# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1794368 | Functional | PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159] | 19 | ALA1201862 | assay format | PubChem BioAssays | ||
2. | ALA3386599 | Functional | Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assay | Homo sapiens | 27 | ALA3352267 | cell-based format | Scientific Literature | |
3. | ALA3386600 | Functional | Agonist activity at human APJ receptor expressed in Chem-5 cells assessed as calcium mobilization by FLIPR assay | Homo sapiens | 1 | ALA3352267 | cell-based format | Scientific Literature | |
4. | ALA3386603 | Functional | Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assay relative to [pyr1]-apelin-13 | Homo sapiens | 7 | ALA3352267 | cell-based format | Scientific Literature | |
5. | ALA3242425 | Binding | Displacement of [125I]-pE13F from human apelin receptor expressed in CHO cell membranes after 1 hr by gamma counting analysis | Homo sapiens | 20 | ALA3232849 | cell-based format | Scientific Literature | |
6. | ALA3266750 | Functional | Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization | Homo sapiens | 33 | ALA3259718 | cell-based format | Scientific Literature | |
7. | ALA3266751 | Functional | Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization relative to pyr-apelin-13 | Homo sapiens | 23 | ALA3259718 | cell-based format | Scientific Literature | |
8. | ALA4371614 | Binding | Agonist activity at human APJ receptor by saphenous vein contraction assay | Homo sapiens | 2 | ALA4371007 | assay format | Scientific Literature | |
9. | ALA4371615 | Binding | Agonist activity at human APJ receptor assessed as increase in beta-arrestin recruitment | Homo sapiens | 2 | ALA4371007 | single protein format | Scientific Literature | |
10. | ALA4371616 | Binding | Induction of human APJ receptor internalization by cell based assay | Homo sapiens | 2 | ALA4371007 | cell-based format | Scientific Literature | |
11. | ALA4371617 | Binding | Agonist activity at human APJ receptor assessed as increase in beta-arrestin1 recruitment | Homo sapiens | 1 | ALA4371007 | single protein format | Scientific Literature | |
12. | ALA4371618 | Binding | Agonist activity at human APJ receptor assessed as increase in beta-arrestin2 recruitment | Homo sapiens | 1 | ALA4371007 | single protein format | Scientific Literature | |
13. | ALA4371619 | Binding | Agonist activity at human APJ receptor assessed as Gi activation | Homo sapiens | 1 | ALA4371007 | single protein format | Scientific Literature | |
14. | ALA4371620 | Binding | Agonist activity at human APJ receptor assessed as Go activation | Homo sapiens | 1 | ALA4371007 | single protein format | Scientific Literature | |
15. | ALA4371621 | Binding | Agonist activity at GFP10 tagged human APJ receptor expressed in HEK293 cells harboring Rluc2-beta-arrestin1 assessed as increase in beta-arrestin1 recruitment after 30 mins by BRET-based luciferase reporter gene assay | Homo sapiens | 1 | ALA4371007 | cell-based format | Scientific Literature | |
16. | ALA4371622 | Binding | Agonist activity at human APJ receptor expressed in HEK293 cells harboring Rluc2-beta-arrestin2 assessed as increase in beta-arrestin2 recruitment after 30 mins by BRET-based luciferase reporter gene assay | Homo sapiens | 1 | ALA4371007 | cell-based format | Scientific Literature | |
17. | ALA4371623 | Binding | Agonist activity at GFP10 tagged human APJ receptor expressed in HEK293 cells harboring Rluc2-Galphai1/GFP10-Ggamma/Gbeta1 after 5 mins by BRET assay | Homo sapiens | 1 | ALA4371007 | cell-based format | Scientific Literature | |
18. | ALA4371624 | Binding | Agonist activity at GFP10 tagged human APJ receptor expressed in HEK293 cells harboring Rluc2-Galpha0A/GFP10-Ggamma/Gbeta1 after 5 mins by BRET assay | Homo sapiens | 1 | ALA4371007 | cell-based format | Scientific Literature | |
19. | ALA4371625 | Functional | Agonist activity at APJ receptor (unknown origin) assessed as inhibition of forskolin-induced cAMP accumulation | Homo sapiens | 1 | ALA4371007 | assay format | Scientific Literature | |
20. | ALA4371626 | Binding | Agonist activity at APJ receptor (unknown origin) assessed as increase in beta-arrestin recruitment | Homo sapiens | 1 | ALA4371007 | single protein format | Scientific Literature |