| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2034650 | F | Agonist activity at RXFP3 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 6 hrs by beta galactosidase reporter gene assay | 3 | ALA2029320 | cell-based format | Scientific Literature | ||
| 2. | ALA2034745 | B | Displacement of europium-labelled H3 relaxin-B chain/INSL-5 chain from RXFP3 expressed in CHO-K1 cells | 12 | ALA2029320 | cell-based format | Scientific Literature | ||
| 3. | ALA3088909 | B | Antagonist activity at RXFP3 (unknown origin) at 10 uM after 3 to 5 hrs by beta-arrestin assay relative to control | Homo sapiens | 1 | ALA3085628 | single protein format | Scientific Literature | |
| 4. | ALA3089340 | B | Agonist activity at RXFP3 (unknown origin) at 10 uM after 90 to 180 mins by beta-arrestin assay relative to control | Homo sapiens | 1 | ALA3085628 | single protein format | Scientific Literature | |
| 5. | ALA4402085 | F | Agonist activity at human RXFP3 expressed in CHOK1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation preincubated for 30 mins followed by forskolin-stimulation and measured after 30 mins by HTRF assay | Homo sapiens | 4 | ALA4400563 | cell-based format | Scientific Literature | |
| 6. | ALA4402086 | F | Agonist activity at human RXFP3 expressed in CHOK1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation preincubated for 30 mins followed by forskolin-stimulation and measured after 30 mins by HTRF assay relative to relaxin-3 | Homo sapiens | 4 | ALA4400563 | cell-based format | Scientific Literature | |
| 7. | ALA4402087 | B | Displacement of [125I]-R3/I5 from human RXFP3 expressed in CHOK1 cell membranes by radioligand binding assay | Homo sapiens | 1 | ALA4400563 | cell-based format | Scientific Literature | |
| 8. | ALA4402090 | F | Agonist activity at human RXFP3 expressed in CHOK1 cell membranes assessed as stimulation of [35S]-GTPgammaS binding after 3 hrs by scintillation counting method | Homo sapiens | 1 | ALA4400563 | cell-based format | Scientific Literature | |
| 9. | ALA4402093 | B | Agonist activity at human RXFP3 expressed in CHOK1 cells assessed as induction of ERK1/2 phosphorylation at 5 uM by Western blot analysis | Homo sapiens | 1 | ALA4400563 | cell-based format | Scientific Literature | |
| 10. | ALA4402094 | B | Agonist activity at human RXFP3 expressed in CHOK1 cells assessed as induction of JNK phosphorylation at 5 uM by Western blot analysis | Homo sapiens | 1 | ALA4400563 | cell-based format | Scientific Literature | |
| 11. | ALA4402095 | B | Agonist activity at human RXFP3 expressed in CHOK1 cells assessed as induction of p38 MAPK phosphorylation at 5 uM by Western blot analysis | Homo sapiens | 1 | ALA4400563 | cell-based format | Scientific Literature | |
| 12. | ALA4432200 | B | Displacement of Eu-H3/15 from human RXFP3 receptor expressed in CHOK1 cells by time-resolved fluorescent whole cell binding assay | Homo sapiens | 10 | ALA4431328 | cell-based format | Scientific Literature | |
| 13. | ALA4432201 | F | Agonist activity at human RXFP3 receptor expressed in CHOK1 cells cotransfected with beta-galactosidase assessed as inhibition of forskolin-stimulated cAMP by beta-galactosidase reporter gene assay | Homo sapiens | 14 | ALA4431328 | cell-based format | Scientific Literature | |
| 14. | ALA4432206 | B | Agonist activity at human RXFP3 receptor expressed in CHOK1 cells assessed as ERK1/2 phosphorylation incubated for 5 mins by alphascreen surefire assay | Homo sapiens | 1 | ALA4431328 | cell-based format | Scientific Literature | |
| 15. | ALA4731844 | B | Displacement of Eu-labeled H3B1-22R from RXFP3 (unknown origin) stably expressed in CHO-K1 cells by competition binding assay | Homo sapiens | 5 | ALA4725486 | cell-based format | Scientific Literature | |
| 16. | ALA4731845 | F | Agonist activity at RXFP3 (unknown origin) stably expressed in CHO-K1 cells co-transfected with pCRE assessed as inhibition of forskolin-induced cAMP accumulation measured after 6 hrs by beta-galactosidase reporter gene assay | Homo sapiens | 5 | ALA4725486 | cell-based format | Scientific Literature | |
| 17. | ALA4883590 | B | PRESTO-Tango GPCRome screening (RXFP3) | 1 | ALA4507309 | single protein format | Donated Chemical Probes - SGC Frankfurt | ||
| 18. | ALA5033950 | F | Agonist activity at human RXFP3 expressed in human CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 1.5 hrs by TR-FRET assay | Homo sapiens | 56 | ALA5032539 | cell-based format | Scientific Literature | |
| 19. | ALA5033951 | F | Agonist activity at human RXFP3 expressed in human CHO-K1 cells assessed as maximal inhibition of forskolin-induced cAMP accumulation measured after 1.5 hrs by TR-FRET assay relative to relaxin 3 | Homo sapiens | 56 | ALA5032539 | cell-based format | Scientific Literature | |
| 20. | ALA5033952 | F | Agonist activity at human RXFP3 expressed in human CHO-K1 cells assessed as beta arrestin-2 recruitment measured after 4 hrs by beta-galactosidase based beta arrestin2 recruitment assay | Homo sapiens | 4 | ALA5032539 | cell-based format | Scientific Literature |
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