# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1764243 | Functional | Agonist activity at 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as stimulation intracellular calcium level at 10 nM followed by vehicle addition in presence of digitonin added at 3.5 mins | Homo sapiens | 1 | ALA1759920 | cell-based format | Scientific Literature | |
2. | ALA1764244 | Functional | Agonist activity at 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as stimulation intracellular calcium level at 100 nM followed by 5-oxo-ETE addition at 2.5 mins in presence of digitonin added at 3.5 mins | Homo sapiens | 1 | ALA1759920 | cell-based format | Scientific Literature | |
3. | ALA1764428 | Functional | Desensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization | Homo sapiens | 2 | ALA1759920 | assay format | Scientific Literature | |
4. | ALA3366297 | Functional | Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay | Homo sapiens | 4 | ALA3352521 | assay format | Scientific Literature | |
5. | ALA3373786 | Functional | Antagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometry | Homo sapiens | 3 | ALA3351367 | single protein format | Scientific Literature | |
6. | ALA1686896 | Functional | Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization at 100 nM in presence of 5-oxo-ETE | Homo sapiens | 1 | ALA1681722 | assay format | Scientific Literature | |
7. | ALA1686897 | Functional | Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization | Homo sapiens | 2 | ALA1681722 | assay format | Scientific Literature | |
8. | ALA2339755 | Functional | Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured at 1 uM after 1 min by spectrofluorimetric analysis | Homo sapiens | 1 | ALA2331351 | single protein format | Scientific Literature | |
9. | ALA2339756 | Functional | Antagonist activity at OXE receptor in human neutrophils assessed as LTB4-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis | Homo sapiens | 1 | ALA2331351 | single protein format | Scientific Literature | |
10. | ALA2339757 | Functional | Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured at 30 uM after 1 min by spectrofluorimetric analysis | Homo sapiens | 1 | ALA2331351 | single protein format | Scientific Literature | |
11. | ALA2339758 | Functional | Antagonist activity at OXE receptor in human neutrophils assessed as induction of Ca2+ mobilization at 30 uM after 2 mins by spectrofluorimetric analysis | Homo sapiens | 1 | ALA2331351 | single protein format | Scientific Literature | |
12. | ALA2339759 | Functional | Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis | Homo sapiens | 11 | ALA2331351 | single protein format | Scientific Literature | |
13. | ALA2339760 | Functional | Agonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis | Homo sapiens | 4 | ALA2331351 | single protein format | Scientific Literature | |
14. | ALA3117757 | Functional | Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis | Homo sapiens | 4 | ALA3112579 | assay format | Scientific Literature | |
15. | ALA3117762 | Binding | Antagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysis | Homo sapiens | 2 | ALA3112579 | assay format | Scientific Literature | |
16. | ALA3117763 | Binding | Potency index, ratio of compound activity to Gue1654 activity for antagonism of OXE receptor (unknown origin) expressed in anti-CD49d-labeled neutrophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization | Homo sapiens | 2 | ALA3112579 | assay format | Scientific Literature | |
17. | ALA3117764 | Binding | Potency index, ratio of compound activity to Gue1654 activity for antagonism of OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization | Homo sapiens | 2 | ALA3112579 | assay format | Scientific Literature | |
18. | ALA3117765 | Binding | Antagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled neutrophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysis | Homo sapiens | 2 | ALA3112579 | assay format | Scientific Literature | |
19. | ALA3117953 | Binding | Antagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysis | Homo sapiens | 2 | ALA3112579 | assay format | Scientific Literature | |
20. | ALA3118914 | Functional | Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysis | Homo sapiens | 2 | ALA3112579 | assay format | Scientific Literature |