 to 15 mins by SYPRO orange dye based thermal shift assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 7. | ALA4381031 | B | Binding affinity to recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in melting temperature at 1 mM incubated for 10 to 15 mins by SYPRO orange dye based thermal shift assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 8. | ALA4381032 | B | Binding affinity to recombinant human His-tagged p47phox SH3-AB domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in melting temperature at 2 mM incubated for 10 to 15 mins by SYPRO orange dye based thermal shift assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 9. | ALA4381033 | B | Binding affinity to immobilized recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by SPR assay | Homo sapiens | 37 | cell-based format | Scientific Literature | ||
| 10. | ALA4381034 | B | Binding affinity to immobilized recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as maximal response by SPR assay relative to quinolin-2-amine | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
| 11. | ALA4381035 | B | Binding affinity to immobilized recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as maximal response by SPR assay relative to 2-methyl-4-piperazin-1-yl-quinoline | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 12. | ALA4381037 | B | Inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells interaction with Cy5-p22phox149-162 in presence of TritonX-100 by fluorescence polarization competition assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 13. | ALA4381038 | B | Non-reversible binding affinity to immobilized recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as slow dissociation rate at 12.5 uM by SPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4381039 | B | Binding affinity to immobilized recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells at 12.5 uM in presence of TCEP by SPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4381040 | B | Binding affinity to recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as increase in protein molecular weight at 200 uM by ESI/LC-MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4381041 | B | Binding affinity to recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as protein aggregation by measuring increase in maximum dimensions of the particles by SAXS study analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4381042 | B | Binding affinity to recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as protein aggregation by measuring increase in SAXS-derived radius of gyration by SAXS study analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4381043 | B | Binding affinity to recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as protein aggregation by measuring increase in concentration-normalized scattering intensity by SAXS study analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4381044 | B | Binding affinity to recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as protein aggregation by SAXS study analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4381045 | B | Binding affinity to recombinant human His-tagged 15N-labeled p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as compound interaction with protein at Cys196 in SH3A domain by NMR spectroscopy | Homo sapiens | 1 | cell-based format | Scientific Literature |
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